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Gene · 54107

POLE3: DNA polymerase epsilon 3, accessory subunit

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. POLE3: DNA polymerase epsilon 3, accessory subunit. Genes, record 54107. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/54107

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Gene

Symbol
POLE3
HGNC
Name
DNA polymerase epsilon 3, accessory subunit
HGNC
NCBI Gene ID
54107
NCBI Gene
HGNC ID
HGNC:13546
HGNC
Ensembl
ENSG00000148229
NCBI Gene
Aliases
CHARAC17, CHRAC17, CHRAC2, YBL1, Ybl1, p17
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NRF9DNA polymerase epsilon subunit 31470Ensembl, GeneID, HGNC

Source UniProt

Patents27

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458455Q9NRF9Espacenet
JP 2026004568 A2026-01-1458456Q9NRF9Espacenet
EP 4650780 A22025-11-199428Q9NRF9Espacenet
EP 4641201 A22025-10-299681Q9NRF9Espacenet
JP 2025517969 A2025-06-129681Q9NRF9Espacenet
JP 2025517970 A2025-06-129428Q9NRF9Espacenet
JP 2023106701 A2023-08-0243Q9NRF9Espacenet
US 11446398 B22022-09-2064946Q9NRF9Espacenet
US 11446398 B22022-09-2064947Q9NRF9Espacenet
JP 2022524081 A2022-04-27167917Q9NRF9Espacenet

1 to 10 of 27

See all 27 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ASPACYTARABINECHEMBL4297599DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
CLOFARABINECHEMBL1750DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
CYTARABINECHEMBL803DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
FLUDARABINE PHOSPHATECHEMBL1096882DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
GEMCITABINECHEMBL888DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
GEMCITABINE HYDROCHLORIDECHEMBL1637DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
TROXACITABINECHEMBL359164DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL

Trials4,186

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07604766GEMCITABINEPHASE3ClinicalTrials.gov
NCT07604233CYTARABINEPHASE1/PHASE2ClinicalTrials.gov
NCT07603557FLUDARABINE PHOSPHATEPHASE2ClinicalTrials.gov
NCT07602140GEMCITABINEPHASE2ClinicalTrials.gov
NCT07598318GEMCITABINEPHASE2/PHASE3ClinicalTrials.gov
NCT07588360CYTARABINEClinicalTrials.gov
NCT07583888CYTARABINEPHASE2/PHASE3ClinicalTrials.gov
NCT07579195GEMCITABINEPHASE1/PHASE2ClinicalTrials.gov
NCT07575191GEMCITABINEPHASE1/PHASE2ClinicalTrials.gov
NCT07570849GEMCITABINEPHASE2ClinicalTrials.gov

1 to 10 of 4,186

See all 4,186 trials

NIH grants587

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePOLE3 papersNewest fiscal year
P30CA016672Cancer Center Support Grant62025
P30CA036727Buffett Cancer Center Support Grant42025
P20GM103427Nebraska Research Network in Functional Genomics32025
P30AI027763UCSF-Bay Area Center for AIDS Research32025
P30AI050409Center for AIDS Research at Emory University32025
R01GM134681The role of DNA damage tolerance pathways in human cells32025
R35GM118015Mechanism of Epigenetic Inheritance32025
T32CA154274Training Grant in Cancer Biology32025
P30AI027767UAB Center for AIDS Research (CFAR)22025
P30CA006973Regional Oncology Research Center22025

1 to 10 of 587Source NIH's project files

See all 587 nih grants

Papers755

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
ISWI/CHRAC orchestrates sequential chromatin-remodeling activities by mobilizing DNA polymerase ε for homologous recombination.Commun Biol202642744936PubTator, text miningPubMed
USP15 Promotes Pancreatic Cancer Progression and Cisplatin Resistance By Activating DNA Damage Repair.Mol Carcinog202641950365PubTator, text miningPubMed
Combination of Antidepressants and Chemotherapeutic Agents to Overcome P-Glycoprotein-Mediated Resistance in Cancer Patients: A Systematic Review.Med Sci (Basel)202641892841PubTator, text miningPubMed
Functional Characterization of POLE1 Variant Fibroblasts Reveals Replication Stress and Increased Sensitivity to Genotoxic Stress.Diseases202641891994PubTator, text miningPubMed
Molecular architecture and diversity of StopGo/2A translational recoding.Proc Natl Acad Sci U S A202641576085PubTator, text miningPubMed
Marine diesel engine reliable intelligent fault diagnosis method based on the generalized multi-source information fusion.iScience202641550720PubTator, text miningPubMed
Proximal proteomics analysis reveals DNA polymerase δ subunit 3 is a new MCM2 binding partner and promotes parental histones inheritance in mammalian cells.Cell Death Differ202641310184PubTator, text miningPubMed
Programmable synthesis of alkaloidal frameworks integrating Michael acceptor generates covalent probes for targeting POLE3 in HBV replication.RSC Chem Biol202641164343PubTator, text miningPubMed
The genetic and biochemical basis of human leading strand synthesis.Nat Commun202541339636PubTator, text miningPubMed
The oncolytic avian reovirus p17 protein triggers chaperone-mediated autophagy by modulating Hsp90 and the T-complex protein-1 ring complex chaperones and co-chaperones to activate the IKK/NF-κB signaling.
J Virol202541334925PubTator, text miningPubMed

1 to 10 of 755

See all 755 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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