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Gene · 5481

PPID: peptidylprolyl isomerase D

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PPID: peptidylprolyl isomerase D. Genes, record 5481. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5481

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Gene

Symbol
PPID
HGNC
Name
peptidylprolyl isomerase D
HGNC
NCBI Gene ID
5481
NCBI Gene
HGNC ID
HGNC:9257
HGNC
Ensembl
ENSG00000171497
NCBI Gene
Aliases
CYP-40, CYPD, CypD
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q08752Peptidyl-prolyl cis-trans isomerase D3700Ensembl, GeneID, HGNC

Source UniProt

Patents35

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1457316Q08752Espacenet
EP 4650780 A22025-11-194232Q08752Espacenet
EP 4641201 A22025-10-293785Q08752Espacenet
JP 2025517969 A2025-06-123785Q08752Espacenet
JP 2025517970 A2025-06-124232Q08752Espacenet
JP 2025009766 A2025-01-2093Q08752Espacenet
WO 2025005189 A2025-01-0293Q08752Espacenet
US 11892452 B22024-02-06119Q08752Espacenet
US 11860162 B22024-01-021531Q08752Espacenet
US 11446398 B22022-09-2061868Q08752Espacenet

1 to 10 of 35

See all 35 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants926

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePPID papersNewest fiscal year
ZIAHL002066Mechanisms of cardiac ischemia-reperfusion injury and cardioprotection112025
P30CA010815Consolidated Basic Cancer Research Program62025
R01NS073899The hsp90 Cochaperone FKBP51 Regulates tau Structure and Function52025
P30AR069655Rochester Resource-Based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR) (Overall Application)42025
P30CA008748Cancer Center Support Grant32025
P30CA016056Roswell Park Cancer Center Support Grant32025
R01AG059753GOAT-mediated ghrelin deregulation and hippocampal pathology in Alzheimer's Disease32025
R01AR070613Raman spectroscopic platform for transcutaneous monitoring of bone quality32025
R01HL122124Mitochondria-SR Tethering: Its Role in Cardiac Bioenergetics and Ca2+ Dynamics32025
ZIAHL005102Metabolic pathways linked to immunity32025

1 to 10 of 926Source NIH's project files

See all 926 nih grants

Papers1,476

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Structure-Based Screening Identifies Polyphenol Glucuronides as Cyclophilin D Ligands.Molecules202642738733PubTator, text miningPubMed
Ferroptosis-Mitochondrial Crosstalk in Cardiomyocyte Death: The Cardiomyocyte Ferroptotic Amplification Circuit (CFAC) as a Proposed, Testable Systems Framework.Cardiovasc Toxicol202642726159PubTator, text miningPubMed
Cyclophilin D at the Heart of Neonatal Hypoxia.JACC Basic Transl Sci202642200587PubTator, text miningPubMed
Systematic discovery of pro- and anti-HIV host factors in primary human CD4+ T cells.Cell202642013838PubTator, text miningPubMed
Cyclophilin D, Regulator of Mitochondrial Permeability Transition and Bioenergetics, Promotes Adipogenic Differentiation of Mesenchymal Stem Cells.Cells202641892300PubTator, text miningPubMed
Structure-based design of pyrazole derivatives targeting the human Cyclophilin D binding site.Int J Biol Macromol202641881208PubTator, text miningPubMed
Overcoming the blood‒brain barrier: nanomedicine strategies for targeted delivery and multimodal therapy in Alzheimer's disease.Drug Deliv202641863079PubTator, text miningPubMed
A preclinical candidate of cyclophilin D inhibition improves alcohol-associated liver injury.Cell Rep Med202641850244PubTator, text miningPubMed
Efficient Binding Affinity Estimation for Fragment-Based Compounds Using a Separated Topologies Approach.J Chem Inf Model202641824423PubTator, text miningPubMed
Mitochondrial Resilience: Unraveling the Triadic Interplay of Phosphocreatine, Cyclophilin D, and STAT3 in Heart Failure.J Cardiovasc Transl Res202641790403PubTator, text miningPubMed

1 to 10 of 1,476

See all 1,476 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5481

GET https://conductscience.org/api/genes/v1/5481/patents?page=2