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Gene · 54888

NSUN2: NOP2/Sun RNA methyltransferase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NSUN2: NOP2/Sun RNA methyltransferase 2. Genes, record 54888. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/54888

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Gene

Symbol
NSUN2
HGNC
Name
NOP2/Sun RNA methyltransferase 2
HGNC
NCBI Gene ID
54888
NCBI Gene
HGNC ID
HGNC:25994
HGNC
Ensembl
ENSG00000037474
NCBI Gene
Aliases
FLJ20303, MISU, MRT5, Misu, SAKI, TRM4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q08J23RNA cytosine C(5)-methyltransferase NSUN276710Ensembl, GeneID, HGNC

Source UniProt

Patents16

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1455919Q08J23Espacenet
EP 4650780 A22025-11-192381Q08J23Espacenet
EP 4641201 A22025-10-291957Q08J23Espacenet
JP 2025517969 A2025-06-121957Q08J23Espacenet
JP 2025517970 A2025-06-122381Q08J23Espacenet
JP 2024542995 A2024-11-19206Q08J23Espacenet
JP 2023553935 A2023-12-261023Q08J23Espacenet
KR 1020230129996 A2023-09-111013Q08J23Espacenet
US 11446398 B22022-09-2057661Q08J23Espacenet
JP 2022524081 A2022-04-27160632Q08J23Espacenet

1 to 10 of 16

See all 16 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants587

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNSUN2 papersNewest fiscal year
RM1HG008935Center for dynamic RNA epitranscriptomes - Renewal82025
ZIAAG000393Influence of Post-transcriptional Gene Regulation on Cell Senescence and Aging72025
R01GM052347tRNA Processing62025
P30CA016058Cancer Center Support Grant32025
R01GM101316Functions of mRNA Pseudouridylation32025
R01HD092431Sperm tsRNAs/rsRNAs and their RNA modifications in diet-induced epigenetic inheritance32025
R35ES031707Chemical Biology of DNA and RNA Alkylation32025
R35NS116843Continuous Neurogenesis in the Mammalian Hippocampus32025
T32CA009594Multi-Disciplinary Training Grant in Cancer Research32025
P30AI027763UCSF-Bay Area Center for AIDS Research22025

1 to 10 of 587Source NIH's project files

See all 587 nih grants

Papers1,406

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
RNA-Binding Peptide Influences Epitranscriptomic Regulation by Preferentially Binding to Unmodified RNAs Targeted by NSUN2.Biomolecules202642793119PubTator, text miningPubMed
NSUN2-mediated m5C modification of HIV-1 RNA enables evasion of RIG‑I‑dependent innate immunity.PLoS Pathog202642789514PubTator, text miningPubMed
RNA derived from cancer cells as a scaffold for amyloid-β25-35 aggregation: the effect of RNA methylation and rRNA status.Int J Biol Macromol202642785408PubTator, text miningPubMed
NSUN2 promotes glycolysis and stemness of retinoblastoma cells by m5C modification of PFKFB3.Tissue Cell202642753463PubTator, text miningPubMed
5-Azacytosine induces cytotoxicity via 5-methylcytosine depletion on chromatin-associated RNA in leukemia.Mol Cell202642743920PubTator, text miningPubMed
Tumor-intrinsic NSUN2 orchestrates immunosuppression in lung adenocarcinoma via the m5C-HDAC8-CCL5 axis.Exp Hematol Oncol202642706582PubTator, text miningPubMed
Cellular signal-responsive m5C editing by an inducible split CRISPR platform.RNA202642680563PubTator, text miningPubMed
Metabolic Reprogramming of NSUN2-Mediated m5C Modification Promotes the Progression of Hepatocellular Carcinoma by Restricting Natural Killer Cell-Mediated Cytotoxicity.Cancer Commun (Lond)202642676762PubTator, text miningPubMed
NSUN2 Promotes Cancer Immune Evasion via Its Moonlighting Function Acting on Metabolic Reprogramming.Cancer Commun (Lond)202642620795PubTator, text miningPubMed
A m6A/m1A/m5C-related eight-gene signature predicts prognosis and correlates with immune microenvironment in pediatric acute myeloid leukemia.Transl Pediatr202642591630PubTator, text miningPubMed

1 to 10 of 1,406

See all 1,406 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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