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Gene · 54567

DLL4: delta like canonical Notch ligand 4

11 sourcesgene-search-2026-11-11-0.1.0

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ConductScience Library. DLL4: delta like canonical Notch ligand 4. Genes, record 54567. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/54567

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Gene

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

Symbol
DLL4
HGNC
Name
delta like canonical Notch ligand 4
HGNC
NCBI Gene ID
54567
NCBI Gene
HGNC ID
HGNC:2910
HGNC
Ensembl
ENSG00000128917
NCBI Gene
Aliases
AOS6, delta4, hdelta2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NR61Delta-like protein 46851Ensembl, GeneID, HGNC

Source UniProt

Patents425

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4830720 A12026-10-286Q9NR61Espacenet
EP 4756030 A12026-06-1022Q9NR61Espacenet
EP 4728053 A12026-04-221Q9NR61Espacenet
EP 4728054 A12026-04-221Q9NR61Espacenet
JP 2026508154 A2026-03-106Q9NR61Espacenet
US 12570741 B22026-03-1022Q9NR61Espacenet
JP 2026507050 A2026-02-272Q9NR61Espacenet
JP 2026004568 A2026-01-1443565Q9NR61Espacenet
EP 4655390 A12025-12-031Q9NR61Espacenet
EP 4650780 A22025-11-191283Q9NR61Espacenet

1 to 10 of 425

See all 425 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DEMCIZUMABCHEMBL2109384Delta-like protein 4 inhibitorINHIBITORChEMBL
ENOTICUMABCHEMBL2109385Delta-like protein 4 inhibitorINHIBITORChEMBL
MEDI-639CHEMBL2109382Delta-like protein 4 binding agentBINDING AGENTChEMBL

Trials6

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02289898DEMCIZUMABPHASE22018-08-08ClinicalTrials.gov
NCT02259582DEMCIZUMABPHASE22018-08-20ClinicalTrials.gov
NCT01952249DEMCIZUMABPHASE1ClinicalTrials.gov
NCT01189968DEMCIZUMABPHASE1ClinicalTrials.gov
NCT01189942DEMCIZUMABPHASE1ClinicalTrials.gov
NCT01189929DEMCIZUMABPHASE1ClinicalTrials.gov

NIH grants2,720

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal year
P30CA016672Cancer Center Support Grant282025
P30CA008748Cancer Center Support Grant182025
R01AI091627Notch Signaling in Alloimmunity132025
P30CA016042Cancer Center Support Grant102025
P51OD011106Wisconsin National Primate Research Center Support92025
R01HL112626Notch in Angiogenesis and Vascular Biology82025
P30CA046934University of Colorado Cancer Center Support Grant72025
UL1TR001863Yale Clinical and Translational Science Award72025
P30CA013330Cancer Center Support Grant62025
U54CA1186381/3 Morehouse School of Medicine/Tuskegee University/University of Alabama at Birmingham O'Neal Comprehensive Cancer Center Partnership62025

1 to 10 of 2,720Source NIH's project files

See all 2,720 nih grants

Papers4,267

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42770619PubTator, text miningPubMed
42765743PubTator, text miningPubMed
42762147PubTator, text miningPubMed
42732006PubTator, text miningPubMed
42726640PubTator, text miningPubMed
42676697PubTator, text miningPubMed
42619610PubTator, text miningPubMed
42559487PubTator, text miningPubMed
42479463PubTator, text miningPubMed
42477815PubTator, text miningPubMed

1 to 10 of 4,267

See all 4,267 papers

Sources 11

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNone stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GeneNone named. Public domain as US government information
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/54567

GET https://conductscience.org/api/genes/v1/54567/patents?page=2