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Gene · 5426

POLE: DNA polymerase epsilon, catalytic subunit

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. POLE: DNA polymerase epsilon, catalytic subunit. Genes, record 5426. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5426

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Gene

Symbol
POLE
HGNC
Name
DNA polymerase epsilon, catalytic subunit
HGNC
NCBI Gene ID
5426
NCBI Gene
HGNC ID
HGNC:9177
HGNC
Ensembl
ENSG00000177084
NCBI Gene
Aliases
CRCS12, FILS, IMAGEI, POLE1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q07864DNA polymerase epsilon catalytic subunit A2,28618Ensembl, GeneID, HGNC

Source UniProt

Patents29

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458447Q07864Espacenet
EP 4650780 A22025-11-195443Q07864Espacenet
EP 4641201 A22025-10-295047Q07864Espacenet
JP 2025517969 A2025-06-125047Q07864Espacenet
JP 2025517970 A2025-06-125443Q07864Espacenet
JP 2025039500 A2025-03-211Q07864Espacenet
US 12173335 B22024-12-2448Q07864Espacenet
EP 4464338 A22024-11-20331Q07864Espacenet
EP 4464338 A22024-11-20335Q07864Espacenet
US 11680268 B22023-06-20331Q07864Espacenet

1 to 10 of 29

See all 29 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ASPACYTARABINECHEMBL4297599DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
CLOFARABINECHEMBL1750DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
CYTARABINECHEMBL803DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
FLUDARABINE PHOSPHATECHEMBL1096882DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
GEMCITABINECHEMBL888DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
GEMCITABINE HYDROCHLORIDECHEMBL1637DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
TROXACITABINECHEMBL359164DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL

Trials4,186

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07604766GEMCITABINEPHASE3ClinicalTrials.gov
NCT07604233CYTARABINEPHASE1/PHASE2ClinicalTrials.gov
NCT07603557FLUDARABINE PHOSPHATEPHASE2ClinicalTrials.gov
NCT07602140GEMCITABINEPHASE2ClinicalTrials.gov
NCT07598318GEMCITABINEPHASE2/PHASE3ClinicalTrials.gov
NCT07588360CYTARABINEClinicalTrials.gov
NCT07583888CYTARABINEPHASE2/PHASE3ClinicalTrials.gov
NCT07579195GEMCITABINEPHASE1/PHASE2ClinicalTrials.gov
NCT07575191GEMCITABINEPHASE1/PHASE2ClinicalTrials.gov
NCT07570849GEMCITABINEPHASE2ClinicalTrials.gov

1 to 10 of 4,186

See all 4,186 trials

NIH grants310

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePOLE papersNewest fiscal year
P30CA008748Cancer Center Support Grant102025
P30CA016672Cancer Center Support Grant42025
P30CA036727Buffett Cancer Center Support Grant32025
R01ES028271Investigation of human DNA polymerase epsilon variants32025
ZIAAI000646Transgenic Animal Models Of Human Immune Defects32025
ZIAAI000647Genes And Gene Products As Immunoadjuvants32025
P20GM103427Nebraska Research Network in Functional Genomics22025
P30CA016058Cancer Center Support Grant22025
P30CA016359Cancer Center Support Grant22025
P30CA047904Cancer Center Support Grant22025

1 to 10 of 310Source NIH's project files

See all 310 nih grants

Papers392

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
DNA polymerase epsilon catalytic subunit (POLE) in cancer: Implications for tumor biology and therapeutic strategies - A comprehensive review.Crit Rev Oncol Hematol202642386138PubTator, text miningPubMed
Functional Characterization of POLE1 Variant Fibroblasts Reveals Replication Stress and Increased Sensitivity to Genotoxic Stress.Diseases202641891994PubTator, text miningPubMed
Leveraging sequences missing from the human genome to diagnose cancer.Commun Med (Lond)202540841759PubTator, text miningPubMed
Ultrasound and gene-guided microwave ablation vs. surgery for low-risk papillary thyroid carcinoma: a prospective observational cohort study.Precis Clin Med202540385102PubTator, text miningPubMed
ERBB2 mutations define a subgroup of endometrial carcinomas associated with high tumor mutational burden and the microsatellite instability-high (MSI-H) molecular subtype.Mol Oncol202439031567PubTator, text miningPubMed
Immunotherapy for Solitary Fibrous Tumor (Hemangiopericytoma): A Unique Treatment Approach for a Rare Central Nervous System Tumor.Neurologist202438797934PubTator, text miningPubMed
Genetic mutation profiling reveals biomarkers for targeted therapy efficacy and prognosis in non-small cell lung cancer.Heliyon202438496877PubTator, text miningPubMed
Race, Prevalence of POLE and POLD1 Alterations, and Survival Among Patients With Endometrial Cancer.JAMA Netw Open202438231514PubTator, text miningPubMed
Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish.Commun Biol202438182651PubTator, text miningPubMed
Congenital anaemia associated with loss-of-function variants in DNA polymerase epsilon 1.J Med Genet202437833059PubTator, text miningPubMed

1 to 10 of 392

See all 392 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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