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Gene · 5431

POLR2B: RNA polymerase II subunit B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. POLR2B: RNA polymerase II subunit B. Genes, record 5431. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5431

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Gene

Symbol
POLR2B
HGNC
Name
RNA polymerase II subunit B
HGNC
NCBI Gene ID
5431
NCBI Gene
HGNC ID
HGNC:9188
HGNC
Ensembl
ENSG00000047315
NCBI Gene
Aliases
POL2RB, RPB2, hRPB140
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P30876DNA-directed RNA polymerase II subunit RPB21,17420Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-194863P30876Espacenet
EP 4641201 A22025-10-294430P30876Espacenet
JP 2025517969 A2025-06-124430P30876Espacenet
JP 2025517970 A2025-06-124863P30876Espacenet
JP 2022141755 A2022-09-29735P30876Espacenet
US 11446398 B22022-09-2065052P30876Espacenet
US 11446398 B22022-09-2065053P30876Espacenet
JP 2022524081 A2022-04-27168023P30876Espacenet
JP 2022524081 A2022-04-27168024P30876Espacenet
US 11078247 B22021-08-038721P30876Espacenet

1 to 10 of 31

See all 31 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants684

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePOLR2B papersNewest fiscal year
R01GM102362Molecular Mechanisms for DNA Damage Processing by Transcription Machinery92025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center52025
P01CA092584Structural Cell Biology of DNA Repair Machines42025
P30CA016058Cancer Center Support Grant32025
R01CA136367Disruption of Cellular RNA Processing by Kaposi's Sarcoma-Associated Herpesvirus32025
R01HL098316Mechanism and regulation of DNA interstrand cross-link repair32025
P01CA125066Discovery of Anticancer Agents of Diverse Natural Origin22025
P30CA016086Cancer Center Support Grant22025
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant22025
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)22025

1 to 10 of 684Source NIH's project files

See all 684 nih grants

Papers1,755

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
New discoveries of Lanonia (Arecaceae) from northern Vietnam and southwestern China.PhytoKeys202642798846PubTator, text miningPubMed
A novel Cryphonectria species (Cryphonectriaceae, Diaporthales) discovered on Eucalyptus, including insights into the mating biology of the genus.Fungal Biol202642668170PubTator, text miningPubMed
Phylogenetic and Phylogenomic Analyses Reveal New Taxa in Clitocybaceae, with Notes on Poisonous Species and Spore Evolution.J Fungi (Basel)202642646075PubTator, text miningPubMed
Novel insights into the phylogenetic and metabolic diversity of preussia-like fungi.Stud Mycol202642609470PubTator, text miningPubMed
Structure of human cytoplasmic Pol II complex explains global transcription repression by GDOWN1.Nat Commun202642557252PubTator, text miningPubMed
Six newly described Inocybaceae from North America.Mycologia202642546114PubTator, text miningPubMed
An Updated Taxonomy of Talaromyces (Trichocomaceae, Eurotiales): New Series and Species.J Fungi (Basel)202642506247PubTator, text miningPubMed
Morphological and phylogenetic characterization of two Rosellinia subgenus Corrugata species causing disease on conifers in temperate forests of the United States.Mycologia202642490190PubTator, text miningPubMed
Disentangling the phylogeny of bladderworts (Utricularia sect. Utricularia: Lentibulariaceae) based on plastid and nuclear data.Plant Biol (Stuttg)202642415482PubTator, text miningPubMed
Taxonomy and molecular evaluation of the Halosphaeriaceae (Microascales, Hypocreomycetidae).MycoKeys202642403426PubTator, text miningPubMed

1 to 10 of 1,755

See all 1,755 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5431

GET https://conductscience.org/api/genes/v1/5431/patents?page=2