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Gene · 5430

POLR2A: RNA polymerase II subunit A

11 sourcesgene-search-2026-11-11-0.1.0

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ConductScience Library. POLR2A: RNA polymerase II subunit A. Genes, record 5430. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/5430

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Gene

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

Symbol
POLR2A
HGNC
Name
RNA polymerase II subunit A
HGNC
NCBI Gene ID
5430
NCBI Gene
HGNC ID
HGNC:9187
HGNC
Ensembl
ENSG00000181222
NCBI Gene
Aliases
NEDHIB, POLR2, POLRA, RPB1, RPBh1, RPO2, RPOL2, RpIILS, hRPB220, hsRPB1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P24928DNA-directed RNA polymerase II subunit RPB11,97056GeneID, HGNC

Source UniProt

Patents13

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 11827938 B22023-11-2849P24928Espacenet
US 11446398 B22022-09-2065051P24928Espacenet
JP 2022524081 A2022-04-27168022P24928Espacenet
EP 3866835 A12021-08-25184P24928Espacenet
US 11078247 B22021-08-038720P24928Espacenet
EP 3504344 A12019-07-031518P24928Espacenet
JP 2018527883 A2018-09-27197P24928Espacenet
JP 2018521637 A2018-08-0976P24928Espacenet
US 7833736 B22010-11-1610P24928Espacenet
EP 2118321 A22009-11-18475P24928Espacenet

1 to 10 of 13

See all 13 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants3,249

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal year
P30CA008748Cancer Center Support Grant282025
P30CA016672Cancer Center Support Grant172025
UL1TR001863Yale Clinical and Translational Science Award142025
P30CA010815Consolidated Basic Cancer Research Program122025
P30CA046934University of Colorado Cancer Center Support Grant122025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant112025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center112025
P30CA086862Cancer Center Support Grant102025
P30CA006973Regional Oncology Research Center92025
R01GM056663mRNA Capping Enzyme92025

1 to 10 of 3,249Source NIH's project files

See all 3,249 nih grants

Papers4,359

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826470PubTator, text miningPubMed
42763634PubTator, text miningPubMed
42671029PubTator, text miningPubMed
42655648PubTator, text miningPubMed
42624930PubTator, text miningPubMed
42546114PubTator, text miningPubMed
42536723PubTator, text miningPubMed
42526351PubTator, text miningPubMed
42524026PubTator, text miningPubMed
42481107PubTator, text miningPubMed

1 to 10 of 4,359

See all 4,359 papers

Sources 11

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNone stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GeneNone named. Public domain as US government information
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5430

GET https://conductscience.org/api/genes/v1/5430/patents