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Gene · 5479

PPIB: peptidylprolyl isomerase B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PPIB: peptidylprolyl isomerase B. Genes, record 5479. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5479

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Gene

Symbol
PPIB
HGNC
Name
peptidylprolyl isomerase B
HGNC
NCBI Gene ID
5479
NCBI Gene
HGNC ID
HGNC:9255
HGNC
Ensembl
ENSG00000166794
NCBI Gene
Aliases
B, CYP-S1, CYPB, HEL-S-39, OI9, PPIase, SCYLP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P23284Peptidyl-prolyl cis-trans isomerase B2168Ensembl, GeneID, HGNC

Source UniProt

Patents101

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12624353 B22026-05-12493P23284Espacenet
US 12624354 B22026-05-12493P23284Espacenet
JP 2026062659 A2026-04-10493P23284Espacenet
US 12570972 B22026-03-10493P23284Espacenet
JP 2026004568 A2026-01-1457314P23284Espacenet
US 12509680 B22025-12-30493P23284Espacenet
EP 4650780 A22025-11-193974P23284Espacenet
JP 2025147176 A2025-10-0610671P23284Espacenet
JP 2025529142 A2025-09-047408P23284Espacenet
US 12371689 B22025-07-297408P23284Espacenet

1 to 10 of 101

See all 101 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,634

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePPIB papersNewest fiscal year
P30CA008748Cancer Center Support Grant132025
ZIAHD000256Collagen-related diseases82025
P30CA016672Cancer Center Support Grant62025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202852025
P30CA142543UT Southwestern Medical Center Simmons Comprehensive Cancer Center52025
P30DK020572Michigan Diabetes Research Center (MDRC)52025
P30CA006927Comprehensive Cancer Center Program at Fox Chase42025
P30CA068485Cancer Center Support Grant42025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant42025
R35GM119840Chemical biology approaches to probe signaling by protein lipidation42025

1 to 10 of 1,634Source NIH's project files

See all 1,634 nih grants

Papers2,141

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
PPIB and its role in prostate cancer: associations with transcriptomic and splicing alterations.Front Oncol202642774112PubTator, text miningPubMed
Correction: PPIB interacts with MET to activate the PI3K-AKT pathway and promote head and neck squamous cell carcinoma pathogenesis.Mol Biol Rep202642714721PubTator, text miningPubMed
Prognostic Significance and Functional Role of PPIB in a Retrospective Cohort of Patients with Advanced Gastric Cancer.Oncol Res202642630697PubTator, text miningPubMed
PPIB interacts with MET to activate the PI3K-AKT pathway and promote head and neck squamous cell carcinoma pathogenesis.Mol Biol Rep202642611118PubTator, text miningPubMed
Multimodal Single-Cell Network Analysis Identifies Basigin/Cluster of Differentiation 147 as a Tumor-Associated Signaling Hub in Hepatocellular Carcinoma.Gastro Hep Adv202642598059PubTator, text miningPubMed
Proteomic Differentiation of Colorectal Cancer From Normal Tissue via Ex Vivo E-Biopsy: A Novel Approach to Molecular Sampling for Diagnostic Precision.Cancer Med202642576270PubTator, text miningPubMed
Peptidyl-prolyl isomerase B suppresses BEFV- and VSV-induced type I interferon responses via degradation of PBLD.Vet Microbiol202642456219PubTator, text miningPubMed
Biotransformation mechanisms of polycyclic aromatic hydrocarbons by Raphidocelis subcapitata: The role of cytochrome P450.Ecotoxicol Environ Saf202642391845PubTator, text miningPubMed
A Novel CAF-Related Signature for Precise Prediction of Clinical Outcomes and Immunotherapy Response for Breast Cancer Patients: Based on Multiomics Analyses and Experimental Validation.Mediators Inflamm202642359574PubTator, text miningPubMed
Cross-Platform Comparative Spatial Transcriptomics in High-Grade Serous Carcinoma.Lab Invest202642142589PubTator, text miningPubMed

1 to 10 of 2,141

See all 2,141 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5479

GET https://conductscience.org/api/genes/v1/5479/patents?page=2