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PPIA: peptidylprolyl isomerase A

1 protein, 146 patents, 3 drugs, 407 trials, 3,232 NIH grants and 5,615 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPPIAHGNC
Namepeptidylprolyl isomerase AHGNC
NCBI Gene ID5478NCBI Gene
HGNC IDHGNC:9253HGNC
EnsemblENSG00000196262NCBI Gene
AliasesCYPA, CYPH, HEL-S-69pNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P62937Peptidyl-prolyl cis-trans isomerase A165205Ensembl, GeneID, HGNCUniProt

Patents 146

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4802067 A12026-09-092P62937Espacenet
EP 4795155 A12026-08-261180P62937Espacenet
US 12624353 B22026-05-12490P62937Espacenet
US 12624354 B22026-05-12490P62937Espacenet
JP 2026062659 A2026-04-10490P62937Espacenet
US 12570972 B22026-03-10490P62937Espacenet
EP 4683650 A22026-01-28461P62937Espacenet
JP 2026004568 A2026-01-1457312P62937Espacenet
US 12509680 B22025-12-30490P62937Espacenet
US 12460199 B22025-11-0480P62937Espacenet

Drugs 3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALISPORIVIRCHEMBL1651956Cyclophilin A inhibitorINHIBITORChEMBL
CYCLOSPORINECHEMBL160Cyclophilin A modulatorMODULATORChEMBL
SCY 635CHEMBL1269597Cyclophilin A inhibitorINHIBITORChEMBL

Trials 407

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07566377CYCLOSPORINEPHASE2ClinicalTrials.gov
NCT07558434CYCLOSPORINEPHASE2ClinicalTrials.gov
NCT07548671CYCLOSPORINEPHASE3ClinicalTrials.gov
NCT07523009CYCLOSPORINEPHASE2ClinicalTrials.gov
NCT07406932CYCLOSPORINEClinicalTrials.gov
NCT07375654CYCLOSPORINEPHASE1ClinicalTrials.gov
NCT07345000CYCLOSPORINEPHASE3ClinicalTrials.gov
NCT07171710CYCLOSPORINEClinicalTrials.gov
NCT07108530CYCLOSPORINEPHASE2ClinicalTrials.gov
NCT07059156CYCLOSPORINEPHASE2/PHASE3ClinicalTrials.gov

NIH grants 3232

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01AI052014HIV-1 Preintegration Trafficking and Nuclear Localization212,025NIH's project files
R01AI129862Imaging early steps of HIV-1 infection and virus-host factor interactions152,025NIH's project files
R01AI120860Development of HIV capsid-targeting antivirals that affect immune response by modulating capsid stability and have improved resistance profiles142,025NIH's project files
P30CA016672Cancer Center Support Grant132,025NIH's project files
P30AI027763UCSF-Bay Area Center for AIDS Research122,025NIH's project files
U54AI170791Pittsburgh Center for HIV Protein Interactions (PCHPI)102,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant92,025NIH's project files
R28AA012725Brain Tissue Resource Center for Alcohol Research92,025NIH's project files
R01AI100720Evolutionary potential of HIV-1 capsid: mechanisms and consequences82,025NIH's project files
P30AI110527Tennessee Center for AIDS Research (TN-CFAR)72,025NIH's project files

Papers 5615

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42814859PubTator, text miningPubMed
42806361PubTator, text miningPubMed
42801429PubTator, text miningPubMed
42798836PubTator, text miningPubMed
42773474PubTator, text miningPubMed
42771608PubTator, text miningPubMed
42724846PubTator, text miningPubMed
42723078PubTator, text miningPubMed
42714160PubTator, text miningPubMed
42665867PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license