Gene · 5406
PNLIP: pancreatic lipase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PNLIP: pancreatic lipase. Genes, record 5406. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5406
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P16233 | Pancreatic triacylglycerol lipase | 465 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents79
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026094314 A | 2026-06-09 | 45 | P16233 | Espacenet |
| EP 4705273 A2 | 2026-03-11 | 518 | P16233 | Espacenet |
| JP 2026021360 A | 2026-02-10 | 136 | P16233 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 57041 | P16233 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 8591 | P16233 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 8745 | P16233 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 10576 | P16233 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 7390 | P16233 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 7390 | P16233 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 8745 | P16233 | Espacenet |
1 to 10 of 79
See all 79 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials43
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07326839 | ORLISTAT | ClinicalTrials.gov | ||
| NCT06993428 | ORLISTAT | PHASE2 | ClinicalTrials.gov | |
| NCT06818955 | ORLISTAT | PHASE2 | ClinicalTrials.gov | |
| NCT06625736 | ORLISTAT | ClinicalTrials.gov | ||
| NCT06501326 | ORLISTAT | PHASE4 | ClinicalTrials.gov | |
| NCT05934110 | ORLISTAT | PHASE2 | ClinicalTrials.gov | |
| NCT04521751 | ORLISTAT | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT03884127 | ORLISTAT | ClinicalTrials.gov | ||
| NCT03675191 | ORLISTAT | ClinicalTrials.gov | ||
| NCT02767531 | ORLISTAT | PHASE2 | 2019-02-01 | ClinicalTrials.gov |
1 to 10 of 43
See all 43 trialsNIH grants871
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PNLIP papers | Newest fiscal year |
|---|---|---|---|
| U01DK108334 | INSPPIRE: Using the natural history of pediatric chronic pancreatitis to identify disease predictors and design therapies | 6 | 2025 |
| P30CA056036 | Translational Research in Cancer | 4 | 2025 |
| P30DK052574 | Host-environment interactions in the pathophysiology of digestive disease | 3 | 2025 |
| P30DK054759 | Precision Medicine Center for Cystic Fibrosis | 3 | 2025 |
| R01DK128188 | Pathophysiology of Chronic Pancreatitis Associated with Misfolded PNLIP Risk Variants | 3 | 2025 |
| R01HL086694 | From GWAS loci to blood pressure genes, variants & mechanisms - Renewal | 3 | 2025 |
| T32GM008562 | Clinical Pharmacology Training Program | 3 | 2025 |
| U01DK108306 | UPMC Clinical Center for the Study of Chronic Pancreatitis and Diabetes | 3 | 2025 |
| U01DK108314 | Cedars Sinai Center for the Chronic Pancreatitis Clinical Research Consortium | 3 | 2025 |
| P01CA125066 | Discovery of Anticancer Agents of Diverse Natural Origin | 2 | 2025 |
1 to 10 of 871Source NIH's project files
See all 871 nih grantsPapers3,840
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| A machine learning-assisted colorimetric sensor array based on Fe-doped MnO₂/graphene composites for flavonoid identification and bioactivity prediction in vine tea. | Food Chem | 2026 | 42785022 | PubTator, text mining | PubMed |
| Chemical and Enantioselective Characterization and Preliminary Biological Activities of Aristolochia lingulata Aerial-Part Essential Oil. | Plants (Basel) | 2026 | 42739459 | PubTator, text mining | PubMed |
| Lipase ITB 2.1: a structure- and function-validated model for anti-obesity drug screening. | Mol Divers | 2026 | 42732036 | PubTator, text mining | PubMed |
| Bioactive structural features of natural polysaccharides: Inspiration for novel polymer strategies against metabolic disorders. | Carbohydr Res | 2026 | 42715720 | PubTator, text mining | PubMed |
| A Systematic Review and Meta-Analysis of Malnutrition and Metabolic Failure in High-Potency Incretin Therapy. | Obes Sci Pract | 2026 | 42707648 | PubTator, text mining | PubMed |
| Virtual screening of human pancreatic lipase inhibitors using an integrated transfer learning and molecular dynamics simulation. | Bioinformation | 2026 | 42701742 | PubTator, text mining | PubMed |
| [Two new indole alkaloids from Nelumbinis Folium and their hypolipidemic activities]. | Zhongguo Zhong Yao Za Zhi | 2026 | 42693050 | PubTator, text mining | PubMed |
| Antiobesity, antidiabetic, and antioxidant activities of selected Rubia species (Rubiaceae) and LC-MS/MS-based chemical profiling. | Turk J Med Sci | 2026 | 42677271 | PubTator, text mining | PubMed |
| Comparative Characterisation and In Vitro Metabolic Bioactivities of Fucoidan-Rich Extracts from Three South African Brown Macroalgae. | Molecules | 2026 | 42653904 | PubTator, text mining | PubMed |
| Elevated ozone reprograms secondary metabolism in Abelmoschus moschatus pods, enhancing antidiabetic and antiobesity bioactivities. | Plant Cell Rep | 2026 | 42622685 | PubTator, text mining | PubMed |
1 to 10 of 3,840
See all 3,840 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5406
GET https://conductscience.org/api/genes/v1/5406/patents?page=2