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Gene · 5464

PPA1: inorganic pyrophosphatase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PPA1: inorganic pyrophosphatase 1. Genes, record 5464. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5464

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Gene

Symbol
PPA1
HGNC
Name
inorganic pyrophosphatase 1
HGNC
NCBI Gene ID
5464
NCBI Gene
HGNC ID
HGNC:9226
HGNC
Ensembl
ENSG00000180817
NCBI Gene
Aliases
HEL-S-66p, IOPPP, PP, PP1, Ppase, SID6-8061
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q15181Inorganic pyrophosphatase2894Ensembl, GeneID, HGNC

Source UniProt

Patents56

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-199276Q15181Espacenet
EP 4641202 A22025-10-295577Q15181Espacenet
JP 2025517970 A2025-06-129276Q15181Espacenet
US 12285484 B22025-04-29315Q15181Espacenet
KR 1020250017231 A2025-02-045577Q15181Espacenet
US 11564998 B22023-01-316347Q15181Espacenet
US 11446398 B22022-09-2070246Q15181Espacenet
JP 2022524081 A2022-04-27173217Q15181Espacenet
JP 2022502079 A2022-01-11319Q15181Espacenet
US 11078247 B22021-08-038775Q15181Espacenet

1 to 10 of 56

See all 56 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,967

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePPA1 papersNewest fiscal year
P30AI117970District of Columbia Center for AIDS Research72025
P30CA008748Cancer Center Support Grant72025
R35GM119455Mechanisms of Phosphorylation Signaling by Phosphoprotein Phosphatases62025
ZIADE000735Ca2+ signaling and HCO3- secretion by exocrine glands52025
P30CA016672Cancer Center Support Grant42025
P30CA036727Buffett Cancer Center Support Grant42025
P30CA076292Moffitt Cancer Center Support Grant42025
U54MD007597Howard University Research Center for Minority Health and Health Disparities42025
P30CA006973Regional Oncology Research Center32025
P30CA016086Cancer Center Support Grant32025

1 to 10 of 1,967Source NIH's project files

See all 1,967 nih grants

Papers3,642

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Nsp3 Ubl1-orchestrated dephosphorylation of N protein promotes coronaviral subgenomic RNA synthesis.bioRxiv202642818347PubTator, text miningPubMed
SCRIB inhibits PP1 phosphatase activity without blocking or structurally altering its active site.J Biol Chem202642778107PubTator, text miningPubMed
A recurrent CCDC82 frameshift variant associated with syndromic neurodevelopmental disorder in a consanguineous Pakistani family.Biochem Biophys Rep202642732216PubTator, text miningPubMed
Molecular-weight fractionation, preliminary structural characterization, bioactivity, and ICP-MS-based biodistribution of Grifola frondosa polysaccharide-derived fractions.Front Nutr202642724102PubTator, text miningPubMed
[Effect of inorganic pyrophosphatase PPA1 on proliferation and apoptosis of abnormal naive cells in acute B-lymphocytic leukemia].Zhonghua Xue Ye Xue Za Zhi202642706173PubTator, text miningPubMed
Nuclear-targeted GDOWN1 potently suppresses tumors by inducing premature transcription termination and exporting Pol Ⅱ CTD phosphatases to activate RB.Cell Death Differ202642649379PubTator, text miningPubMed
Cardiotropic adeno-associated virus-based gene therapy via intracoronary delivery for nonischemic heart failure.Can J Physiol Pharmacol202642617187PubTator, text miningPubMed
Optimization of a malachite green-pyrophosphatase assay for the Zika virus RNA-dependent RNA polymerase and preliminary identification of natural product modulators.Front Drug Discov (Lausanne)202642577774PubTator, text miningPubMed
E3 ligase RNF145 regulates airway smooth muscle cell proliferation via the PP2A-p70S6K signaling axis.J Biol Chem202642575436PubTator, text miningPubMed
Erratum to "Targeting the ANXA8-SP1-PPA1 Axis to Modulate TCA Cycle and Matrix Deposition in Diffuse-Type Gastric Cancer".Research (Wash D C)202642558914PubTator, text miningPubMed

1 to 10 of 3,642

See all 3,642 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5464

GET https://conductscience.org/api/genes/v1/5464/patents?page=2