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Gene · 53905

DUOX1: dual oxidase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DUOX1: dual oxidase 1. Genes, record 53905. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/53905

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Gene

Symbol
DUOX1
HGNC
Name
dual oxidase 1
HGNC
NCBI Gene ID
53905
NCBI Gene
HGNC ID
HGNC:3062
HGNC
Ensembl
ENSG00000137857
NCBI Gene
Aliases
LNOX1, NOXEF1, THOX1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NRD9Dual oxidase 11,5512Ensembl, GeneID, HGNC

Source UniProt

Patents63

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1444301Q9NRD9Espacenet
JP 2026004568 A2026-01-1444302Q9NRD9Espacenet
JP 2026004568 A2026-01-1444303Q9NRD9Espacenet
EP 4650780 A22025-11-195149Q9NRD9Espacenet
EP 4641201 A22025-10-294746Q9NRD9Espacenet
JP 2025147176 A2025-10-064470Q9NRD9Espacenet
JP 2025147176 A2025-10-064471Q9NRD9Espacenet
JP 2025529142 A2025-09-041335Q9NRD9Espacenet
JP 2025529142 A2025-09-046214Q9NRD9Espacenet
US 12371689 B22025-07-291335Q9NRD9Espacenet

1 to 10 of 63

See all 63 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,077

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDUOX1 papersNewest fiscal year
ZIABC010677NADPH Oxidases as Novel Targets for Cancer Therapy112025
P30ES005605Environmental Health Sciences Research Center82025
P30CA016672Cancer Center Support Grant62025
R01DK015070Thyroid Physiology Studies of Inherited Disorders62025
P30CA008748Cancer Center Support Grant42025
P30DK054759Precision Medicine Center for Cystic Fibrosis42025
P50AA011999Southern California Research Center for ALPD and Cirrhosis42025
P30DK020595Diabetes Research and Training Center32025
P51OD011104Tulane National Primate Research Center32025
P20GM103449Vermont Biomedical Research Network-Vermont INBRE22025

1 to 10 of 1,077Source NIH's project files

See all 1,077 nih grants

Papers1,614

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Thyroid hormone synthesis and AITD-related inflammatory factors are modulated during early pregnancy in ewes.Theriogenology202742790002PubTator, text miningPubMed
"NADPH Oxidases: Central Regulators of Redox Signalling and Cellular Homeostasis".Curr Diabetes Rev202642695285PubTator, text miningPubMed
Disulfidptosis- and Ferroptosis-Related Gene Signatures in Rheumatoid Arthritis: Association Analysis and Diagnostic Model Construction.Kaohsiung J Med Sci202642690169PubTator, text miningPubMed
A hybrid machine learning framework with two-step feature selection for identifying key biomarkers and drug targets in monkeypox.Biochem Biophys Rep202642434339PubTator, text miningPubMed
Human-relevant exposure to mixtures of rare earth elements disrupts T3 homeostasis through impaired synthesis and conversion in human Thyrocytes.Toxicol Appl Pharmacol202642364782PubTator, text miningPubMed
From Defense to Disease: NADPH Oxidase in Cellular Function and Dysregulation.J Immunol Res202642360039PubTator, text miningPubMed
Structural bioinformatic studies of eight integral transmembrane NADPH oxidases and their AlphaFold 3 predicted QTY analogs with reduced hydrophobicity.PLoS One202642268815PubTator, text miningPubMed
S100A8-associated inflammatory microenvironment is related to its cell-of-origin and potentiates BRAF inhibitor resistance in papillary craniopharyngioma.Clin Exp Med202641920205PubTator, text miningPubMed
Corrigendum to: DUOX1 inhibits the progression of rheumatoid arthritis by regulating the NF-κB pathway in vitro.Allergol Immunopathol (Madr)202641910349PubTator, text miningPubMed
Genetic parameter estimation and genome-wide association study of fiber characteristics for cashmere goats in the United States.J Anim Sci202641830137PubTator, text miningPubMed

1 to 10 of 1,614

See all 1,614 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/53905

GET https://conductscience.org/api/genes/v1/53905/patents?page=2