Gene · 54541
DDIT4: DNA damage inducible transcript 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. DDIT4: DNA damage inducible transcript 4. Genes, record 54541. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/54541
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9NX09 | DNA damage-inducible transcript 4 protein | 232 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents107
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 44089 | Q9NX09 | Espacenet |
| EP 4667578 A2 | 2025-12-24 | 206 | Q9NX09 | Espacenet |
| EP 4667578 A2 | 2025-12-24 | 266 | Q9NX09 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 4495 | Q9NX09 | Espacenet |
| JP 2025131621 A | 2025-09-09 | 206 | Q9NX09 | Espacenet |
| JP 2025131621 A | 2025-09-09 | 266 | Q9NX09 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 4495 | Q9NX09 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 27143 | Q9NX09 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 27143 | Q9NX09 | Espacenet |
| US 11753639 B2 | 2023-09-12 | 64 | Q9NX09 | Espacenet |
1 to 10 of 107
See all 107 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,790
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | DDIT4 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 14 | 2025 |
| R01EY032879 | Redox-sensitive activation of REDD1 in diabetic retinopathy | 13 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 8 | 2025 |
| R01DK105129 | MECHANISMS OF CHIEF CELL DEDIFFERENTIATION | 7 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 6 | 2025 |
| P30DK052574 | Host-environment interactions in the pathophysiology of digestive disease | 6 | 2025 |
| R01DK094989 | REGULATION OF ATROPHY-INDUCED PROGENITOR CELLS IN THE GASTRIC CORPUS | 6 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 5 | 2025 |
| P30AG024832 | UTMB Claude D. Pepper Older Americans Independence Center | 4 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 4 | 2025 |
1 to 10 of 1,790Source NIH's project files
See all 1,790 nih grantsPapers3,069
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Nomilin Rewires mTOR-Driven Immunometabolism via DDIT4 to Restrain Psoriasis. | Int J Biol Sci | 2026 | 42807832 | PubTator, text mining | PubMed |
| Single-Cell Transcriptomic Profiling of Peripheral Blood in a Patient with Progressive Thyroid Eye Disease Following Total Thyroidectomy. | Genes (Basel) | 2026 | 42793037 | PubTator, text mining | PubMed |
Integrative mRNA and miRNA Profiling Identifies Shared and Subtype-Associated PI3K-AKT-mTOR Pathway Dysregulation and Candidate miRNA-Mediated Regulatory Interactions in Endometriosis-Associated Ovarian Cancers (EAOCs). | Biomedicines | 2026 | 42792733 | PubTator, text mining | PubMed |
| Bisphenol A exposure confers resistance to cisplatin in ovarian cancer via ERα-dependent DDIT4-mTOR-AKT signaling. | J Hazard Mater | 2026 | 42767054 | PubTator, text mining | PubMed |
| A HUWE1 regulatory helix gates ASCL1 degradation through its C-terminal phospho-degron in small cell lung cancer. | Genes Dev | 2026 | 42722432 | PubTator, text mining | PubMed |
| Enhancer-mediated DDIT4 activation by SMYD2-dependent H3K4me1 promotes pazopanib resistance in clear cell renal cell carcinoma. | J Transl Med | 2026 | 42706534 | PubTator, text mining | PubMed |
| ERN1 inhibition modifies hypoxic regulation of EGLN1 expression in U87MG glioblastoma cells. | Endocr Regul | 2026 | 42672129 | PubTator, text mining | PubMed |
| ATF4 activates a transcriptional program that chronically suppresses mTOR activity and promotes neurodegeneration in Parkinson disease models. | Cell Rep | 2026 | 42599806 | PubTator, text mining | PubMed |
| Yorkie/YAP Interactors: Fine-Tuning the Hippo Pathway Output. | Cold Spring Harb Perspect Biol | 2026 | 42575696 | PubTator, text mining | PubMed |
| Transcriptomic analysis reveals heart failure-related lncRNA LINC00670 as a regulator of colon cancer mesenchymal genes. | Biochim Biophys Acta Mol Basis Dis | 2026 | 42526817 | PubTator, text mining | PubMed |
1 to 10 of 3,069
See all 3,069 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/54541
GET https://conductscience.org/api/genes/v1/54541/patents?page=2