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Gene · 5425

POLD2: DNA polymerase delta 2, accessory subunit

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. POLD2: DNA polymerase delta 2, accessory subunit. Genes, record 5425. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5425

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Gene

Symbol
POLD2
HGNC
Name
DNA polymerase delta 2, accessory subunit
HGNC
NCBI Gene ID
5425
NCBI Gene
HGNC ID
HGNC:9176
HGNC
Ensembl
ENSG00000106628
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P49005DNA polymerase delta subunit 24697Ensembl, GeneID, HGNC

Source UniProt

Patents47

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458441P49005Espacenet
JP 2026004568 A2026-01-1458444P49005Espacenet
EP 4650780 A22025-11-1911995P49005Espacenet
EP 4641202 A22025-10-296089P49005Espacenet
JP 2025517970 A2025-06-1211995P49005Espacenet
KR 1020250017231 A2025-02-046089P49005Espacenet
EP 4464338 A22024-11-20332P49005Espacenet
US 11680268 B22023-06-20332P49005Espacenet
US 11446398 B22022-09-2064934P49005Espacenet
US 11446398 B22022-09-2064936P49005Espacenet

1 to 10 of 47

See all 47 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ASPACYTARABINECHEMBL4297599DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
CLOFARABINECHEMBL1750DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
CYTARABINECHEMBL803DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
FLUDARABINE PHOSPHATECHEMBL1096882DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
GEMCITABINECHEMBL888DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
GEMCITABINE HYDROCHLORIDECHEMBL1637DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
TROXACITABINECHEMBL359164DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL

Trials4,186

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07604766GEMCITABINEPHASE3ClinicalTrials.gov
NCT07604233CYTARABINEPHASE1/PHASE2ClinicalTrials.gov
NCT07603557FLUDARABINE PHOSPHATEPHASE2ClinicalTrials.gov
NCT07602140GEMCITABINEPHASE2ClinicalTrials.gov
NCT07598318GEMCITABINEPHASE2/PHASE3ClinicalTrials.gov
NCT07588360CYTARABINEClinicalTrials.gov
NCT07583888CYTARABINEPHASE2/PHASE3ClinicalTrials.gov
NCT07579195GEMCITABINEPHASE1/PHASE2ClinicalTrials.gov
NCT07575191GEMCITABINEPHASE1/PHASE2ClinicalTrials.gov
NCT07570849GEMCITABINEPHASE2ClinicalTrials.gov

1 to 10 of 4,186

See all 4,186 trials

NIH grants429

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePOLD2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant42025
P30CA006927Comprehensive Cancer Center Program at Fox Chase32025
P30CA016672Cancer Center Support Grant32025
P30CA036727Buffett Cancer Center Support Grant32025
P30CA086862Cancer Center Support Grant32025
P30CA006973Regional Oncology Research Center22025
P30CA014051Cancer Center Support (Core) Grant22025
P30CA015704Cancer Center Support Grant22025
P30CA068485Cancer Center Support Grant22025
P30CA124435Stanford Cancer Institute22025

1 to 10 of 429Source NIH's project files

See all 429 nih grants

Papers485

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Comprehensive analysis of POLD2 as a potential biomarker for modulating the immune microenvironment and predicting immunotherapy response in lung adenocarcinoma.J Thorac Dis202642444900PubTator, text miningPubMed
[Transcriptomic Profile of the Trastuzumab-Resistant Breast Cancer Cell Line BT-474].Mol Biol (Mosk)202541090333PubTator, text miningPubMed
Chasing the Ghost Proteome in the Dark Matter.Mol Cell Proteomics202541033461PubTator, text miningPubMed
BOGO: A Proteome-Wide Gene Overexpression Platform for Discovering Rational Cancer Combination Therapies.bioRxiv202540950237PubTator, text miningPubMed
Using machine learning to discover DNA metabolism biomarkers that direct prostate cancer treatment.Sci Rep202540681784PubTator, text miningPubMed
Construction and validation of a prognostic model for glioma: an analysis based on mismatch repair-related genes and their correlation with clinicopathological features.Transl Cancer Res202540530129PubTator, text miningPubMed
The identification and prediction of lung adenocarcinoma prognosis using a novel gene signature associated with DNA replication.Transl Cancer Res202540224989PubTator, text miningPubMed
ASO Author Reflections: Clinical and Biological Significance of POLD2 in Lung Adenocarcinoma.Ann Surg Oncol202540126712PubTator, text miningPubMed
DNA Polymerase Delta 2 Activates Cell Cycle in Lung Adenocarcinoma, Leading to High Malignancy and Poor Prognosis.Ann Surg Oncol202540095310PubTator, text miningPubMed
Development of the TP53 mutation associated hypopharyngeal squamous cell carcinoma prognostic model through bulk multi-omics sequencing and single-cell sequencing.Braz J Otorhinolaryngol202539341197PubTator, text miningPubMed

1 to 10 of 485

See all 485 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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