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Gene · 5471

PPAT: phosphoribosyl pyrophosphate amidotransferase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PPAT: phosphoribosyl pyrophosphate amidotransferase. Genes, record 5471. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5471

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Gene

Symbol
PPAT
HGNC
Name
phosphoribosyl pyrophosphate amidotransferase
HGNC
NCBI Gene ID
5471
NCBI Gene
HGNC ID
HGNC:9238
HGNC
Ensembl
ENSG00000128059
NCBI Gene
Aliases
ATASE, GPAT, PRAT
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q06203Amidophosphoribosyltransferase5173Ensembl, GeneID, HGNC

Source UniProt

Patents18

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1457989Q06203Espacenet
EP 4650780 A22025-11-192322Q06203Espacenet
EP 4641201 A22025-10-291884Q06203Espacenet
JP 2025517969 A2025-06-121884Q06203Espacenet
JP 2025517970 A2025-06-122322Q06203Espacenet
US 11446398 B22022-09-2063546Q06203Espacenet
JP 2022524081 A2022-04-27166517Q06203Espacenet
US 11078247 B22021-08-038787Q06203Espacenet
WO 2020043864 A12020-03-051998Q06203Espacenet
JP 2019054813 A2019-04-11238424Q06203Espacenet

1 to 10 of 18

See all 18 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AZATHIOPRINECHEMBL1542Amidophosphoribosyltransferase inhibitorINHIBITORChEMBL
AZATHIOPRINE SODIUMCHEMBL1200400Amidophosphoribosyltransferase inhibitorINHIBITORChEMBL
MERCAPTOPURINECHEMBL1200751Amidophosphoribosyltransferase inhibitorINHIBITORChEMBL
MERCAPTOPURINE ANHYDROUSCHEMBL1425Amidophosphoribosyltransferase inhibitorINHIBITORChEMBL

Trials264

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07462299MERCAPTOPURINEClinicalTrials.gov
NCT07431060MERCAPTOPURINEClinicalTrials.gov
NCT07424040AZATHIOPRINEClinicalTrials.gov
NCT07235904AZATHIOPRINEPHASE4ClinicalTrials.gov
NCT07227584MERCAPTOPURINEPHASE2ClinicalTrials.gov
NCT07168161AZATHIOPRINEPHASE3ClinicalTrials.gov
NCT07072585MERCAPTOPURINEPHASE2/PHASE3ClinicalTrials.gov
NCT07059156MERCAPTOPURINEPHASE2/PHASE3ClinicalTrials.gov
NCT07044141AZATHIOPRINEPHASE1ClinicalTrials.gov
NCT07012239AZATHIOPRINEClinicalTrials.gov

1 to 10 of 264

See all 264 trials

NIH grants616

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePPAT papersNewest fiscal year
R01CA051497Defining the Role of the Cancer Circadian Clock in Tumor Immunity and Tumorigenesis52025
P30CA008748Cancer Center Support Grant42025
P30ES019776HERCULES: Exposome Research Center42025
P30CA021765Cancer Center Support Grant (CCSG)32025
P30CA023108Cancer Center Support Grant32025
P30ES013508Center of Excellence in Environmental Toxicology32025
ZIAHD008814Mammalian iron-sulfur cluster biogenesis32025
P30AG062715Wisconsin Alzheimer's Disease Research Center22025
P30CA006973Regional Oncology Research Center22025
P30CA013148Comprehensive Cancer Center Support Grant22025

1 to 10 of 616Source NIH's project files

See all 616 nih grants

Papers802

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Metabolite glues as a means of purine sensing and chemotherapeutic response.Nature202642457960PubTator, text miningPubMed
Cucurbitacin B targets PPAT to suppress de novo purine biosynthesis in esophageal squamous cell carcinoma.Phytomedicine202642259163PubTator, text miningPubMed
The oncogenic control of nucleotide synthesis.Oncogenesis202641881963PubTator, text miningPubMed
Redox cycling nitroxide limits cellular iron availability and selectively inhibits iron-sulfur cluster metabolism.Cell Death Discov202641872136PubTator, text miningPubMed
The Plasmodium falciparum PPCS is a unique heteromeric complex with prokaryote-like activity and is a target of pantothenate analogs.Sci Adv202641824577PubTator, text miningPubMed
De novo purine synthesis reprograms the macrophage inflammatory response and the immune response in sepsis.Res Sq202641756441PubTator, text miningPubMed
Antisense Dipeptide Repeat Proteins Drive Widescale Purine Metabolism Aberration in C9orf72 Amyotrophic Lateral Sclerosis via ADA.Int J Mol Sci202641752089PubTator, text miningPubMed
Obesogens in Prostate Cancer: An Endocrine and Metabolic Threat.Curr Obes Rep202641739363PubTator, text miningPubMed
Targeting Metabolic Vulnerabilities in Glioblastoma: a Framework for Multi-node Combination Therapy.Curr Oncol Rep202641718834PubTator, text miningPubMed
Cross-feeding options define genome evolution and community assembly of deep groundwater microbiome.Environ Microbiome202641703668PubTator, text miningPubMed

1 to 10 of 802

See all 802 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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