Gene · 5471
PPAT: phosphoribosyl pyrophosphate amidotransferase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PPAT: phosphoribosyl pyrophosphate amidotransferase. Genes, record 5471. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5471
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q06203 | Amidophosphoribosyltransferase | 517 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents18
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 57989 | Q06203 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2322 | Q06203 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1884 | Q06203 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1884 | Q06203 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2322 | Q06203 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 63546 | Q06203 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 166517 | Q06203 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 8787 | Q06203 | Espacenet |
| WO 2020043864 A1 | 2020-03-05 | 1998 | Q06203 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 238424 | Q06203 | Espacenet |
1 to 10 of 18
See all 18 patentsDrugs4
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| AZATHIOPRINE | CHEMBL1542 | Amidophosphoribosyltransferase inhibitor | INHIBITOR | ChEMBL |
| AZATHIOPRINE SODIUM | CHEMBL1200400 | Amidophosphoribosyltransferase inhibitor | INHIBITOR | ChEMBL |
| MERCAPTOPURINE | CHEMBL1200751 | Amidophosphoribosyltransferase inhibitor | INHIBITOR | ChEMBL |
| MERCAPTOPURINE ANHYDROUS | CHEMBL1425 | Amidophosphoribosyltransferase inhibitor | INHIBITOR | ChEMBL |
Trials264
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07462299 | MERCAPTOPURINE | ClinicalTrials.gov | ||
| NCT07431060 | MERCAPTOPURINE | ClinicalTrials.gov | ||
| NCT07424040 | AZATHIOPRINE | ClinicalTrials.gov | ||
| NCT07235904 | AZATHIOPRINE | PHASE4 | ClinicalTrials.gov | |
| NCT07227584 | MERCAPTOPURINE | PHASE2 | ClinicalTrials.gov | |
| NCT07168161 | AZATHIOPRINE | PHASE3 | ClinicalTrials.gov | |
| NCT07072585 | MERCAPTOPURINE | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07059156 | MERCAPTOPURINE | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07044141 | AZATHIOPRINE | PHASE1 | ClinicalTrials.gov | |
| NCT07012239 | AZATHIOPRINE | ClinicalTrials.gov |
1 to 10 of 264
See all 264 trialsNIH grants616
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PPAT papers | Newest fiscal year |
|---|---|---|---|
| R01CA051497 | Defining the Role of the Cancer Circadian Clock in Tumor Immunity and Tumorigenesis | 5 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 4 | 2025 |
| P30ES019776 | HERCULES: Exposome Research Center | 4 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 3 | 2025 |
| P30CA023108 | Cancer Center Support Grant | 3 | 2025 |
| P30ES013508 | Center of Excellence in Environmental Toxicology | 3 | 2025 |
| ZIAHD008814 | Mammalian iron-sulfur cluster biogenesis | 3 | 2025 |
| P30AG062715 | Wisconsin Alzheimer's Disease Research Center | 2 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 2 | 2025 |
| P30CA013148 | Comprehensive Cancer Center Support Grant | 2 | 2025 |
1 to 10 of 616Source NIH's project files
See all 616 nih grantsPapers802
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Metabolite glues as a means of purine sensing and chemotherapeutic response. | Nature | 2026 | 42457960 | PubTator, text mining | PubMed |
| Cucurbitacin B targets PPAT to suppress de novo purine biosynthesis in esophageal squamous cell carcinoma. | Phytomedicine | 2026 | 42259163 | PubTator, text mining | PubMed |
| The oncogenic control of nucleotide synthesis. | Oncogenesis | 2026 | 41881963 | PubTator, text mining | PubMed |
| Redox cycling nitroxide limits cellular iron availability and selectively inhibits iron-sulfur cluster metabolism. | Cell Death Discov | 2026 | 41872136 | PubTator, text mining | PubMed |
| The Plasmodium falciparum PPCS is a unique heteromeric complex with prokaryote-like activity and is a target of pantothenate analogs. | Sci Adv | 2026 | 41824577 | PubTator, text mining | PubMed |
| De novo purine synthesis reprograms the macrophage inflammatory response and the immune response in sepsis. | Res Sq | 2026 | 41756441 | PubTator, text mining | PubMed |
| Antisense Dipeptide Repeat Proteins Drive Widescale Purine Metabolism Aberration in C9orf72 Amyotrophic Lateral Sclerosis via ADA. | Int J Mol Sci | 2026 | 41752089 | PubTator, text mining | PubMed |
| Obesogens in Prostate Cancer: An Endocrine and Metabolic Threat. | Curr Obes Rep | 2026 | 41739363 | PubTator, text mining | PubMed |
| Targeting Metabolic Vulnerabilities in Glioblastoma: a Framework for Multi-node Combination Therapy. | Curr Oncol Rep | 2026 | 41718834 | PubTator, text mining | PubMed |
| Cross-feeding options define genome evolution and community assembly of deep groundwater microbiome. | Environ Microbiome | 2026 | 41703668 | PubTator, text mining | PubMed |
1 to 10 of 802
See all 802 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5471
GET https://conductscience.org/api/genes/v1/5471/patents