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Gene · 54681

P4HTM: prolyl 4-hydroxylase, transmembrane

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. P4HTM: prolyl 4-hydroxylase, transmembrane. Genes, record 54681. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/54681

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Gene

Symbol
P4HTM
HGNC
Name
prolyl 4-hydroxylase, transmembrane
HGNC
NCBI Gene ID
54681
NCBI Gene
HGNC ID
HGNC:28858
HGNC
Ensembl
ENSG00000178467
NCBI Gene
Aliases
EGLN4, FLJ20262, HIDEA, HIFPH4, P4H-TM, PH-4, PH4, PHD4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NXG6Transmembrane prolyl 4-hydroxylase5021Ensembl, GeneID, HGNC

Source UniProt

Patents12

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1910612Q9NXG6Espacenet
EP 4641201 A22025-10-2910992Q9NXG6Espacenet
JP 2025529142 A2025-09-043329Q9NXG6Espacenet
US 12371689 B22025-07-293329Q9NXG6Espacenet
JP 2025517969 A2025-06-1210992Q9NXG6Espacenet
JP 2025517970 A2025-06-1210612Q9NXG6Espacenet
US 11446398 B22022-09-2067294Q9NXG6Espacenet
US 11400116 B22022-08-026504Q9NXG6Espacenet
JP 2022524081 A2022-04-27170265Q9NXG6Espacenet
JP 2017121240 A2017-07-1353172Q9NXG6Espacenet

1 to 10 of 12

See all 12 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DAPRODUSTATCHEMBL3544988Hypoxia-inducible factor prolyl hydroxylase inhibitorINHIBITORChEMBL
ROXADUSTATCHEMBL2338329Hypoxia-inducible factor prolyl hydroxylase inhibitorINHIBITORChEMBL

Trials76

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07359027ROXADUSTATPHASE4ClinicalTrials.gov
NCT07346547DAPRODUSTATClinicalTrials.gov
NCT07300111DAPRODUSTATPHASE3ClinicalTrials.gov
NCT07268807ROXADUSTATClinicalTrials.gov
NCT07136792ROXADUSTATClinicalTrials.gov
NCT07045155ROXADUSTATPHASE4ClinicalTrials.gov
NCT06917950ROXADUSTATPHASE1/PHASE2ClinicalTrials.gov
NCT06903559ROXADUSTATPHASE1/PHASE2ClinicalTrials.gov
NCT06772272ROXADUSTATPHASE3ClinicalTrials.gov
NCT06115421ROXADUSTATPHASE4ClinicalTrials.gov

1 to 10 of 76

See all 76 trials

NIH grants240

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleP4HTM papersNewest fiscal year
K01AA030083Mass Multivariate Derivation and Validation of AUD Biotypes using Developmental Imaging and Genomic Approaches32025
DP1DA054394Building Bridges to Allow Cross-species Translational genetics for the Study of Addiction22025
K01DA051759Identifying genetic sources of comorbidity between cannabis and schizophrenia using genome-wide and integrative omics data22025
P50AA022537Cross-species investigation of gene networks for ethanol-related behaviors22025
R01DA0548697/7 Psychiatric Genomics Consortium: Advancing Discovery and Impact22025
I01BX002348Cellular and Molecular Mechanisms of Renal Anemia12025
I01BX004820Genetic Vulnerability for Sustained Multi-Substance Use in MVP12025
K12EY022299Michigan Vision Clinician Scientist Development Program12025
P2CHD042849Population Research Center12025
P30AG066614Center on Aging and Population Sciences12025

1 to 10 of 240Source NIH's project files

See all 240 nih grants

Papers302

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Identification of Potential Therapeutic Targets and Drugs for Depression: A Genome-Wide Druggable Mendelian Randomization and Molecular Docking Study.Curr Med Chem202642576535PubTator, text miningPubMed
ChSCL9 negatively regulates citric acid accumulation via repressing PH4-PH5 module in kumquat.Plant Physiol202642378656PubTator, text miningPubMed
Convergent molecular signatures across eating disorders and obsessive-compulsive disorder in the human brain.Cell Rep202642295976PubTator, text miningPubMed
Research advances in biosynthesis of trans-4-hydroxy-L-proline.J Biotechnol202641911954PubTator, text miningPubMed
Molecular determinants of allosteric modulation of protein disulfide isomerase by small-molecule b'-ligands.Redox Biol202641610518PubTator, text miningPubMed
Vibrational spectra of the radiation-induced cationic species resulting from phosphine monomers and dimers: A matrix isolation and CCSD(T) study.J Chem Phys202641492990PubTator, text miningPubMed
Advances in the genetics of refractive errors: Contributions from the CREAM consortium.Acta Ophthalmol202641230783PubTator, text miningPubMed
In Silico Optimization of Inhibitors of the 3-Chymotrypsin-like Protease of SARS-CoV-2.Life (Basel)202541598161PubTator, text miningPubMed
Exploration into the MLL4/WRAD Enzyme-Substrate Network: Systematic In Vitro Identification of CFP1 as a Potential Non-Histone Substrate of the MLL4 Lysine Methyltransferase.Epigenomes202541133716PubTator, text miningPubMed
Integrated Approach of Machine Learning and High-Throughput Screening to Identify Chemical Probe Candidates Targeting Aldehyde Dehydrogenases.ACS Pharmacol Transl Sci202541098570PubTator, text miningPubMed

1 to 10 of 302

See all 302 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/54681

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