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Gene · 5394

EXOSC10: exosome component 10

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. EXOSC10: exosome component 10. Genes, record 5394. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5394

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Gene

Symbol
EXOSC10
HGNC
Name
exosome component 10
HGNC
NCBI Gene ID
5394
NCBI Gene
HGNC ID
HGNC:9138
HGNC
Ensembl
ENSG00000171824
NCBI Gene
Aliases
PM-Scl, PM/Scl-100, PMSCL, PMSCL2, RRP6, Rrp6p, p2, p3, p4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q01780Exosome complex component 108857Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12560619 B22026-02-2483Q01780Espacenet
JP 2026004568 A2026-01-1445638Q01780Espacenet
EP 4650780 A22025-11-199855Q01780Espacenet
EP 4641201 A22025-10-2910104Q01780Espacenet
JP 2025517969 A2025-06-1210104Q01780Espacenet
JP 2025517970 A2025-06-129855Q01780Espacenet
US 12038446 B22024-07-1683Q01780Espacenet
US 11446398 B22022-09-2029144Q01780Espacenet
JP 2022538760 A2022-09-0616Q01780Espacenet
JP 2022524081 A2022-04-27132115Q01780Espacenet

1 to 10 of 26

See all 26 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants719

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEXOSC10 papersNewest fiscal year
ZIAES101074Environmental/genetic Risk Factors and Pathogenesis of Autoimmune Disease162025
P30AR070254Johns Hopkins Rheumatic Diseases Resource-based Core Center (Johns Hopkins RDRCC)142025
P30CA008748Cancer Center Support Grant142025
R35GM118080Structural studies of RNA processing and ubiquitin-like protein modification102025
ZIAAR041203Muscle Disease Unit92025
R01AI099195Role of ncRNA Surveillance Complex "RNA Exosome" in Class Switch Recombination and Somatic Hypermutation72025
T32AR048522Multidisciplinary Rheumatology Training Program72025
R01AR073208Autoantibodies define scleroderma subgroups with distinct relationships to cancer62025
T32HL007605Research training in respiratory biology42025
ZIAES101081Assessment, Therapy and Prevention Of Autoimmune Disease42025

1 to 10 of 719Source NIH's project files

See all 719 nih grants

Papers1,573

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Autoantibody Profiles and Clinical Correlations in Systemic Sclerosis: A Cross-Sectional Study.EJIFCC202642699467PubTator, text miningPubMed
DNTTIP2 coordinates RNA exosome activities to ensure fidelity of human ribosome assembly.Nat Commun202642693119PubTator, text miningPubMed
Polymyositis with scleroderma-like features and an anti-PM-Scl75 antibody detected by line blot but not by protein array or immunoprecipitation: A case report and literature review.Mod Rheumatol Case Rep202642644748PubTator, text miningPubMed
RNA decay rate as a control point for long non-coding RNA function: a BRIC-based causal analysis of NEAT1.Gene202642628853PubTator, text miningPubMed
Case Report: Eosinophilic fasciitis with PM-Scl antibody positivity: expanding the serological spectrum.Front Med (Lausanne)202642577884PubTator, text miningPubMed
Inaugural complete heart block in anti-SSA negative systemic lupus erythematosus: the diagnostic role of anti-PM-Scl 100 antibodies.Lupus202642522210PubTator, text miningPubMed
ATRX loss in sarcomas is associated with dysregulated gene and transposable element expression, loss of DNA methylation, and worse survival.ESMO Rare Cancers202641994103PubTator, text miningPubMed
Clinical relevance of specific and non-specific autoantibodies in systemic sclerosis without overlap features.Semin Arthritis Rheum202641990462PubTator, text miningPubMed
Evaluation of Anti-dsDNA Antibodies in Laboratory Practice: Management of Different Analytical Methods and Correlation with HEp-2 Immunofluorescence Patterns.Antibodies (Basel)202641874028PubTator, text miningPubMed
The Myositis Overlap Conundrum: Differentiating Polymyositis from Inclusion Body Myositis.Juntendo Med J202641859227PubTator, text miningPubMed

1 to 10 of 1,573

See all 1,573 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5394

GET https://conductscience.org/api/genes/v1/5394/patents?page=2