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Gene · 5469

MED1: mediator complex subunit 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MED1: mediator complex subunit 1. Genes, record 5469. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5469

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Gene

Symbol
MED1
HGNC
Name
mediator complex subunit 1
HGNC
NCBI Gene ID
5469
NCBI Gene
HGNC ID
HGNC:9234
HGNC
Ensembl
ENSG00000125686
NCBI Gene
Aliases
CRSP1, CRSP200, DRIP205, DRIP230, PBP, PPARBP, PPARGBP, RB18A, TRAP220, TRIP2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q15648Mediator of RNA polymerase II transcription subunit 11,58184Ensembl, GeneID, HGNC

Source UniProt

Patents21

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1452797Q15648Espacenet
EP 4641201 A22025-10-293595Q15648Espacenet
JP 2025517969 A2025-06-123595Q15648Espacenet
EP 4366774 A22024-05-15138Q15648Espacenet
US 11446398 B22022-09-2049673Q15648Espacenet
JP 2022524081 A2022-04-27152644Q15648Espacenet
KR 1020210129616 A2021-10-2812Q15648Espacenet
KR 1020210128370 A2021-10-2626Q15648Espacenet
KR 1020210125457 A2021-10-185Q15648Espacenet
US 11136562 B22021-10-05286Q15648Espacenet

1 to 10 of 21

See all 21 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,172

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMED1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant152025
P30CA008748Cancer Center Support Grant102025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center102025
P30CA006927Comprehensive Cancer Center Program at Fox Chase82025
P01CA163227Androgen Receptor Action in Castration Resistant Prostate Cancer72025
P30CA014051Cancer Center Support (Core) Grant72025
R01DK018477Enhancer Connectomes in Regulation of Gene Expression72025
P30CA016056Roswell Park Cancer Center Support Grant62025
P30CA016058Cancer Center Support Grant62025
P30CA046934University of Colorado Cancer Center Support Grant62025

1 to 10 of 2,172Source NIH's project files

See all 2,172 nih grants

Papers2,516

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Mediator at the Helm: Coordinating transcription and biomolecular condensates in hematopoiesis.Curr Top Dev Biol202642754322PubTator, text miningPubMed
Hepatic MED1 disruption ameliorates obesity-related fatty liver by attenuating SREBP1-driven lipogenesis.Metabolism202642660222PubTator, text miningPubMed
FOSL1-mediated super-enhancer facilitates pathological scarring.Cell Rep202642418324PubTator, text miningPubMed
The Role of the Mediator Complex in Modulating CjXDR1-Induced Multidrug Resistance and Virulence in Clarireedia jacksonii.Phytopathology202642308477PubTator, text miningPubMed
Cell size-dependent mRNA transcription drives proteome remodeling.Cell Rep202642275220PubTator, text miningPubMed
Amplification of MED30 at chromosome 8q24 reprograms MYC binding to low-affinity oncogenic enhancers in cancer cells.Cell Rep202642275218PubTator, text miningPubMed
MiR-494-5p suppresses colorectal cancer metastasis by multi-level targeting of KAT2B, a novel mechanism disrupting KAT2B enhancer-promoter looping, and inhibiting c-JUN-driven pro-metastatic properties.
Mol Cancer202642231335PubTator, text miningPubMed
Polyphosphate as a novel regulator of super-enhancer complexes: disruption of phase separation and gene expression.Nucleic Acids Res202642186815PubTator, text miningPubMed
Similarities and Differences of Multiple Epiphyseal Dysplasias: Genetic Features and Natural Course in 22 Patients.Genes (Basel)202642074581PubTator, text miningPubMed
Distinctive Behavior and Selective Modulation of PPARγ by Pentacyclic Triterpenoid Pomolic Acid and Hederagenin from Rosa canina.J Agric Food Chem202642057314PubTator, text miningPubMed

1 to 10 of 2,516

See all 2,516 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5469

GET https://conductscience.org/api/genes/v1/5469/patents?page=2