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Gene · 54363

HAO1: hydroxyacid oxidase 1

11 sourcesgene-search-2026-11-11-0.1.0

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ConductScience Library. HAO1: hydroxyacid oxidase 1. Genes, record 54363. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/54363

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Gene

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

Symbol
HAO1
HGNC
Name
hydroxyacid oxidase 1
HGNC
NCBI Gene ID
54363
NCBI Gene
HGNC ID
HGNC:4809
HGNC
Ensembl
ENSG00000101323
NCBI Gene
Aliases
GO, GOX, GOX1, GYCA, HAOX1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UJM82-Hydroxyacid oxidase 137021Ensembl, GeneID, HGNC

Source UniProt

Patents24

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1449506Q9UJM8Espacenet
EP 4650780 A22025-11-1910085Q9UJM8Espacenet
EP 4641201 A22025-10-2910379Q9UJM8Espacenet
JP 2025517969 A2025-06-1210379Q9UJM8Espacenet
JP 2025517970 A2025-06-1210085Q9UJM8Espacenet
EP 4555087 A22025-05-2150Q9UJM8Espacenet
JP 2024519469 A2024-05-1465Q9UJM8Espacenet
KR 1020240001708 A2024-01-0350Q9UJM8Espacenet
US 11446398 B22022-09-2039171Q9UJM8Espacenet
JP 2022524081 A2022-04-27142142Q9UJM8Espacenet

1 to 10 of 24

See all 24 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
LUMASIRANCHEMBL4297779Hydroxyacid oxidase 1 mRNA RNAi inhibitorRNAI INHIBITORChEMBL
LUMASIRAN SODIUMCHEMBL4650275Hydroxyacid oxidase 1 mRNA RNAi inhibitorRNAI INHIBITORChEMBL

Trials8

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06225882LUMASIRANClinicalTrials.gov
NCT06225544LUMASIRANPHASE2ClinicalTrials.gov
NCT04152200LUMASIRANPHASE32022-07-12ClinicalTrials.gov
NCT04125472LUMASIRANClinicalTrials.gov
NCT03905694LUMASIRANPHASE32021-07-19ClinicalTrials.gov
NCT03681184LUMASIRANPHASE32021-01-19ClinicalTrials.gov
NCT03350451LUMASIRANPHASE22024-04-25ClinicalTrials.gov
NCT02706886LUMASIRANPHASE1/PHASE22020-01-30ClinicalTrials.gov

NIH grants701

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal year
R01CA225958Novel bioengineered microRNA therapeutics for lung cancer42025
P01CA092584Structural Cell Biology of DNA Repair Machines32025
P30CA093373Cancer Center Support Grant P3032025
P30CA014051Cancer Center Support (Core) Grant22025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)22025
P30CA014520UW Comprehensive Cancer Center Support22025
P30CA015704Cancer Center Support Grant22025
P30CA068485Cancer Center Support Grant22025
P30CA072720Cancer Center Support Grant22025
P30DK058404Molecular and Cellular Basis for Digestive Diseases22025

1 to 10 of 701Source NIH's project files

See all 701 nih grants

Papers4,548

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825802PubTator, text miningPubMed
42822783PubTator, text miningPubMed
42822127PubTator, text miningPubMed
42821106PubTator, text miningPubMed
42815604PubTator, text miningPubMed
42800156PubTator, text miningPubMed
42796121PubTator, text miningPubMed
42790414PubTator, text miningPubMed
42777541PubTator, text miningPubMed
42775556PubTator, text miningPubMed

1 to 10 of 4,548

See all 4,548 papers

Sources 11

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNone stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GeneNone named. Public domain as US government information
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/54363

GET https://conductscience.org/api/genes/v1/54363/patents?page=2