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Gene · 5451

POU2F1: POU class 2 homeobox 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. POU2F1: POU class 2 homeobox 1. Genes, record 5451. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5451

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Gene

Symbol
POU2F1
HGNC
Name
POU class 2 homeobox 1
HGNC
NCBI Gene ID
5451
NCBI Gene
HGNC ID
HGNC:9212
HGNC
Ensembl
ENSG00000143190
NCBI Gene
Aliases
OCT1, OTF1, Oct1Z, oct-1B
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P14859POU domain, class 2, transcription factor 17438Ensembl, GeneID, HGNC

Source UniProt

Patents42

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026094314 A2026-06-0953P14859Espacenet
JP 2026021360 A2026-02-10144P14859Espacenet
JP 2026000906 A2026-01-06241P14859Espacenet
EP 4650780 A22025-11-1916166P14859Espacenet
EP 4641201 A22025-10-2919682P14859Espacenet
JP 2025147176 A2025-10-0615503P14859Espacenet
JP 2025517969 A2025-06-1219682P14859Espacenet
JP 2025517970 A2025-06-1216166P14859Espacenet
JP 2025041709 A2025-03-2671P14859Espacenet
JP 2025028160 A2025-02-2815503P14859Espacenet

1 to 10 of 42

See all 42 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,324

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePOU2F1 papersNewest fiscal year
P01CA013106Targeting Transcription and Splicing in Cancer272025
P30CA016672Cancer Center Support Grant192025
P30CA014051Cancer Center Support (Core) Grant122025
P30CA014520UW Comprehensive Cancer Center Support92025
ZIAHD000056Neuropeptides and Carboxypeptidase E/ Neurotrophic Factor-alpha1 in Neural and Cognitive Functions82025
P30CA016058Cancer Center Support Grant72025
P30CA008748Cancer Center Support Grant62025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)62025
P30CA042014Cancer Center Support Grant62025
P30CA062203Cancer Center Support Grant52025

1 to 10 of 2,324Source NIH's project files

See all 2,324 nih grants

Papers3,509

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Metformin Pharmacogenetics in Heart Failure Patients with Reduced Ejection Fraction: Impact on Metformin and Growth Differentiation Factor-15 Plasma Levels.Clin Pharmacokinet202642804152PubTator, text miningPubMed
Berberine-Drug Interactions: Mechanisms, Clinical Relevance and Risk Stratification-A Narrative Review.Pharmaceuticals (Basel)202642653808PubTator, text miningPubMed
Correction to "POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation".Adv Sci (Weinh)202642532019PubTator, text miningPubMed
SHCBP1 promotes cisplatin resistance and progression of LSCC through POU2F1-mediated transcriptional activation.Histol Histopathol202642473971PubTator, text miningPubMed
ABHD11-AS1 Suppresses Colorectal Cancer Progression by Disrupting EIF4E-mediated POU2F1 Ubiquitination.Int J Biol Sci202642157946PubTator, text miningPubMed
Targeted peptide-modified M2 exosomes drug delivery system for the targeted regulation of the lung injury microenvironment with isorhynchophylline (IRN): based on the inflammatory-metabolic-epigenetic synergy mechanism.
Br J Pharmacol202642134712PubTator, text miningPubMed
EBNA1 inhibitors reveal CDC7 and POU2F1 as direct functional targets in EBV epithelial cancers.mBio202642132380PubTator, text miningPubMed
Quercetin-loaded cellulose nanocrystals for targeted redox modulation and inflammation control in rosacea therapy via the SOD2-NF-κB pathway.Int J Biol Macromol202642106045PubTator, text miningPubMed
Structural and functional analysis of OATP and ABCB1-mediated transport of pentamidine analogs: An integrated in vitro and in silico approach.Eur J Pharm Sci202642009232PubTator, text miningPubMed
Exosomal miR-199a-3p From Dermal Papilla Cells Regulates Hair Follicle Pigmentation by Targeting POU2F1 in Melanocytes.FASEB J202641948944PubTator, text miningPubMed

1 to 10 of 3,509

See all 3,509 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

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GET https://conductscience.org/api/genes/v1/5451/patents?page=2