Gene · 5396
PRRX1: paired related homeobox 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PRRX1: paired related homeobox 1. Genes, record 5396. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5396
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P54821 | Paired mesoderm homeobox protein 1 | 245 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents26
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 56914 | P54821 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 999 | P54821 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 15541 | P54821 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 999 | P54821 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 34159 | P54821 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 15541 | P54821 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 15541 | P54821 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 34159 | P54821 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 15380 | P54821 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 34159 | P54821 | Espacenet |
1 to 10 of 26
See all 26 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,372
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PRRX1 papers | Newest fiscal year |
|---|---|---|---|
| R01HL092577 | IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL | 13 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 9 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 8 | 2025 |
| P30AR069619 | Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application) | 5 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| R01HL086694 | From GWAS loci to blood pressure genes, variants & mechanisms - Renewal | 5 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 4 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 4 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 4 | 2025 |
| P30DK050306 | Center for Molecular Studies in Digestive and Liver Diseases | 4 | 2025 |
1 to 10 of 1,372Source NIH's project files
See all 1,372 nih grantsPapers1,667
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Stromal Hedgehog Signaling Drives Segment-Specific Malignant Transformation of Gastrointestinal Stem Cells by Producing Bone Morphogenetic Protein Antagonists. | Cell Mol Gastroenterol Hepatol | 2026 | 42556639 | PubTator, text mining | PubMed |
| Distinct transcriptomic features of tumor and stromal cells in direct contact in luminal and triple-negative breast cancers. | Explor Target Antitumor Ther | 2026 | 42539924 | PubTator, text mining | PubMed |
| Correction: PRRX1 upregulates PD-L1 in human mesenchymal stem cells. | In Vitro Cell Dev Biol Anim | 2026 | 42509405 | PubTator, text mining | PubMed |
| Multi-omics analysis of the rhizosphere effects and molecular mechanisms of Ageratum conyzoides linn. at different stages of Cd, Pb, and Zn co-stress. | J Environ Manage | 2026 | 42485963 | PubTator, text mining | PubMed |
| Developmental stage-dependent cellular plasticity governs β-cell reprogramming efficiency in human fibroblasts. | Biochem Biophys Res Commun | 2026 | 42335655 | PubTator, text mining | PubMed |
| A Primary Open-Angle Glaucoma Locus Near Transcription Factor PRRX1 Identified in the Million Veteran Program. | Ophthalmol Sci | 2026 | 42256007 | PubTator, text mining | PubMed |
| Multimodal atlas of human atherosclerosis links granular vascular cell states to coronary artery disease risk. | medRxiv | 2026 | 42245058 | PubTator, text mining | PubMed |
| Dermal-Based Spindle Cell Lipoma: A Case Series of 12 Patients. | J Cutan Pathol | 2026 | 42170729 | PubTator, text mining | PubMed |
| Small Extracellular Vesicles-Derived Circ6718 Unlocks Stromal Remodeling and Serves as a Biomarker in Gastric Cancer. | Adv Sci (Weinh) | 2026 | 42114147 | PubTator, text mining | PubMed |
| Inhibition of Dot1L Histone Methyltransferase Expands Bone Injury-Responsive CXCL12+ Stromal Progenitors. | bioRxiv | 2026 | 41993436 | PubTator, text mining | PubMed |
1 to 10 of 1,667
See all 1,667 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5396
GET https://conductscience.org/api/genes/v1/5396/patents?page=2