Gene · 54894
RNF43: ring finger protein 43
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. RNF43: ring finger protein 43. Genes, record 54894. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/54894
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q68DV7 | E3 ubiquitin-protein ligase RNF43 | 783 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents86
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026120541 A | 2026-07-22 | 1 | Q68DV7 | Espacenet |
| JP 2026082857 A | 2026-05-19 | 1 | Q68DV7 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 62338 | Q68DV7 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 11917 | Q68DV7 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 1913 | Q68DV7 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 12733 | Q68DV7 | Espacenet |
| JP 2025533403 A | 2025-10-07 | 11 | Q68DV7 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3758 | Q68DV7 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3758 | Q68DV7 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 1913 | Q68DV7 | Espacenet |
1 to 10 of 86
See all 86 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,226
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | RNF43 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 48 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 27 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 16 | 2025 |
| P30CA014089 | University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG) | 12 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 8 | 2025 |
| P30CA015083 | Mayo Clinic Comprehensive Cancer Center Support Grant | 6 | 2025 |
| P30DK120531 | Pittsburgh Liver Research Center | 6 | 2025 |
| P50CA186786 | Michigan Prostate SPORE 2025-2030 | 6 | 2025 |
| U01CA200466 | Validation of biomarkers for risk prediction and early diagnosis of Pancreatic Adenocarcinoma | 6 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 5 | 2025 |
1 to 10 of 1,226Source NIH's project files
See all 1,226 nih grantsPapers2,200
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation. | Sci Adv | 2026 | 42777043 | PubTator, text mining | PubMed |
| Clinicopathologic Features, Treatment Patterns, and Outcomes of Microsatellite Instability-High Gastric and Gastroesophageal Junction Adenocarcinoma: A Single-Institution Retrospective Analysis. | JCO Precis Oncol | 2026 | 42753221 | PubTator, text mining | PubMed |
| RNF research trends and an RNF43-based prognostic model for colorectal cancer with immune microenvironment analysis. | Discov Oncol | 2026 | 42671492 | PubTator, text mining | PubMed |
NECTIN4 (PVRL4) expression in pancreatic cancer patients might be associated with a more unfavorable prognosis, independent of age at diagnosis, sex, and stage: A public microarray and RNA sequencing data based bioinformatics analysis. | Comput Biol Chem | 2026 | 42567085 | PubTator, text mining | PubMed |
| Deletion of the Wnt regulator Znrf3 alters bone geometry without inducing high bone mass. | Bone | 2026 | 42520949 | PubTator, text mining | PubMed |
| Artificial Intelligence-Enabled Analysis of WNT Pathway Dysregulation in Bevacizumab-Treated Early-Onset Colorectal Cancer. | Int J Mol Sci | 2026 | 42511540 | PubTator, text mining | PubMed |
| Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas: History, Myths, and Realities Between Past and Future. | Med Sci (Basel) | 2026 | 42506374 | PubTator, text mining | PubMed |
| SOMATIC MUTATION PROFILES IN COLORECTAL CANCERS DIFFER BY POPULATION. | medRxiv | 2026 | 42428056 | PubTator, text mining | PubMed |
| ZNRF3 and RNF43 are active monomeric E3 ubiquitin ligases that self-associate. | Sci Signal | 2026 | 42378331 | PubTator, text mining | PubMed |
| Prostate Cancer: Etiology, Diagnosis, and Treatment. | Serican J Med | 2026 | 42375929 | PubTator, text mining | PubMed |
1 to 10 of 2,200
See all 2,200 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
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The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/54894
GET https://conductscience.org/api/genes/v1/54894/patents?page=2