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Gene · 540

ATP7B: ATPase copper transporting beta

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ATP7B: ATPase copper transporting beta. Genes, record 540. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/540

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Gene

Symbol
ATP7B
HGNC
Name
ATPase copper transporting beta
HGNC
NCBI Gene ID
540
NCBI Gene
HGNC ID
HGNC:870
HGNC
Ensembl
ENSG00000123191
NCBI Gene
Aliases
PWD, WC1, WD, WND
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P35670Copper-transporting ATPase 21,46513Ensembl, GeneID, HGNC

Source UniProt

Patents77

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4754245 A12026-06-1036P35670Espacenet
JP 2026067851 A2026-04-21133P35670Espacenet
JP 2026509434 A2026-03-1936P35670Espacenet
EP 4677077 A12026-01-1436P35670Espacenet
EP 4650780 A22025-11-191075P35670Espacenet
US 12473567 B22025-11-1883P35670Espacenet
US 12473568 B22025-11-1883P35670Espacenet
JP 2025169942 A2025-11-14857P35670Espacenet
US 12460228 B22025-11-042P35670Espacenet
EP 4641201 A22025-10-29754P35670Espacenet

1 to 10 of 77

See all 77 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,162

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleATP7B papersNewest fiscal year
R01DK071865Molecular Mechanisms of Active Copper Transport372025
R01GM079465Chemical Probes to Study Copper Biology112025
P30CA016672Cancer Center Support Grant102025
P20GM103395Alaska INBRE 5 One Health72025
R35GM118021Genetic and Molecular Dissection of the Neurospora Clock62025
R01DK117396Copper Homeostasis and Liver Function52025
UL1TR001863Yale Clinical and Translational Science Award52025
P30CA013330Cancer Center Support Grant42025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center42025
P30DK026743UCSF Liver Center42025

1 to 10 of 1,162Source NIH's project files

See all 1,162 nih grants

Papers3,770

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A hepatic-targeting NIR fluorescent probe simultaneously unlocked by BChE and high viscosity in diabetes mellitus.Spectrochim Acta A Mol Biomol Spectrosc202742785018PubTator, text miningPubMed
Roles of cuproptosis in central nervous system tumors: from molecular mechanisms to therapeutic prospects.Front Cell Dev Biol202642812787PubTator, text miningPubMed
Disrupted copper homeostasis promotes osteopontin-mediated hepatocyte-stellate cell crosstalk in Wilson disease.Cytokine202642800295PubTator, text miningPubMed
digitalMLPA EZtec-MS: A new highly multiplexed DNA probe-based technique for neonatal screening.Eur J Hum Genet202642773160PubTator, text miningPubMed
Copper homeostasis in macrophages: regulatory mechanisms and immunological implications.Front Chem202642769650PubTator, text miningPubMed
Neutrophil extracellular traps delivering lactylated S100a9 aggravate neuronal cuproptosis by regulating Ttr/Commd1/Atp7b axis after traumatic brain injury.Redox Biol202642767162PubTator, text miningPubMed
SOX2 Inhibits Cuproptosis to Affect Cisplatin Resistance in Non-Small Cell Lung Cancer by Activating the Wnt/ATP7B Signaling Pathway.Kaohsiung J Med Sci202642757550PubTator, text miningPubMed
Utility of High-Throughput Genomic Analysis for Genetic Counseling in Large Family with Wilson Disease Carrying a Novel 28-bp ATP7B Splice-Junction Deletion.Diagnostics (Basel)202642739114PubTator, text miningPubMed
Copper, cuproptosis, and cancer: biology concepts of a novel cell death.Apoptosis202642693224PubTator, text miningPubMed
Diagnostic challenges and mimicking disorders of Wilson's Disease: A comprehensive review.Caspian J Intern Med202642668699PubTator, text miningPubMed

1 to 10 of 3,770

See all 3,770 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/540

GET https://conductscience.org/api/genes/v1/540/patents?page=2