Gene · 5464
PPA1: inorganic pyrophosphatase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PPA1: inorganic pyrophosphatase 1. Genes, record 5464. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5464
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q15181 | Inorganic pyrophosphatase | 289 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents56
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 9276 | Q15181 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 5577 | Q15181 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 9276 | Q15181 | Espacenet |
| US 12285484 B2 | 2025-04-29 | 315 | Q15181 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 5577 | Q15181 | Espacenet |
| US 11564998 B2 | 2023-01-31 | 6347 | Q15181 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 70246 | Q15181 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 173217 | Q15181 | Espacenet |
| JP 2022502079 A | 2022-01-11 | 319 | Q15181 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 8775 | Q15181 | Espacenet |
1 to 10 of 56
See all 56 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,967
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PPA1 papers | Newest fiscal year |
|---|---|---|---|
| P30AI117970 | District of Columbia Center for AIDS Research | 7 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 7 | 2025 |
| R35GM119455 | Mechanisms of Phosphorylation Signaling by Phosphoprotein Phosphatases | 6 | 2025 |
| ZIADE000735 | Ca2+ signaling and HCO3- secretion by exocrine glands | 5 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| P30CA036727 | Buffett Cancer Center Support Grant | 4 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 4 | 2025 |
| U54MD007597 | Howard University Research Center for Minority Health and Health Disparities | 4 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 3 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,967Source NIH's project files
See all 1,967 nih grantsPapers3,642
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Nsp3 Ubl1-orchestrated dephosphorylation of N protein promotes coronaviral subgenomic RNA synthesis. | bioRxiv | 2026 | 42818347 | PubTator, text mining | PubMed |
| SCRIB inhibits PP1 phosphatase activity without blocking or structurally altering its active site. | J Biol Chem | 2026 | 42778107 | PubTator, text mining | PubMed |
| A recurrent CCDC82 frameshift variant associated with syndromic neurodevelopmental disorder in a consanguineous Pakistani family. | Biochem Biophys Rep | 2026 | 42732216 | PubTator, text mining | PubMed |
| Molecular-weight fractionation, preliminary structural characterization, bioactivity, and ICP-MS-based biodistribution of Grifola frondosa polysaccharide-derived fractions. | Front Nutr | 2026 | 42724102 | PubTator, text mining | PubMed |
| [Effect of inorganic pyrophosphatase PPA1 on proliferation and apoptosis of abnormal naive cells in acute B-lymphocytic leukemia]. | Zhonghua Xue Ye Xue Za Zhi | 2026 | 42706173 | PubTator, text mining | PubMed |
| Nuclear-targeted GDOWN1 potently suppresses tumors by inducing premature transcription termination and exporting Pol Ⅱ CTD phosphatases to activate RB. | Cell Death Differ | 2026 | 42649379 | PubTator, text mining | PubMed |
| Cardiotropic adeno-associated virus-based gene therapy via intracoronary delivery for nonischemic heart failure. | Can J Physiol Pharmacol | 2026 | 42617187 | PubTator, text mining | PubMed |
| Optimization of a malachite green-pyrophosphatase assay for the Zika virus RNA-dependent RNA polymerase and preliminary identification of natural product modulators. | Front Drug Discov (Lausanne) | 2026 | 42577774 | PubTator, text mining | PubMed |
| E3 ligase RNF145 regulates airway smooth muscle cell proliferation via the PP2A-p70S6K signaling axis. | J Biol Chem | 2026 | 42575436 | PubTator, text mining | PubMed |
| Erratum to "Targeting the ANXA8-SP1-PPA1 Axis to Modulate TCA Cycle and Matrix Deposition in Diffuse-Type Gastric Cancer". | Research (Wash D C) | 2026 | 42558914 | PubTator, text mining | PubMed |
1 to 10 of 3,642
See all 3,642 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5464
GET https://conductscience.org/api/genes/v1/5464/patents?page=2