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PPARA: peroxisome proliferator activated receptor alpha

1 protein, 89 patents, 27 drugs, 262 trials, 11,310 NIH grants and 34,033 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPPARAHGNC
Nameperoxisome proliferator activated receptor alphaHGNC
NCBI Gene ID5465NCBI Gene
HGNC IDHGNC:9232HGNC
EnsemblENSG00000186951NCBI Gene
AliasesNR1C1, PPAR, PPAR-alpha, PPARalpha, hPPARNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q07869Peroxisome proliferator-activated receptor alpha46879Ensembl, GeneID, HGNCUniProt

Patents 89

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026086503 A2026-05-2680Q07869Espacenet
JP 2026004568 A2026-01-1457450Q07869Espacenet
JP 2026004568 A2026-01-1457451Q07869Espacenet
JP 2026004568 A2026-01-1457452Q07869Espacenet
JP 2026004568 A2026-01-1457453Q07869Espacenet
JP 2025147176 A2025-10-0615518Q07869Espacenet
EP 4516308 A22025-03-0580Q07869Espacenet
JP 2025028160 A2025-02-2815518Q07869Espacenet
KR 1020250010750 A2025-01-2115518Q07869Espacenet
WO 2024204454 A2024-10-034Q07869Espacenet

Drugs 27

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALEGLITAZARCHEMBL519504Peroxisome proliferator-activated receptor alpha agonistAGONISTChEMBL
AVE8134CHEMBL3545334Peroxisome proliferator-activated receptor alpha agonistAGONISTChEMBL
BEZAFIBRATECHEMBL264374Peroxisome proliferator-activated receptor agonistAGONISTChEMBL
CHIGLITAZARCHEMBL4650349Peroxisome proliferator-activated receptor agonistAGONISTChEMBL
CHOLINE FENOFIBRATECHEMBL1201745Peroxisome proliferator-activated receptor alpha agonistAGONISTChEMBL
CIPROFIBRATECHEMBL557555Peroxisome proliferator-activated receptor alpha agonistAGONISTChEMBL
CLOFIBRATECHEMBL565Peroxisome proliferator-activated receptor alpha agonistAGONISTChEMBL
CP-778875CHEMBL5314385Peroxisome proliferator-activated receptor alpha agonistAGONISTChEMBL
DRF-10945CHEMBL3545394Peroxisome proliferator-activated receptor alpha agonistAGONISTChEMBL
ELAFIBRANORCHEMBL3707395Peroxisome proliferator-activated receptor alpha agonistAGONISTChEMBL

Trials 262

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07580638CHIGLITAZARClinicalTrials.gov
NCT07572552FENOFIBRATEPHASE2ClinicalTrials.gov
NCT07424677SAROGLITAZARPHASE3ClinicalTrials.gov
NCT07387549ELAFIBRANORPHASE3ClinicalTrials.gov
NCT07303803CHIGLITAZARPHASE2ClinicalTrials.gov
NCT07296458FENOFIBRATEPHASE3ClinicalTrials.gov
NCT07216235SAROGLITAZARPHASE3ClinicalTrials.gov
NCT07104201FENOFIBRATEEARLY_PHASE1ClinicalTrials.gov
NCT06825559SAROGLITAZARPHASE1ClinicalTrials.gov
NCT06773221CHIGLITAZARClinicalTrials.gov

NIH grants 11310

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
ZIABC005708Xenobiotic metabolism, cancer chemoprevention and cancer biomarkers972,025NIH's project files
ZIABC005562Xenobiotic receptors922,025NIH's project files
P30DK056341Washington University Nutrition Obesity Research Center782,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)622,025NIH's project files
P30DK020579Diabetes Research Center402,025NIH's project files
P30CA016672Cancer Center Support Grant382,025NIH's project files
P30ES017885Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)372,025NIH's project files
P30DK052574Host-environment interactions in the pathophysiology of digestive disease312,025NIH's project files
P30ES010126UNC Center for Environmental Health and Susceptibility282,025NIH's project files
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)262,025NIH's project files

Papers 34033

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42823563PubTator, text miningPubMed
42817135PubTator, text miningPubMed
42815761PubTator, text miningPubMed
42815117PubTator, text miningPubMed
42814802PubTator, text miningPubMed
42809160PubTator, text miningPubMed
42806046PubTator, text miningPubMed
42802602PubTator, text miningPubMed
42802156PubTator, text miningPubMed
42800922PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license