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Gene · 54386

TERF2IP: TERF2 interacting protein

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TERF2IP: TERF2 interacting protein. Genes, record 54386. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/54386

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Gene

Symbol
TERF2IP
HGNC
Name
TERF2 interacting protein
HGNC
NCBI Gene ID
54386
NCBI Gene
HGNC ID
HGNC:19246
HGNC
Ensembl
ENSG00000166848
NCBI Gene
Aliases
DRIP5, RAP1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NYB0Telomeric repeat-binding factor 2-interacting protein 13995Ensembl, GeneID, HGNC

Source UniProt

Patents23

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4704859 A12026-03-111Q9NYB0Espacenet
EP 4650780 A22025-11-193980Q9NYB0Espacenet
EP 4640849 A22025-10-29516Q9NYB0Espacenet
EP 4641201 A22025-10-293561Q9NYB0Espacenet
JP 2025519096 A2025-06-24516Q9NYB0Espacenet
JP 2025517969 A2025-06-123561Q9NYB0Espacenet
JP 2025517970 A2025-06-123980Q9NYB0Espacenet
JP 2024123008 A2024-09-108632Q9NYB0Espacenet
US 11446398 B22022-09-2087589Q9NYB0Espacenet
JP 2022524081 A2022-04-27190560Q9NYB0Espacenet

1 to 10 of 23

See all 23 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,134

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTERF2IP papersNewest fiscal year
R01AG016642Mechanism of the telomeric proliferation limit182025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant92025
P30CA016672Cancer Center Support Grant82025
ZIACP010190Genetic Epidemiology of Telomere Maintenance and Cancer Etiology72025
P30CA008748Cancer Center Support Grant62025
P30ES009089Center for Environmental Health in Northern Manhattan62025
P30CA014195Cancer Center Support Grant (CCSG)52025
P30ES025128Center for Human Health and the Environment (CHHE)52025
R35CA210036Genome instability in cancer: telomeres and DNA repair52025
ZIACP004410Family Studies52025

1 to 10 of 1,134Source NIH's project files

See all 1,134 nih grants

Papers1,658

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
DHODH inhibition drives albumin-mediated drug resistance through TERF2IP lactylation-activated macropinosome-mitochondria contact.Nat Commun202642736281PubTator, text miningPubMed
Non-Telomeric Role of RAP1 in Facilitating NF-κB Activation and Driving Hepatocellular Carcinoma Progression.IUBMB Life202642458663PubTator, text miningPubMed
The Role of Genetics in Malignant Melanoma: A Comprehensive Review.Surg Clin North Am202642419313PubTator, text miningPubMed
Prevalence of Familial Melanoma Genes and Cancer Risk Among Genomically Ascertained Individuals.JAMA Dermatol202642201696PubTator, text miningPubMed
Structural basis for TRF2-RAP1 recruitment by EBNA1 at the EBV origin of replication.Sci Rep202641957069PubTator, text miningPubMed
TRF2-RAP1 inhibits homology-directed repair of telomeres by promoting BLM-mediated removal of telomere R-loops.Nucleic Acids Res202641914496PubTator, text miningPubMed
Micronuclei: origins, assays, mechanisms, diseases and treatments.Signal Transduct Target Ther202641888103PubTator, text miningPubMed
Machine learning identifies a DNA repair-related risk model for bladder cancer and functionally characterizes ZWINT as a potential oncogenic factor.Transl Androl Urol202641809788PubTator, text miningPubMed
DAB2IP: unifying cardiovascular pathogenesis and cardiovascular brain crosstalk.Front Cardiovasc Med202641798622PubTator, text miningPubMed
Exosome-delivered bioactive molecules regulate macrophage polarization in atherosclerosis and myocardial infarction: mechanisms and therapeutic potential.Front Cardiovasc Med202641798608PubTator, text miningPubMed

1 to 10 of 1,658

See all 1,658 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/54386

GET https://conductscience.org/api/genes/v1/54386/patents?page=2