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Gene · 5449

POU1F1: POU class 1 homeobox 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. POU1F1: POU class 1 homeobox 1. Genes, record 5449. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5449

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Gene

Symbol
POU1F1
HGNC
Name
POU class 1 homeobox 1
HGNC
NCBI Gene ID
5449
NCBI Gene
HGNC ID
HGNC:9210
HGNC
Ensembl
ENSG00000064835
NCBI Gene
Aliases
CPHD1, GHF-1, PIT-1, PIT1, POU1F1a, Pit-1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P28069Pituitary-specific positive transcription factor 12911Ensembl, GeneID, HGNC

Source UniProt

Patents29

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458828P28069Espacenet
EP 4641201 A22025-10-291822P28069Espacenet
JP 2025147176 A2025-10-0615501P28069Espacenet
JP 2025517969 A2025-06-121822P28069Espacenet
JP 2025028160 A2025-02-2815501P28069Espacenet
KR 1020250010750 A2025-01-2115501P28069Espacenet
JP 2024109657 A2024-08-1415340P28069Espacenet
US 11446398 B22022-09-2065954P28069Espacenet
JP 2022524081 A2022-04-27168925P28069Espacenet
JP 2021536249 A2021-12-2715694P28069Espacenet

1 to 10 of 29

See all 29 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,028

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePOU1F1 papersNewest fiscal year
R01DK018477Enhancer Connectomes in Regulation of Gene Expression132025
T32HL007828Cardiovascular Research Training Program72025
P01CA013106Targeting Transcription and Splicing in Cancer62025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202862025
P30DK019525University of Pennsylvania Diabetes Research Center52025
P01CA100730Retrovirus Models of Cancer42025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant42025
ZIABC010441Biomolecular Recognition and Binding Mechanisms42025
P30CA008748Cancer Center Support Grant32025
P30CA016056Roswell Park Cancer Center Support Grant32025

1 to 10 of 1,028Source NIH's project files

See all 1,028 nih grants

Papers2,504

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Deep Learning Based on Magnetic Resonance Imaging for Preoperative Prediction of Pituitary Neuroendocrine Tumors Subtypes.Acad Radiol202642736093PubTator, text miningPubMed
Case Report: Development of a thyrotropinoma in a patient with thyroid hemiagenesis.Front Endocrinol (Lausanne)202642723820PubTator, text miningPubMed
What do you mean by PitNETs in WHO Classification 2022?Endocr J202642702553PubTator, text miningPubMed
Differential expression of cyclin D1 in pituitary neuroendocrine tumours: Relation to aggressive potential.Afr J Lab Med202642699363PubTator, text miningPubMed
Radiomics and artificial intelligence in pituitary adenomas (PitNETs): from imaging biomarkers to clinical translation.Rev Endocr Metab Disord202642684588PubTator, text miningPubMed
Multiparametric MRI-Based Ensemble Deep Learning for Preoperative Classification of Pituitary Neuroendocrine Tumor Subtypes.Acad Radiol202642680659PubTator, text miningPubMed
Cushing disease caused by a TBX19/PIT1 co-expressing pituitary adenoma/pituitary neuroendocrine tumor.J Neuropathol Exp Neurol202642658565PubTator, text miningPubMed
Integrin αvβ6 Expression in the Human Pituitary Gland and Pituitary Neuroendocrine Tumors: Immunohistochemical Characterization with Potential Relevance to αvβ6 PET/CT Pituitary Uptake and Theranostic Implications.
Biomolecules202642650848PubTator, text miningPubMed
Comparative analysis of SCGN expression patterns in the anterior pituitary gland of mouse, pig, and human by single-cell transcriptomics.J Neuroendocrinol202642633787PubTator, text miningPubMed
Sellar region neurocytomas exhibit a CIMP and neuroendocrine-like epigenetic signature distinct from other intra-axial neurocytomas.Acta Neuropathol202642611353PubTator, text miningPubMed

1 to 10 of 2,504

See all 2,504 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5449

GET https://conductscience.org/api/genes/v1/5449/patents?page=2