Gene · 5451
POU2F1: POU class 2 homeobox 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. POU2F1: POU class 2 homeobox 1. Genes, record 5451. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5451
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P14859 | POU domain, class 2, transcription factor 1 | 743 | 8 | Ensembl, GeneID, HGNC |
Source UniProt
Patents42
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026094314 A | 2026-06-09 | 53 | P14859 | Espacenet |
| JP 2026021360 A | 2026-02-10 | 144 | P14859 | Espacenet |
| JP 2026000906 A | 2026-01-06 | 241 | P14859 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 16166 | P14859 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 19682 | P14859 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 15503 | P14859 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 19682 | P14859 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 16166 | P14859 | Espacenet |
| JP 2025041709 A | 2025-03-26 | 71 | P14859 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 15503 | P14859 | Espacenet |
1 to 10 of 42
See all 42 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,324
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | POU2F1 papers | Newest fiscal year |
|---|---|---|---|
| P01CA013106 | Targeting Transcription and Splicing in Cancer | 27 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 19 | 2025 |
| P30CA014051 | Cancer Center Support (Core) Grant | 12 | 2025 |
| P30CA014520 | UW Comprehensive Cancer Center Support | 9 | 2025 |
| ZIAHD000056 | Neuropeptides and Carboxypeptidase E/ Neurotrophic Factor-alpha1 in Neural and Cognitive Functions | 8 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 7 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 6 | 2025 |
| P30CA014089 | University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG) | 6 | 2025 |
| P30CA042014 | Cancer Center Support Grant | 6 | 2025 |
| P30CA062203 | Cancer Center Support Grant | 5 | 2025 |
1 to 10 of 2,324Source NIH's project files
See all 2,324 nih grantsPapers3,509
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Metformin Pharmacogenetics in Heart Failure Patients with Reduced Ejection Fraction: Impact on Metformin and Growth Differentiation Factor-15 Plasma Levels. | Clin Pharmacokinet | 2026 | 42804152 | PubTator, text mining | PubMed |
| Berberine-Drug Interactions: Mechanisms, Clinical Relevance and Risk Stratification-A Narrative Review. | Pharmaceuticals (Basel) | 2026 | 42653808 | PubTator, text mining | PubMed |
| Correction to "POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation". | Adv Sci (Weinh) | 2026 | 42532019 | PubTator, text mining | PubMed |
| SHCBP1 promotes cisplatin resistance and progression of LSCC through POU2F1-mediated transcriptional activation. | Histol Histopathol | 2026 | 42473971 | PubTator, text mining | PubMed |
| ABHD11-AS1 Suppresses Colorectal Cancer Progression by Disrupting EIF4E-mediated POU2F1 Ubiquitination. | Int J Biol Sci | 2026 | 42157946 | PubTator, text mining | PubMed |
Targeted peptide-modified M2 exosomes drug delivery system for the targeted regulation of the lung injury microenvironment with isorhynchophylline (IRN): based on the inflammatory-metabolic-epigenetic synergy mechanism. | Br J Pharmacol | 2026 | 42134712 | PubTator, text mining | PubMed |
| EBNA1 inhibitors reveal CDC7 and POU2F1 as direct functional targets in EBV epithelial cancers. | mBio | 2026 | 42132380 | PubTator, text mining | PubMed |
| Quercetin-loaded cellulose nanocrystals for targeted redox modulation and inflammation control in rosacea therapy via the SOD2-NF-κB pathway. | Int J Biol Macromol | 2026 | 42106045 | PubTator, text mining | PubMed |
| Structural and functional analysis of OATP and ABCB1-mediated transport of pentamidine analogs: An integrated in vitro and in silico approach. | Eur J Pharm Sci | 2026 | 42009232 | PubTator, text mining | PubMed |
| Exosomal miR-199a-3p From Dermal Papilla Cells Regulates Hair Follicle Pigmentation by Targeting POU2F1 in Melanocytes. | FASEB J | 2026 | 41948944 | PubTator, text mining | PubMed |
1 to 10 of 3,509
See all 3,509 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5451
GET https://conductscience.org/api/genes/v1/5451/patents?page=2