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Gene · 54472

TOLLIP: toll interacting protein

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TOLLIP: toll interacting protein. Genes, record 54472. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/54472

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Gene

Symbol
TOLLIP
HGNC
Name
toll interacting protein
HGNC
NCBI Gene ID
54472
NCBI Gene
HGNC ID
HGNC:16476
HGNC
Ensembl
ENSG00000078902
NCBI Gene
Aliases
IL-1RAcPIP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9H0E2Toll-interacting protein2742Ensembl, GeneID, HGNC

Source UniProt

Patents33

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-194971Q9H0E2Espacenet
EP 4641201 A22025-10-294556Q9H0E2Espacenet
JP 2025517969 A2025-06-124556Q9H0E2Espacenet
JP 2025517970 A2025-06-124971Q9H0E2Espacenet
JP 2024123008 A2024-09-108727Q9H0E2Espacenet
JP 2023123507 A2023-09-05192Q9H0E2Espacenet
US 11666661 B22023-06-0616Q9H0E2Espacenet
US 11446398 B22022-09-2089138Q9H0E2Espacenet
JP 2022537339 A2022-08-25129Q9H0E2Espacenet
JP 2022524081 A2022-04-27192109Q9H0E2Espacenet

1 to 10 of 33

See all 33 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants974

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTOLLIP papersNewest fiscal year
U19AI125357Innate Immunity and Viral Infection in Asthma82025
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)62025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital62025
T32HL007085Multi-Disciplinary Research Training in Respiratory Disease52025
P01AI063302The intersection of innate and adaptive immunity to intracellular pathogens32025
T32AI007044Host Defense Training in Allergy and Infectious Diseases32025
U19AI135972SARS-CoV adaptations through a Systems Biology Lens (SYBIL)32025
U19AI135990HPMI: Host Pathogen Mapping Initiative32025
UL1TR001863Yale Clinical and Translational Science Award32025
KL2TR001870Institutional Career Development Core22025

1 to 10 of 974Source NIH's project files

See all 974 nih grants

Papers1,377

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Peripheral immune checkpoint gene expression as diagnostic biomarkers in idiopathic pulmonary fibrosis.Sarcoidosis Vasc Diffuse Lung Dis202642813315PubTator, text miningPubMed
TOLLIP suppresses picornavirus internalization by targeting and degrading VP1 protein through selective autophagy.Autophagy202642604494PubTator, text miningPubMed
Retraction notice to "Mechanism research of Tollip negative feedback regulation in TLR4 signaling pathways based on spinal tuberculosis: Detection of Tollip and NF-κB expression levels" [Int. J. Biol. Macromol. 281 (2024) 136458].
Int J Biol Macromol202642538202PubTator, text miningPubMed
TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2-Mediated Glycolysis in Keratinocytes.Adv Sci (Weinh)202642535771PubTator, text miningPubMed
The PCK2-Traf6-Tollip Axis Restricts PEDV Replication by Orchestrating Selective Autophagic Degradation of the Viral Nucleocapsid Protein.Transbound Emerg Dis202642374836PubTator, text miningPubMed
Coronavirus M Protein Hijacks Toll-Interacting Protein (TOLLIP) to Suppress NF-κB Signaling and Promote Immune Evasion.MedComm (2020)202642318529PubTator, text miningPubMed
Cleavage of TOM1 by the SARS-CoV-2 main protease NSP5 prevents autophagic degradation of viral envelope.J Virol202642283626PubTator, text miningPubMed
Toll interacting protein (TOLLIP) serum concentration in patients with systemic sclerosis (SSc), with and without interstitial lung disease (ILD).BMJ Open Respir Res202642264885PubTator, text miningPubMed
TOM1 family proteins: from cargo sorting to immune dysregulation and cancer.Cell Commun Signal202642192436PubTator, text miningPubMed
Tollip antagonizes ESCRT-III-mediated plasma membrane repair and cell recovery.Cell Regen202642154192PubTator, text miningPubMed

1 to 10 of 1,377

See all 1,377 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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