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Gene · 54464

XRN1: 5'-3' exoribonuclease 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. XRN1: 5'-3' exoribonuclease 1. Genes, record 54464. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/54464

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Gene

Symbol
XRN1
HGNC
Name
5'-3' exoribonuclease 1
HGNC
NCBI Gene ID
54464
NCBI Gene
HGNC ID
HGNC:30654
HGNC
Ensembl
ENSG00000114127
NCBI Gene
Aliases
SEP1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8IZH25'-3' exoribonuclease 11,7061Ensembl, GeneID, HGNC

Source UniProt

Patents23

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-192418Q8IZH2Espacenet
EP 4641201 A22025-10-291996Q8IZH2Espacenet
JP 2025517969 A2025-06-121996Q8IZH2Espacenet
JP 2025517970 A2025-06-122418Q8IZH2Espacenet
JP 2025062604 A2025-04-14348Q8IZH2Espacenet
JP 2024123008 A2024-09-104715Q8IZH2Espacenet
US 11459613 B22022-10-0460Q8IZH2Espacenet
US 11446398 B22022-09-20348Q8IZH2Espacenet
JP 2022524081 A2022-04-27103319Q8IZH2Espacenet
WO 2020043864 A12020-03-052847Q8IZH2Espacenet

1 to 10 of 23

See all 23 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,191

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleXRN1 papersNewest fiscal year
R01CA136367Disruption of Cellular RNA Processing by Kaposi's Sarcoma-Associated Herpesvirus172025
R01AI133348Mechanisms of viral RNA maturation by co-opting cellular exonucleases92025
P30CA046934University of Colorado Cancer Center Support Grant72025
R35GM118070Structure, function, and dynamics of viral RNAs and RNA-containing complexes72025
P20GM130423The Kansas Institute for Precision Medicine52025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant52025
P41EB020594Biotechnology Resource Center of BioModular Multi-scale Systems (CBM2) for Precision Medicine52025
R01AI067380Quasispecies dynamics in arbovirus persistence emergence and fitness52025
R01DK057819Intestinal Mucosal Growth in Health and Surgical Diseases52025
R01GM056927Control of Translation in Herpesvirus Infected Cells - Resubmission - 152025

1 to 10 of 1,191Source NIH's project files

See all 1,191 nih grants

Papers1,652

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
XRN1-Resistant Elements Are Located in the 3'-Terminal Regions of Certain Genome Segments of Jingmenviruses.Viruses202642797779PubTator, text miningPubMed
N4BP1 uses tandem KH domains to associate with EDC4 and mRNA decapping factors in P-bodies.Commun Biol202642754686PubTator, text miningPubMed
Phosphoproteomics identifies the DYRK1B protein kinase as a regulator of processing bodies.J Cell Sci202642592723PubTator, text miningPubMed
DIS3L2 and Nonsense-mediated Decay: United to Degrade.J Mol Biol202642442601PubTator, text miningPubMed
Comparative analysis of flavivirus sfRNA dynamics and secondary structure.J Virol202642429625PubTator, text miningPubMed
Plastic Nanofluidic Sensor with a Solid-Phase Bioreactor and Dual Nanopore Reader: Studying Biological Reactions at the Single-Molecule Level.ACS Appl Mater Interfaces202642367095PubTator, text miningPubMed
Exploration of candidate genes associated with rare SNVs in pulmonary stenosis using whole-exome sequencing and machine learning.Front Genet202642326386PubTator, text miningPubMed
A key role for the exoribonuclease XRN1 in regulating the hepatitis B viral transcriptome.iScience202642325577PubTator, text miningPubMed
Rational design of mechanically active RNAs: de novo engineering of functional exoribonuclease-resistant RNAs.Nucleic Acids Res202642120043PubTator, text miningPubMed
The long isoform of ZAP coordinates multiple enzymes to mediate complete decay of target transcripts.Cell Rep202642054207PubTator, text miningPubMed

1 to 10 of 1,652

See all 1,652 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/54464

GET https://conductscience.org/api/genes/v1/54464/patents?page=2