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Gene · 5454

POU3F2: POU class 3 homeobox 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. POU3F2: POU class 3 homeobox 2. Genes, record 5454. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5454

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Gene

Symbol
POU3F2
HGNC
Name
POU class 3 homeobox 2
HGNC
NCBI Gene ID
5454
NCBI Gene
HGNC ID
HGNC:9215
HGNC
Ensembl
ENSG00000184486
NCBI Gene
Aliases
BRN2, N-Oct3, OCT7, OTF-7, OTF7, POUF3, brn-2, oct-7
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P20265POU domain, class 3, transcription factor 24431Ensembl, GeneID, HGNC

Source UniProt

Patents51

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026048797 A2026-03-0534P20265Espacenet
JP 2026004568 A2026-01-1458840P20265Espacenet
EP 4641201 A22025-10-295496P20265Espacenet
JP 2025147176 A2025-10-0615507P20265Espacenet
JP 2025531671 A2025-09-2518P20265Espacenet
JP 2025530805 A2025-09-1729P20265Espacenet
EP 4573186 A12025-06-2518P20265Espacenet
JP 2025517969 A2025-06-125496P20265Espacenet
KR 1020250068664 A2025-05-1629P20265Espacenet
EP 4524243 A12025-03-195P20265Espacenet

1 to 10 of 51

See all 51 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,954

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePOU3F2 papersNewest fiscal year
P50CA097186The Pacific Northwest Prostate Cancer SPORE152025
P30CA008748Cancer Center Support Grant142025
R37CA241486Molecular mechanisms underlying lineage plasticity in prostate cancer82025
P01CA163227Androgen Receptor Action in Castration Resistant Prostate Cancer62025
P30CA016672Cancer Center Support Grant62025
R01CA097098Targeting the MUC1-C Oncoprotein in Triple-Negative Breast Cancer62025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202852025
P50CA186786Michigan Prostate SPORE 2025-203052025
P01CA163222Targetable epigenetic and transcriptional mechanisms in melanoma thatshape the microenvironment42025
P30CA030199Cancer Center Support Grant (CCSG)42025

1 to 10 of 1,954Source NIH's project files

See all 1,954 nih grants

Papers1,850

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
BRN2 in lineage plasticity: a prostate cancer-focused perspective.Endocrinology202642687120PubTator, text miningPubMed
The Marine Cembranoid Sarcophine Suppressed the Progression and Recurrence of the Metastatic Castration-Resistant Prostate Cancer via Downregulating EZH2-β-Catenin-Centered Oncogenic Network.Mar Drugs202642505963PubTator, text miningPubMed
Transcription Factors in the Pathogenesis of Schizophrenia.Life (Basel)202642195329PubTator, text miningPubMed
KCTD10 as a selective cancer dependency from transcription-replication conflicts (TRCs).Ageing Cancer Res Treat202642037670PubTator, text miningPubMed
Resistance to neoadjuvant talazoparib in triple-negative breast cancer by BRN2-induced ATR/STAT3 pathways or SHLD2 subclone expansion.Proc Natl Acad Sci U S A202641961819PubTator, text miningPubMed
Transposable element-mediated evolutionary expansion of Sox2- and Brn2-binding regulatory modules for mammalian neural-cell differentiation.Genome Biol202641952195PubTator, text miningPubMed
Reprogramming of neuronal genome function and phenotype by astrocytes.bioRxiv202641867870PubTator, text miningPubMed
DAB2IP: unifying cardiovascular pathogenesis and cardiovascular brain crosstalk.Front Cardiovasc Med202641798622PubTator, text miningPubMed
Pitfalls in analysis and interpretation of single-cell RNA-seq data in cancer.Neurooncol Adv202641769412PubTator, text miningPubMed
Reprogramming of astrocytes into motoneuron-like cells by a Ascl1-Myt1l-Pou3f2-Isl1 cocktail.Exp Cell Res202641763511PubTator, text miningPubMed

1 to 10 of 1,850

See all 1,850 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5454

GET https://conductscience.org/api/genes/v1/5454/patents?page=2