ConductScience.org, home

Gene · 54541

DDIT4: DNA damage inducible transcript 4

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. DDIT4: DNA damage inducible transcript 4. Genes, record 54541. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/54541

On this page

Gene

Symbol
DDIT4
HGNC
Name
DNA damage inducible transcript 4
HGNC
NCBI Gene ID
54541
NCBI Gene
HGNC ID
HGNC:24944
HGNC
Ensembl
ENSG00000168209
NCBI Gene
Aliases
Dig2, FLJ20500, REDD-1, REDD1, RTP801
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NX09DNA damage-inducible transcript 4 protein2322Ensembl, GeneID, HGNC

Source UniProt

Patents107

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1444089Q9NX09Espacenet
EP 4667578 A22025-12-24206Q9NX09Espacenet
EP 4667578 A22025-12-24266Q9NX09Espacenet
EP 4650780 A22025-11-194495Q9NX09Espacenet
JP 2025131621 A2025-09-09206Q9NX09Espacenet
JP 2025131621 A2025-09-09266Q9NX09Espacenet
JP 2025517970 A2025-06-124495Q9NX09Espacenet
JP 2025032204 A2025-03-1127143Q9NX09Espacenet
EP 4461818 A22024-11-1327143Q9NX09Espacenet
US 11753639 B22023-09-1264Q9NX09Espacenet

1 to 10 of 107

See all 107 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,790

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDDIT4 papersNewest fiscal year
P30CA016672Cancer Center Support Grant142025
R01EY032879Redox-sensitive activation of REDD1 in diabetic retinopathy132025
P30CA008748Cancer Center Support Grant82025
R01DK105129MECHANISMS OF CHIEF CELL DEDIFFERENTIATION72025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center62025
P30DK052574Host-environment interactions in the pathophysiology of digestive disease62025
R01DK094989REGULATION OF ATROPHY-INDUCED PROGENITOR CELLS IN THE GASTRIC CORPUS62025
UL1TR001863Yale Clinical and Translational Science Award52025
P30AG024832UTMB Claude D. Pepper Older Americans Independence Center42025
P30CA006973Regional Oncology Research Center42025

1 to 10 of 1,790Source NIH's project files

See all 1,790 nih grants

Papers3,069

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Nomilin Rewires mTOR-Driven Immunometabolism via DDIT4 to Restrain Psoriasis.Int J Biol Sci202642807832PubTator, text miningPubMed
Single-Cell Transcriptomic Profiling of Peripheral Blood in a Patient with Progressive Thyroid Eye Disease Following Total Thyroidectomy.Genes (Basel)202642793037PubTator, text miningPubMed
Integrative mRNA and miRNA Profiling Identifies Shared and Subtype-Associated PI3K-AKT-mTOR Pathway Dysregulation and Candidate miRNA-Mediated Regulatory Interactions in Endometriosis-Associated Ovarian Cancers (EAOCs).
Biomedicines202642792733PubTator, text miningPubMed
Bisphenol A exposure confers resistance to cisplatin in ovarian cancer via ERα-dependent DDIT4-mTOR-AKT signaling.J Hazard Mater202642767054PubTator, text miningPubMed
A HUWE1 regulatory helix gates ASCL1 degradation through its C-terminal phospho-degron in small cell lung cancer.Genes Dev202642722432PubTator, text miningPubMed
Enhancer-mediated DDIT4 activation by SMYD2-dependent H3K4me1 promotes pazopanib resistance in clear cell renal cell carcinoma.J Transl Med202642706534PubTator, text miningPubMed
ERN1 inhibition modifies hypoxic regulation of EGLN1 expression in U87MG glioblastoma cells.Endocr Regul202642672129PubTator, text miningPubMed
ATF4 activates a transcriptional program that chronically suppresses mTOR activity and promotes neurodegeneration in Parkinson disease models.Cell Rep202642599806PubTator, text miningPubMed
Yorkie/YAP Interactors: Fine-Tuning the Hippo Pathway Output.Cold Spring Harb Perspect Biol202642575696PubTator, text miningPubMed
Transcriptomic analysis reveals heart failure-related lncRNA LINC00670 as a regulator of colon cancer mesenchymal genes.Biochim Biophys Acta Mol Basis Dis202642526817PubTator, text miningPubMed

1 to 10 of 3,069

See all 3,069 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/54541

GET https://conductscience.org/api/genes/v1/54541/patents?page=2