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ATR: ATR checkpoint kinase

1 protein, 53 patents, 4 drugs, 59 trials, 7,855 NIH grants and 17,885 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolATRHGNC
NameATR checkpoint kinaseHGNC
NCBI Gene ID545NCBI Gene
HGNC IDHGNC:882HGNC
EnsemblENSG00000175054NCBI Gene
AliasesFCTCS, FRP1, MEC1, SCKL, SCKL1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q13535Serine/threonine-protein kinase ATR2,64410Ensembl, GeneID, HGNCUniProt

Patents 53

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-296642Q13535Espacenet
JP 2025529142 A2025-09-04542Q13535Espacenet
US 12371689 B22025-07-29542Q13535Espacenet
JP 2025517969 A2025-06-126642Q13535Espacenet
JP 2025062604 A2025-04-147861Q13535Espacenet
JP 2024123008 A2024-09-104914Q13535Espacenet
US 11976334 B22024-05-07116Q13535Espacenet
JP 2024500874 A2024-01-1091Q13535Espacenet
US 11708396 B22023-07-252076Q13535Espacenet
JP 2022141755 A2022-09-29202Q13535Espacenet

Drugs 4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BERZOSERTIBCHEMBL3989870Serine-protein kinase ATR inhibitorINHIBITORChEMBL
CERALASERTIBCHEMBL4285417Serine-protein kinase ATR inhibitorINHIBITORChEMBL
ELIMUSERTIBCHEMBL4647810Serine-protein kinase ATR inhibitorINHIBITORChEMBL
M4344CHEMBL4650286Serine-protein kinase ATR inhibitorINHIBITORChEMBL

Trials 59

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06769126CERALASERTIBPHASE2ClinicalTrials.gov
NCT06732401CERALASERTIBPHASE3ClinicalTrials.gov
NCT06680050CERALASERTIBPHASE2ClinicalTrials.gov
NCT05582538CERALASERTIBPHASE2ClinicalTrials.gov
NCT05450692CERALASERTIBPHASE3ClinicalTrials.gov
NCT05071209ELIMUSERTIBPHASE1/PHASE22026-01-23ClinicalTrials.gov
NCT04826341BERZOSERTIBPHASE1/PHASE2ClinicalTrials.gov
NCT04807816BERZOSERTIBPHASE2ClinicalTrials.gov
NCT04802174BERZOSERTIBPHASE1/PHASE2ClinicalTrials.gov
NCT04768296BERZOSERTIBPHASE22024-09-26ClinicalTrials.gov

NIH grants 7855

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant2072,025NIH's project files
P30CA008748Cancer Center Support Grant1772,025NIH's project files
P01CA092584Structural Cell Biology of DNA Repair Machines872,025NIH's project files
P30CA047904Cancer Center Support Grant542,025NIH's project files
ZIABC006150DNA Repair, Cell Cycle Checkpoints and Apoptosis as Targets for Anticancer Drugs442,025NIH's project files
P30CA016086Cancer Center Support Grant422,025NIH's project files
P30ES010126UNC Center for Environmental Health and Susceptibility392,025NIH's project files
P30CA006973Regional Oncology Research Center362,025NIH's project files
P30CA016058Cancer Center Support Grant312,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program292,025NIH's project files

Papers 17885

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824309PubTator, text miningPubMed
42822211PubTator, text miningPubMed
42819173PubTator, text miningPubMed
42818383PubTator, text miningPubMed
42818220PubTator, text miningPubMed
42816529PubTator, text miningPubMed
42813003PubTator, text miningPubMed
42810418PubTator, text miningPubMed
42808417PubTator, text miningPubMed
42806713PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license