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Gene · 54894

RNF43: ring finger protein 43

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RNF43: ring finger protein 43. Genes, record 54894. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/54894

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Gene

Symbol
RNF43
HGNC
Name
ring finger protein 43
HGNC
NCBI Gene ID
54894
NCBI Gene
HGNC ID
HGNC:18505
HGNC
Ensembl
ENSG00000108375
NCBI Gene
Aliases
DKFZp781H0392, FLJ20315, RNF124, SSPCS, URCC
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q68DV7E3 ubiquitin-protein ligase RNF437832Ensembl, GeneID, HGNC

Source UniProt

Patents86

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026120541 A2026-07-221Q68DV7Espacenet
JP 2026082857 A2026-05-191Q68DV7Espacenet
JP 2026004568 A2026-01-1462338Q68DV7Espacenet
EP 4650780 A22025-11-1911917Q68DV7Espacenet
EP 4640849 A22025-10-291913Q68DV7Espacenet
EP 4641201 A22025-10-2912733Q68DV7Espacenet
JP 2025533403 A2025-10-0711Q68DV7Espacenet
JP 2025529142 A2025-09-043758Q68DV7Espacenet
US 12371689 B22025-07-293758Q68DV7Espacenet
JP 2025519096 A2025-06-241913Q68DV7Espacenet

1 to 10 of 86

See all 86 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,226

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRNF43 papersNewest fiscal year
P30CA008748Cancer Center Support Grant482025
P30CA006973Regional Oncology Research Center272025
P30CA016672Cancer Center Support Grant162025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)122025
P30CA076292Moffitt Cancer Center Support Grant82025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant62025
P30DK120531Pittsburgh Liver Research Center62025
P50CA186786Michigan Prostate SPORE 2025-203062025
U01CA200466Validation of biomarkers for risk prediction and early diagnosis of Pancreatic Adenocarcinoma62025
P30CA016086Cancer Center Support Grant52025

1 to 10 of 1,226Source NIH's project files

See all 1,226 nih grants

Papers2,200

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.Sci Adv202642777043PubTator, text miningPubMed
Clinicopathologic Features, Treatment Patterns, and Outcomes of Microsatellite Instability-High Gastric and Gastroesophageal Junction Adenocarcinoma: A Single-Institution Retrospective Analysis.JCO Precis Oncol202642753221PubTator, text miningPubMed
RNF research trends and an RNF43-based prognostic model for colorectal cancer with immune microenvironment analysis.Discov Oncol202642671492PubTator, text miningPubMed
NECTIN4 (PVRL4) expression in pancreatic cancer patients might be associated with a more unfavorable prognosis, independent of age at diagnosis, sex, and stage: A public microarray and RNA sequencing data based bioinformatics analysis.
Comput Biol Chem202642567085PubTator, text miningPubMed
Deletion of the Wnt regulator Znrf3 alters bone geometry without inducing high bone mass.Bone202642520949PubTator, text miningPubMed
Artificial Intelligence-Enabled Analysis of WNT Pathway Dysregulation in Bevacizumab-Treated Early-Onset Colorectal Cancer.Int J Mol Sci202642511540PubTator, text miningPubMed
Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas: History, Myths, and Realities Between Past and Future.Med Sci (Basel)202642506374PubTator, text miningPubMed
SOMATIC MUTATION PROFILES IN COLORECTAL CANCERS DIFFER BY POPULATION.medRxiv202642428056PubTator, text miningPubMed
ZNRF3 and RNF43 are active monomeric E3 ubiquitin ligases that self-associate.Sci Signal202642378331PubTator, text miningPubMed
Prostate Cancer: Etiology, Diagnosis, and Treatment.Serican J Med202642375929PubTator, text miningPubMed

1 to 10 of 2,200

See all 2,200 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/54894

GET https://conductscience.org/api/genes/v1/54894/patents?page=2