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DDIT4: DNA damage inducible transcript 4
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Gene · 54541

Papers3,069

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

1 to 20 of 3,069

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TitleJournalYearPMIDFound bySource
Nomilin Rewires mTOR-Driven Immunometabolism via DDIT4 to Restrain Psoriasis.Int J Biol Sci202642807832PubTator, text miningPubMed
Single-Cell Transcriptomic Profiling of Peripheral Blood in a Patient with Progressive Thyroid Eye Disease Following Total Thyroidectomy.Genes (Basel)202642793037PubTator, text miningPubMed
Integrative mRNA and miRNA Profiling Identifies Shared and Subtype-Associated PI3K-AKT-mTOR Pathway Dysregulation and Candidate miRNA-Mediated Regulatory Interactions in Endometriosis-Associated Ovarian Cancers (EAOCs).
Biomedicines202642792733PubTator, text miningPubMed
Bisphenol A exposure confers resistance to cisplatin in ovarian cancer via ERα-dependent DDIT4-mTOR-AKT signaling.J Hazard Mater202642767054PubTator, text miningPubMed
A HUWE1 regulatory helix gates ASCL1 degradation through its C-terminal phospho-degron in small cell lung cancer.Genes Dev202642722432PubTator, text miningPubMed
Enhancer-mediated DDIT4 activation by SMYD2-dependent H3K4me1 promotes pazopanib resistance in clear cell renal cell carcinoma.J Transl Med202642706534PubTator, text miningPubMed
ERN1 inhibition modifies hypoxic regulation of EGLN1 expression in U87MG glioblastoma cells.Endocr Regul202642672129PubTator, text miningPubMed
ATF4 activates a transcriptional program that chronically suppresses mTOR activity and promotes neurodegeneration in Parkinson disease models.Cell Rep202642599806PubTator, text miningPubMed
Yorkie/YAP Interactors: Fine-Tuning the Hippo Pathway Output.Cold Spring Harb Perspect Biol202642575696PubTator, text miningPubMed
Transcriptomic analysis reveals heart failure-related lncRNA LINC00670 as a regulator of colon cancer mesenchymal genes.Biochim Biophys Acta Mol Basis Dis202642526817PubTator, text miningPubMed
Exploring ferroptosis: Unraveling its potential role in autistic spectrum disorder.Neurosci Biobehav Rev202642521052PubTator, text miningPubMed
Molecular Pathogenesis and Therapeutic Response of Diffuse Large B Cell Lymphoma Genetic Subtypes.Annu Rev Cancer Biol202642487683PubTator, text miningPubMed
Weighted Single-Step Genomic Evaluation of Body Structural Traits for Early Selection of Growth Performance in Thai Swamp Buffalo.Animals (Basel)202642450718PubTator, text miningPubMed
NAT10 drives head and neck squamous cell carcinoma proliferation via ac4C modification of DDIT4 mRNA.Sci Rep202642410175PubTator, text miningPubMed
DDIT4 upregulation associates with gammadelta T Cells dysfunction in ART-suppressed people living with HIV-1.BMC Infect Dis202642399768PubTator, text miningPubMed
Repurposing loratadine to induce ferroptosis and overcome multidrug resistance: preclinical evidence in KB-V-1 cells.Front Oncol202642388634PubTator, text miningPubMed
Vitamin A-coupled MSCs- derived extracellular vesicles relieve acute liver injury by targeting hepatic stellate cells to deliver REDD1.J Nanobiotechnology202642310754PubTator, text miningPubMed
Critical illness expands a transcriptionally distinct hypometabolic CD8+ T effector program associated with respiratory failure and mortality.bioRxiv202642282739PubTator, text miningPubMed
A Mechanistic Model of the HIF-1/HIF-2 Switch Regulating Hypoxia-Induced Cancer Stemness.Int J Mol Sci202642278230PubTator, text miningPubMed
Acellular normothermic spleen perfusion resolves transcriptional and non-transcriptional mechanisms of steroid immunosuppression.bioRxiv202642239436PubTator, text miningPubMed

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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