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Gene · 54623

PAF1: PAF1 component of Paf1/RNA polymerase II complex

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PAF1: PAF1 component of Paf1/RNA polymerase II complex. Genes, record 54623. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/54623

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Gene

Symbol
PAF1
HGNC
Name
PAF1 component of Paf1/RNA polymerase II complex
HGNC
NCBI Gene ID
54623
NCBI Gene
HGNC ID
HGNC:25459
HGNC
Ensembl
ENSG00000006712
NCBI Gene
Aliases
F23149_1, FLJ11123, PD2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8N7H5RNA polymerase II-associated factor 1 homolog53121Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-19502Q8N7H5Espacenet
JP 2025517970 A2025-06-12502Q8N7H5Espacenet
JP 2024123008 A2024-09-107513Q8N7H5Espacenet
US 11446398 B22022-09-2060859Q8N7H5Espacenet
JP 2022524081 A2022-04-27163830Q8N7H5Espacenet
US 10501513 B22019-12-107513Q8N7H5Espacenet
JP 2017197545 A2017-11-0232214Q8N7H5Espacenet
JP 2017171657 A2017-09-2866Q8N7H5Espacenet
US 9587003 B22017-03-077513Q8N7H5Espacenet
US 9301993 B22016-04-057513Q8N7H5Espacenet

1 to 10 of 26

See all 26 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,119

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePAF1 papersNewest fiscal year
P30CA021765Cancer Center Support Grant (CCSG)192025
P30CA008748Cancer Center Support Grant132025
U01CA210240Pancreatic Cancer Detection Consortium82025
P30AI027763UCSF-Bay Area Center for AIDS Research72025
U01CA200466Validation of biomarkers for risk prediction and early diagnosis of Pancreatic Adenocarcinoma72025
P30CA016058Cancer Center Support Grant52025
P30CA016087Cancer Center Support Grant42025
P30CA046934University of Colorado Cancer Center Support Grant42025
ZIADK043012Clinical Investigation of FIHP, Parathyroid Cancer & the HPT-JT Syndrome42025
P30CA036727Buffett Cancer Center Support Grant32025

1 to 10 of 1,119Source NIH's project files

See all 1,119 nih grants

Papers1,656

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
PAF1 integrates conserved and plant-specific mechanisms in response to DNA replication stress.Nat Plants202642637854PubTator, text miningPubMed
Molecular and immune correlates of lymphocyte activation gene-3 expression in renal cell carcinoma.Oncologist202642578740PubTator, text miningPubMed
The HIV-1 restriction factor RPRD2 does not inhibit transcription of HIV-1 or endogenous retroelements.bioRxiv202642539190PubTator, text miningPubMed
Deep learning-based CD8+ T cell model for predicting prognosis and‌ targeted immunotherapy benefit in ccRCC.NPJ Digit Med202642443348PubTator, text miningPubMed
PAF1c depletion confers chemoresistance to topoisomerase inhibitors.Cell Insight202642325246PubTator, text miningPubMed
Evolutionary acquisition of an interaction between conserved proteins drives plant-specific cell cycle progression.Nat Commun202642209502PubTator, text miningPubMed
Stress granule assembly represents a therapeutic vulnerability in super-enhancer-driven circMLB-mediated glioblastoma temozolomide resistance.Cancer Lett202642167397PubTator, text miningPubMed
Unraveling the layers of epigenetic control in respiratory antiviral defense.J Virol202642159289PubTator, text miningPubMed
A Multivalent Supramolecular Assembly for the Detection and Removal of Pd2.Inorg Chem202642095578PubTator, text miningPubMed
Palladium(II) Complexes with Chloro-Substituted Salicyl Schiff Bases: Exploring Multimodal Anticancer Mechanisms and Catalase Inhibition.Molecules202642076047PubTator, text miningPubMed

1 to 10 of 1,656

See all 1,656 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/54623

GET https://conductscience.org/api/genes/v1/54623/patents?page=2