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TLR9: toll like receptor 9

1 protein, 109 patents, 11 drugs, 348 trials, 10,038 NIH grants and 22,131 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTLR9HGNC
Nametoll like receptor 9HGNC
NCBI Gene ID54106NCBI Gene
HGNC IDHGNC:15633HGNC
EnsemblENSG00000239732NCBI Gene
AliasesCD289NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q9NR96Toll-like receptor 91,0323Ensembl, GeneID, HGNCUniProt

Patents 109

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1467235Q9NR96Espacenet
JP 2025538131 A2025-11-2694Q9NR96Espacenet
EP 4650780 A22025-11-197810Q9NR96Espacenet
EP 4641201 A22025-10-297897Q9NR96Espacenet
EP 4611777 A12025-09-1094Q9NR96Espacenet
JP 2025529142 A2025-09-044687Q9NR96Espacenet
US 12371689 B22025-07-294687Q9NR96Espacenet
US 12365711 B22025-07-2224Q9NR96Espacenet
KR 1020250099210 A2025-07-0194Q9NR96Espacenet
JP 2025517969 A2025-06-127897Q9NR96Espacenet

Drugs 11

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
1018 ISSCHEMBL4297680Toll-like receptor 9 agonistAGONISTChEMBL
AGATOLIMODCHEMBL2103792Toll-like receptor 9 agonistAGONISTChEMBL
AGATOLIMOD SODIUMCHEMBL2103793Toll-like receptor 9 agonistAGONISTChEMBL
BAZLITORANCHEMBL4297995Toll-like receptor 9 antagonistANTAGONISTChEMBL
COBITOLIMODCHEMBL4297564Toll-like receptor 9 agonistAGONISTChEMBL
EMD-1201081CHEMBL4297993Toll-like receptor 9 agonistAGONISTChEMBL
HYDROXYCHLOROQUINECHEMBL1535Toll-like receptor 9 antagonistANTAGONISTChEMBL
HYDROXYCHLOROQUINE SULFATECHEMBL1690Toll-like receptor 9 antagonistANTAGONISTChEMBL
LEFITOLIMODCHEMBL4297776Toll-like receptor 9 agonistAGONISTChEMBL
TILSOTOLIMODCHEMBL4297838Toll-like receptor 9 agonistAGONISTChEMBL

Trials 348

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07467252HYDROXYCHLOROQUINEPHASE2ClinicalTrials.gov
NCT07443436HYDROXYCHLOROQUINEPHASE2ClinicalTrials.gov
NCT07265297HYDROXYCHLOROQUINEPHASE3ClinicalTrials.gov
NCT07190534HYDROXYCHLOROQUINEClinicalTrials.gov
NCT07061717HYDROXYCHLOROQUINEPHASE3ClinicalTrials.gov
NCT07013110HYDROXYCHLOROQUINEPHASE2ClinicalTrials.gov
NCT06971744HYDROXYCHLOROQUINEPHASE2ClinicalTrials.gov
NCT06949982HYDROXYCHLOROQUINEPHASE2ClinicalTrials.gov
NCT06939582HYDROXYCHLOROQUINE SULFATEPHASE1/PHASE2ClinicalTrials.gov
NCT06816810HYDROXYCHLOROQUINEPHASE2ClinicalTrials.gov

NIH grants 10038

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant512,025NIH's project files
P30CA008748Cancer Center Support Grant412,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award292,025NIH's project files
P30CA033572Cancer Center Support Grant282,025NIH's project files
P30DK034989Yale Liver Center262,025NIH's project files
P30DK034854Integrated Epithelial and Muscosal Biology252,025NIH's project files
P30CA086862Cancer Center Support Grant222,025NIH's project files
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital202,025NIH's project files
R01AI072429Regulation of TLR trafficking for proper self versus non-self discrimination192,025NIH's project files
P30CA014520UW Comprehensive Cancer Center Support182,025NIH's project files

Papers 22131

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42821375PubTator, text miningPubMed
42815330PubTator, text miningPubMed
42815275PubTator, text miningPubMed
42812399PubTator, text miningPubMed
42806308PubTator, text miningPubMed
42794836PubTator, text miningPubMed
42792173PubTator, text miningPubMed
42792149PubTator, text miningPubMed
42790164PubTator, text miningPubMed
42789389PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license