Gene · 54623
PAF1: PAF1 component of Paf1/RNA polymerase II complex
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PAF1: PAF1 component of Paf1/RNA polymerase II complex. Genes, record 54623. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/54623
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q8N7H5 | RNA polymerase II-associated factor 1 homolog | 531 | 21 | Ensembl, GeneID, HGNC |
Source UniProt
Patents26
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 502 | Q8N7H5 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 502 | Q8N7H5 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 7513 | Q8N7H5 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 60859 | Q8N7H5 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 163830 | Q8N7H5 | Espacenet |
| US 10501513 B2 | 2019-12-10 | 7513 | Q8N7H5 | Espacenet |
| JP 2017197545 A | 2017-11-02 | 32214 | Q8N7H5 | Espacenet |
| JP 2017171657 A | 2017-09-28 | 66 | Q8N7H5 | Espacenet |
| US 9587003 B2 | 2017-03-07 | 7513 | Q8N7H5 | Espacenet |
| US 9301993 B2 | 2016-04-05 | 7513 | Q8N7H5 | Espacenet |
1 to 10 of 26
See all 26 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,119
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PAF1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA021765 | Cancer Center Support Grant (CCSG) | 19 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 13 | 2025 |
| U01CA210240 | Pancreatic Cancer Detection Consortium | 8 | 2025 |
| P30AI027763 | UCSF-Bay Area Center for AIDS Research | 7 | 2025 |
| U01CA200466 | Validation of biomarkers for risk prediction and early diagnosis of Pancreatic Adenocarcinoma | 7 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 5 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 4 | 2025 |
| P30CA046934 | University of Colorado Cancer Center Support Grant | 4 | 2025 |
| ZIADK043012 | Clinical Investigation of FIHP, Parathyroid Cancer & the HPT-JT Syndrome | 4 | 2025 |
| P30CA036727 | Buffett Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,119Source NIH's project files
See all 1,119 nih grantsPapers1,656
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| PAF1 integrates conserved and plant-specific mechanisms in response to DNA replication stress. | Nat Plants | 2026 | 42637854 | PubTator, text mining | PubMed |
| Molecular and immune correlates of lymphocyte activation gene-3 expression in renal cell carcinoma. | Oncologist | 2026 | 42578740 | PubTator, text mining | PubMed |
| The HIV-1 restriction factor RPRD2 does not inhibit transcription of HIV-1 or endogenous retroelements. | bioRxiv | 2026 | 42539190 | PubTator, text mining | PubMed |
| Deep learning-based CD8+ T cell model for predicting prognosis and targeted immunotherapy benefit in ccRCC. | NPJ Digit Med | 2026 | 42443348 | PubTator, text mining | PubMed |
| PAF1c depletion confers chemoresistance to topoisomerase inhibitors. | Cell Insight | 2026 | 42325246 | PubTator, text mining | PubMed |
| Evolutionary acquisition of an interaction between conserved proteins drives plant-specific cell cycle progression. | Nat Commun | 2026 | 42209502 | PubTator, text mining | PubMed |
| Stress granule assembly represents a therapeutic vulnerability in super-enhancer-driven circMLB-mediated glioblastoma temozolomide resistance. | Cancer Lett | 2026 | 42167397 | PubTator, text mining | PubMed |
| Unraveling the layers of epigenetic control in respiratory antiviral defense. | J Virol | 2026 | 42159289 | PubTator, text mining | PubMed |
| A Multivalent Supramolecular Assembly for the Detection and Removal of Pd2. | Inorg Chem | 2026 | 42095578 | PubTator, text mining | PubMed |
| Palladium(II) Complexes with Chloro-Substituted Salicyl Schiff Bases: Exploring Multimodal Anticancer Mechanisms and Catalase Inhibition. | Molecules | 2026 | 42076047 | PubTator, text mining | PubMed |
1 to 10 of 1,656
See all 1,656 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/54623
GET https://conductscience.org/api/genes/v1/54623/patents?page=2