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Gene · 5428

POLG: DNA polymerase gamma, catalytic subunit

11 sourcesgene-search-2026-11-11-0.1.0

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ConductScience Library. POLG: DNA polymerase gamma, catalytic subunit. Genes, record 5428. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/5428

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Gene

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

Symbol
POLG
HGNC
Name
DNA polymerase gamma, catalytic subunit
HGNC
NCBI Gene ID
5428
NCBI Gene
HGNC ID
HGNC:9179
HGNC
Ensembl
ENSG00000140521
NCBI Gene
Aliases
MIRAS, MTDPS4A, MTDPS4B, PEO, POLG1, POLGA, PolG-alpha, SANDO, SCAE
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P54098DNA polymerase subunit gamma-11,23936Ensembl, GeneID, HGNC

Source UniProt

Patents39

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21167P54098Espacenet
JP 2026004568 A2026-01-1458461P54098Espacenet
JP 2026004568 A2026-01-1458462P54098Espacenet
EP 4641201 A22025-10-292227P54098Espacenet
US 12435331 B22025-10-0762P54098Espacenet
JP 2025517969 A2025-06-122227P54098Espacenet
US 12173335 B22024-12-2451P54098Espacenet
JP 2023549167 A2023-11-22224P54098Espacenet
JP 2023113627 A2023-08-1662P54098Espacenet
JP 2023521663 A2023-05-25166P54098Espacenet

1 to 10 of 39

See all 39 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,579

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal year
ZIAES065078Molecular Characterization Of The Mitochondrial Dna Polymerase662025
ZIAES065080Human Mitochondrial Dna Polymerase With Anti-hiv Nucleotides272025
P01CA092584Structural Cell Biology of DNA Repair Machines122025
P30AI050409Center for AIDS Research at Emory University102025
P30CA016672Cancer Center Support Grant102025
R01EY010804Setting the Stage for Replacement of Mitochondrial Genes102025
P30CA008748Cancer Center Support Grant92025
P30CA016056Roswell Park Cancer Center Support Grant92025
R01NS083726Personalized Functional Genomics for Mitochondrial Encephalopathy Gene Discovery92025
P42ES010356Duke University Superfund Research Center - Developmental Co-Exposures: Mechanisms, Outcomes, and Remediation82025

1 to 10 of 2,579Source NIH's project files

See all 2,579 nih grants

Papers4,408

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42788360PubTator, text miningPubMed
42742376PubTator, text miningPubMed
42727251PubTator, text miningPubMed
42722560PubTator, text miningPubMed
42713573PubTator, text miningPubMed
42699627PubTator, text miningPubMed
42650043PubTator, text miningPubMed
42635616PubTator, text miningPubMed
42623939PubTator, text miningPubMed
42606642PubTator, text miningPubMed

1 to 10 of 4,408

See all 4,408 papers

Sources 11

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNone stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GeneNone named. Public domain as US government information
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5428

GET https://conductscience.org/api/genes/v1/5428/patents?page=2