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PMS2: PMS1 homolog 2, mismatch repair system component

1 protein, 34 patents, 0 drugs, 0 trials, 3,016 NIH grants and 10,279 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPMS2HGNC
NamePMS1 homolog 2, mismatch repair system componentHGNC
NCBI Gene ID5395NCBI Gene
HGNC IDHGNC:9122HGNC
EnsemblENSG00000122512NCBI Gene
AliasesHNPCC4, H_DJ0042M02.9, LYNCH4, MLH4, MMRCS4, PMS-2, PMSL2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P54278Mismatch repair endonuclease PMS28629Ensembl, GeneID, HGNCUniProt

Patents 34

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-292120P54278Espacenet
JP 2025517969 A2025-06-122120P54278Espacenet
EP 4464338 A22024-11-20355P54278Espacenet
JP 2024123008 A2024-09-107738P54278Espacenet
US 11976334 B22024-05-07181P54278Espacenet
JP 2023098973 A2023-07-1111P54278Espacenet
US 11680268 B22023-06-20355P54278Espacenet
KR 1020220138789 A2022-10-132P54278Espacenet
US 11446398 B22022-09-2064373P54278Espacenet
JP 2022524081 A2022-04-27167344P54278Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 3016

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant2072,025NIH's project files
P30CA016672Cancer Center Support Grant1232,025NIH's project files
P30CA016058Cancer Center Support Grant732,025NIH's project files
P30CA015704Cancer Center Support Grant432,025NIH's project files
P30CA006973Regional Oncology Research Center412,025NIH's project files
U01CA167551Colon Cancer Family Registry Cohort382,025NIH's project files
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant312,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award302,025NIH's project files
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)222,025NIH's project files
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028182,025NIH's project files

Papers 10279

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42822083PubTator, text miningPubMed
42821536PubTator, text miningPubMed
42814501PubTator, text miningPubMed
42809083PubTator, text miningPubMed
42802819PubTator, text miningPubMed
42801369PubTator, text miningPubMed
42798309PubTator, text miningPubMed
42794913PubTator, text miningPubMed
42788712PubTator, text miningPubMed
42757994PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license