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Gene · 5396

PRRX1: paired related homeobox 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PRRX1: paired related homeobox 1. Genes, record 5396. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5396

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Gene

Symbol
PRRX1
HGNC
Name
paired related homeobox 1
HGNC
NCBI Gene ID
5396
NCBI Gene
HGNC ID
HGNC:9142
HGNC
Ensembl
ENSG00000116132
NCBI Gene
Aliases
AGOTC, PHOX1, PMX1, PRX-1, PRX1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P54821Paired mesoderm homeobox protein 12450Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1456914P54821Espacenet
EP 4650780 A22025-11-19999P54821Espacenet
JP 2025147176 A2025-10-0615541P54821Espacenet
JP 2025517970 A2025-06-12999P54821Espacenet
JP 2025032204 A2025-03-1134159P54821Espacenet
JP 2025028160 A2025-02-2815541P54821Espacenet
KR 1020250010750 A2025-01-2115541P54821Espacenet
EP 4461818 A22024-11-1334159P54821Espacenet
JP 2024109657 A2024-08-1415380P54821Espacenet
JP 2023058610 A2023-04-2534159P54821Espacenet

1 to 10 of 26

See all 26 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,372

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePRRX1 papersNewest fiscal year
R01HL092577IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL132025
P30CA008748Cancer Center Support Grant92025
P30DK063491Diabetes Research Center (DRC)82025
P30AR069619Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application)52025
P30CA016672Cancer Center Support Grant52025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal52025
P30CA010815Consolidated Basic Cancer Research Program42025
P30CA016056Roswell Park Cancer Center Support Grant42025
P30CA021765Cancer Center Support Grant (CCSG)42025
P30DK050306Center for Molecular Studies in Digestive and Liver Diseases42025

1 to 10 of 1,372Source NIH's project files

See all 1,372 nih grants

Papers1,667

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Stromal Hedgehog Signaling Drives Segment-Specific Malignant Transformation of Gastrointestinal Stem Cells by Producing Bone Morphogenetic Protein Antagonists.Cell Mol Gastroenterol Hepatol202642556639PubTator, text miningPubMed
Distinct transcriptomic features of tumor and stromal cells in direct contact in luminal and triple-negative breast cancers.Explor Target Antitumor Ther202642539924PubTator, text miningPubMed
Correction: PRRX1 upregulates PD-L1 in human mesenchymal stem cells.In Vitro Cell Dev Biol Anim202642509405PubTator, text miningPubMed
Multi-omics analysis of the rhizosphere effects and molecular mechanisms of Ageratum conyzoides linn. at different stages of Cd, Pb, and Zn co-stress.J Environ Manage202642485963PubTator, text miningPubMed
Developmental stage-dependent cellular plasticity governs β-cell reprogramming efficiency in human fibroblasts.Biochem Biophys Res Commun202642335655PubTator, text miningPubMed
A Primary Open-Angle Glaucoma Locus Near Transcription Factor PRRX1 Identified in the Million Veteran Program.Ophthalmol Sci202642256007PubTator, text miningPubMed
Multimodal atlas of human atherosclerosis links granular vascular cell states to coronary artery disease risk.medRxiv202642245058PubTator, text miningPubMed
Dermal-Based Spindle Cell Lipoma: A Case Series of 12 Patients.J Cutan Pathol202642170729PubTator, text miningPubMed
Small Extracellular Vesicles-Derived Circ6718 Unlocks Stromal Remodeling and Serves as a Biomarker in Gastric Cancer.Adv Sci (Weinh)202642114147PubTator, text miningPubMed
Inhibition of Dot1L Histone Methyltransferase Expands Bone Injury-Responsive CXCL12+ Stromal Progenitors.bioRxiv202641993436PubTator, text miningPubMed

1 to 10 of 1,667

See all 1,667 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5396

GET https://conductscience.org/api/genes/v1/5396/patents?page=2