Gene · 54464
XRN1: 5'-3' exoribonuclease 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. XRN1: 5'-3' exoribonuclease 1. Genes, record 54464. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/54464
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q8IZH2 | 5'-3' exoribonuclease 1 | 1,706 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents23
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 2418 | Q8IZH2 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1996 | Q8IZH2 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1996 | Q8IZH2 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2418 | Q8IZH2 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 348 | Q8IZH2 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 4715 | Q8IZH2 | Espacenet |
| US 11459613 B2 | 2022-10-04 | 60 | Q8IZH2 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 348 | Q8IZH2 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 103319 | Q8IZH2 | Espacenet |
| WO 2020043864 A1 | 2020-03-05 | 2847 | Q8IZH2 | Espacenet |
1 to 10 of 23
See all 23 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,191
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | XRN1 papers | Newest fiscal year |
|---|---|---|---|
| R01CA136367 | Disruption of Cellular RNA Processing by Kaposi's Sarcoma-Associated Herpesvirus | 17 | 2025 |
| R01AI133348 | Mechanisms of viral RNA maturation by co-opting cellular exonucleases | 9 | 2025 |
| P30CA046934 | University of Colorado Cancer Center Support Grant | 7 | 2025 |
| R35GM118070 | Structure, function, and dynamics of viral RNAs and RNA-containing complexes | 7 | 2025 |
| P20GM130423 | The Kansas Institute for Precision Medicine | 5 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 5 | 2025 |
| P41EB020594 | Biotechnology Resource Center of BioModular Multi-scale Systems (CBM2) for Precision Medicine | 5 | 2025 |
| R01AI067380 | Quasispecies dynamics in arbovirus persistence emergence and fitness | 5 | 2025 |
| R01DK057819 | Intestinal Mucosal Growth in Health and Surgical Diseases | 5 | 2025 |
| R01GM056927 | Control of Translation in Herpesvirus Infected Cells - Resubmission - 1 | 5 | 2025 |
1 to 10 of 1,191Source NIH's project files
See all 1,191 nih grantsPapers1,652
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| XRN1-Resistant Elements Are Located in the 3'-Terminal Regions of Certain Genome Segments of Jingmenviruses. | Viruses | 2026 | 42797779 | PubTator, text mining | PubMed |
| N4BP1 uses tandem KH domains to associate with EDC4 and mRNA decapping factors in P-bodies. | Commun Biol | 2026 | 42754686 | PubTator, text mining | PubMed |
| Phosphoproteomics identifies the DYRK1B protein kinase as a regulator of processing bodies. | J Cell Sci | 2026 | 42592723 | PubTator, text mining | PubMed |
| DIS3L2 and Nonsense-mediated Decay: United to Degrade. | J Mol Biol | 2026 | 42442601 | PubTator, text mining | PubMed |
| Comparative analysis of flavivirus sfRNA dynamics and secondary structure. | J Virol | 2026 | 42429625 | PubTator, text mining | PubMed |
| Plastic Nanofluidic Sensor with a Solid-Phase Bioreactor and Dual Nanopore Reader: Studying Biological Reactions at the Single-Molecule Level. | ACS Appl Mater Interfaces | 2026 | 42367095 | PubTator, text mining | PubMed |
| Exploration of candidate genes associated with rare SNVs in pulmonary stenosis using whole-exome sequencing and machine learning. | Front Genet | 2026 | 42326386 | PubTator, text mining | PubMed |
| A key role for the exoribonuclease XRN1 in regulating the hepatitis B viral transcriptome. | iScience | 2026 | 42325577 | PubTator, text mining | PubMed |
| Rational design of mechanically active RNAs: de novo engineering of functional exoribonuclease-resistant RNAs. | Nucleic Acids Res | 2026 | 42120043 | PubTator, text mining | PubMed |
| The long isoform of ZAP coordinates multiple enzymes to mediate complete decay of target transcripts. | Cell Rep | 2026 | 42054207 | PubTator, text mining | PubMed |
1 to 10 of 1,652
See all 1,652 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/54464
GET https://conductscience.org/api/genes/v1/54464/patents?page=2