Gene · 54840
APTX: aprataxin
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. APTX: aprataxin. Genes, record 54840. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/54840
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q7Z2E3 | Aprataxin | 356 | 11 | Ensembl, GeneID, HGNC |
Source UniProt
Patents12
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 37736 | Q7Z2E3 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 40787 | Q7Z2E3 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 40787 | Q7Z2E3 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 5908 | Q7Z2E3 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 5908 | Q7Z2E3 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 108879 | Q7Z2E3 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 674 | Q7Z2E3 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 218171 | Q7Z2E3 | Espacenet |
| JP 2017121241 A | 2017-07-13 | 218171 | Q7Z2E3 | Espacenet |
| JP 2015516143 A | 2015-06-08 | 218171 | Q7Z2E3 | Espacenet |
1 to 10 of 12
See all 12 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants727
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | APTX papers | Newest fiscal year |
|---|---|---|---|
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 36 | 2025 |
| ZIAAG000723 | ALZHEIMERS RESEARCH PROJECT: DNA repair dysfunction in neurodegeneration and Alzheimer's Disease | 11 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 10 | 2025 |
| P01CA096832 | NORMAL & NEOPLASTIC GROWTH IN THE BRAIN | 9 | 2025 |
| R01ES012512 | Roles of Lig3 and XRCC1 Genes in Genome Stability | 8 | 2025 |
| ZIAES102765 | Structural Biology of Genome Maintenance and DNA repair | 7 | 2025 |
| ZIAES065070 | Structure-Function Studies Of DNA Replication Fidelity | 5 | 2025 |
| R35CA220430 | Mesoscale and Nanoscale Technologies Integrated by Structures for DNA Repair Complexes (MANTIS-DRC) | 4 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 727Source NIH's project files
See all 727 nih grantsPapers1,316
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| APTX deficiency is associated with altered neuronal differentiation and alternative splicing in patient-derived neurons. | Neurobiol Dis | 2026 | 42624379 | PubTator, text mining | PubMed |
| Dissolved organic matter molecular composition links water chemistry, microbial functional potential, and nitrous oxide variability in a temperate estuary. | Water Res | 2026 | 42546526 | PubTator, text mining | PubMed |
| Spotted knapweed (Centaurea stoebe) invasion linked with disruption of soil nitrogen-cycling processes. | J Environ Manage | 2026 | 42430987 | PubTator, text mining | PubMed |
| Cell-type-specific genetic architecture reveals neuronal and immune contributions to neuropsychiatric disorders. | Mol Psychiatry | 2026 | 42020718 | PubTator, text mining | PubMed |
| Spatial and seasonal dynamics of nitrification pathways in sandy sediments along the Guangdong Coast, China. | Mar Pollut Bull | 2026 | 41819688 | PubTator, text mining | PubMed |
| Zinc finger proteins (ZFPs) in health and disease. | Mol Biomed | 2026 | 41772312 | PubTator, text mining | PubMed |
| Huntington's disease LIG1 modifier variant increases ligase fidelity and suppresses somatic CAG repeat expansion. | Proc Natl Acad Sci U S A | 2026 | 41770933 | PubTator, text mining | PubMed |
| Synergistic Cellular Toxicity from Inhibition of Poly(ADP-ribose) Glycohydrolase (PARG) and Ubiquitin-Specific Protease 1 (USP1). | Toxics | 2026 | 41745836 | PubTator, text mining | PubMed |
| Elevated temperature simulating heatwaves restructures active nitrifying communities and associated viruses in tidal flats and agricultural soils. | ISME J | 2026 | 41714186 | PubTator, text mining | PubMed |
| Plant-mediated niche differentiation promotes comammox-dominated nitrification in aquaponic rhizospheres. | Sci Total Environ | 2026 | 41671814 | PubTator, text mining | PubMed |
1 to 10 of 1,316
See all 1,316 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/54840
GET https://conductscience.org/api/genes/v1/54840/patents