Gene · 54472
TOLLIP: toll interacting protein
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TOLLIP: toll interacting protein. Genes, record 54472. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/54472
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9H0E2 | Toll-interacting protein | 274 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents33
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 4971 | Q9H0E2 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 4556 | Q9H0E2 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 4556 | Q9H0E2 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 4971 | Q9H0E2 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 8727 | Q9H0E2 | Espacenet |
| JP 2023123507 A | 2023-09-05 | 192 | Q9H0E2 | Espacenet |
| US 11666661 B2 | 2023-06-06 | 16 | Q9H0E2 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 89138 | Q9H0E2 | Espacenet |
| JP 2022537339 A | 2022-08-25 | 129 | Q9H0E2 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 192109 | Q9H0E2 | Espacenet |
1 to 10 of 33
See all 33 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants974
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TOLLIP papers | Newest fiscal year |
|---|---|---|---|
| U19AI125357 | Innate Immunity and Viral Infection in Asthma | 8 | 2025 |
| P30DK040561 | Boston Area Nutrition Obesity Research Center (NORC) | 6 | 2025 |
| P30DK043351 | Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital | 6 | 2025 |
| T32HL007085 | Multi-Disciplinary Research Training in Respiratory Disease | 5 | 2025 |
| P01AI063302 | The intersection of innate and adaptive immunity to intracellular pathogens | 3 | 2025 |
| T32AI007044 | Host Defense Training in Allergy and Infectious Diseases | 3 | 2025 |
| U19AI135972 | SARS-CoV adaptations through a Systems Biology Lens (SYBIL) | 3 | 2025 |
| U19AI135990 | HPMI: Host Pathogen Mapping Initiative | 3 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 3 | 2025 |
| KL2TR001870 | Institutional Career Development Core | 2 | 2025 |
1 to 10 of 974Source NIH's project files
See all 974 nih grantsPapers1,377
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Peripheral immune checkpoint gene expression as diagnostic biomarkers in idiopathic pulmonary fibrosis. | Sarcoidosis Vasc Diffuse Lung Dis | 2026 | 42813315 | PubTator, text mining | PubMed |
| TOLLIP suppresses picornavirus internalization by targeting and degrading VP1 protein through selective autophagy. | Autophagy | 2026 | 42604494 | PubTator, text mining | PubMed |
Retraction notice to "Mechanism research of Tollip negative feedback regulation in TLR4 signaling pathways based on spinal tuberculosis: Detection of Tollip and NF-κB expression levels" [Int. J. Biol. Macromol. 281 (2024) 136458]. | Int J Biol Macromol | 2026 | 42538202 | PubTator, text mining | PubMed |
| TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2-Mediated Glycolysis in Keratinocytes. | Adv Sci (Weinh) | 2026 | 42535771 | PubTator, text mining | PubMed |
| The PCK2-Traf6-Tollip Axis Restricts PEDV Replication by Orchestrating Selective Autophagic Degradation of the Viral Nucleocapsid Protein. | Transbound Emerg Dis | 2026 | 42374836 | PubTator, text mining | PubMed |
| Coronavirus M Protein Hijacks Toll-Interacting Protein (TOLLIP) to Suppress NF-κB Signaling and Promote Immune Evasion. | MedComm (2020) | 2026 | 42318529 | PubTator, text mining | PubMed |
| Cleavage of TOM1 by the SARS-CoV-2 main protease NSP5 prevents autophagic degradation of viral envelope. | J Virol | 2026 | 42283626 | PubTator, text mining | PubMed |
| Toll interacting protein (TOLLIP) serum concentration in patients with systemic sclerosis (SSc), with and without interstitial lung disease (ILD). | BMJ Open Respir Res | 2026 | 42264885 | PubTator, text mining | PubMed |
| TOM1 family proteins: from cargo sorting to immune dysregulation and cancer. | Cell Commun Signal | 2026 | 42192436 | PubTator, text mining | PubMed |
| Tollip antagonizes ESCRT-III-mediated plasma membrane repair and cell recovery. | Cell Regen | 2026 | 42154192 | PubTator, text mining | PubMed |
1 to 10 of 1,377
See all 1,377 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/54472
GET https://conductscience.org/api/genes/v1/54472/patents?page=2