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TREM2: triggering receptor expressed on myeloid cells 2

1 protein, 173 patents, 0 drugs, 0 trials, 4,200 NIH grants and 6,402 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTREM2HGNC
Nametriggering receptor expressed on myeloid cells 2HGNC
NCBI Gene ID54209NCBI Gene
HGNC IDHGNC:17761HGNC
EnsemblENSG00000095970NCBI Gene
AliasesAD17, PLOSL2, TREM-2, Trem2a, Trem2b, Trem2cNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q9NZC2Triggering receptor expressed on myeloid cells 223015Ensembl, GeneID, HGNCUniProt

Patents 173

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12595305 B22026-04-071Q9NZC2Espacenet
US 12595306 B22026-04-071Q9NZC2Espacenet
US 12570963 B22026-03-1057Q9NZC2Espacenet
JP 2026004568 A2026-01-1467951Q9NZC2Espacenet
US 12516298 B22026-01-0657Q9NZC2Espacenet
US 12492255 B22025-12-091Q9NZC2Espacenet
EP 4650780 A22025-11-199244Q9NZC2Espacenet
EP 4640849 A22025-10-291379Q9NZC2Espacenet
EP 4641201 A22025-10-299477Q9NZC2Espacenet
EP 4633648 A12025-10-2266Q9NZC2Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 4200

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)932,025NIH's project files
P01AG026276Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study542,025NIH's project files
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions392,025NIH's project files
P30AG066444Alzheimer's Disease Research Center342,025NIH's project files
U24AG056270National Institute on Aging Alzheimer's Disease Family-Based Study (NIA-AD FBS)252,025NIH's project files
P20GM109025Renewal of Centers of Biomedical Research Excellence (COBRE) (Phase 2) CNTN - Resubmission192,025NIH's project files
P30CA008748Cancer Center Support Grant182,025NIH's project files
U24AG041689THE NIA GENETICS OF ALZHEIMER'S DISEASE DATA STORAGE SITE172,025NIH's project files
P30AG062422New Approaches to Dementia Heterogeneity162,025NIH's project files
P30AG066509University of Washington Alzheimer's Disease Research Center162,025NIH's project files

Papers 6402

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826818PubTator, text miningPubMed
42825454PubTator, text miningPubMed
42823738PubTator, text miningPubMed
42818344PubTator, text miningPubMed
42812614PubTator, text miningPubMed
42806169PubTator, text miningPubMed
42806145PubTator, text miningPubMed
42800570PubTator, text miningPubMed
42799938PubTator, text miningPubMed
42796561PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license