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Gene · 54901

CDKAL1: CDKAL1 threonylcarbamoyladenosine tRNA methylthiotransferase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CDKAL1: CDKAL1 threonylcarbamoyladenosine tRNA methylthiotransferase. Genes, record 54901. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/54901

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Gene

Symbol
CDKAL1
HGNC
Name
CDKAL1 threonylcarbamoyladenosine tRNA methylthiotransferase
HGNC
NCBI Gene ID
54901
NCBI Gene
HGNC ID
HGNC:21050
HGNC
Ensembl
ENSG00000145996
NCBI Gene
Aliases
FLJ20342
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q5VV42Threonylcarbamoyladenosine tRNA methylthiotransferase5790Ensembl, GeneID, HGNC

Source UniProt

Patents23

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026066953 A2026-04-171Q5VV42Espacenet
JP 2026004568 A2026-01-1440740Q5VV42Espacenet
JP 2026004568 A2026-01-1440741Q5VV42Espacenet
EP 4650780 A22025-11-192923Q5VV42Espacenet
JP 2025529142 A2025-09-04884Q5VV42Espacenet
US 12371689 B22025-07-29884Q5VV42Espacenet
JP 2025517970 A2025-06-122923Q5VV42Espacenet
US 11446398 B22022-09-2013481Q5VV42Espacenet
US 11446398 B22022-09-2013482Q5VV42Espacenet
US 11400116 B22022-08-024341Q5VV42Espacenet

1 to 10 of 23

See all 23 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,355

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCDKAL1 papersNewest fiscal year
P30DK063491Diabetes Research Center (DRC)212025
P30DK020572Michigan Diabetes Research Center (MDRC)142025
R01DK062370Identifying Genes for Type 2 Diabetes: FUSION142025
ZIAHG000024Genetic analysis of type II diabetes122025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal102025
U19AG055373Trans-omics Integration of Multi-omics Studies for Osteoporosis102025
P20GM109036Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases92025
P30ES010126UNC Center for Environmental Health and Susceptibility82025
R01DK093757Genetic epidemiology of rare and regulatory variants for metabolic traits82025
P30DK056350Nutrition Obesity Research Center (NORC)62025

1 to 10 of 1,355Source NIH's project files

See all 1,355 nih grants

Papers1,409

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
CDKAL1 rs7756992 polymorphism and the risk of type 2 diabetes among Moroccans: A systematic review and meta-analysis.Semergen202642815414PubTator, text miningPubMed
Association of CDKAL1 rs7754840 with gestational diabetes mellitus: a systematic review and meta-analysis.Front Endocrinol (Lausanne)202642787193PubTator, text miningPubMed
Cataract GWAS meta-analysis and multi-omics Mendelian randomisation inform disease mechanisms and candidate target prioritisation.EBioMedicine202642771993PubTator, text miningPubMed
Trans-ancestry meta-analysis of genome-wide association study identifies eight novel genetic loci in type 1 diabetes: A multi-population study.Diabet Med202642594184PubTator, text miningPubMed
Genomic and lipidomic analysis reveals lipid mediation of genetic risk in gestational diabetes.BMC Med202642482087PubTator, text miningPubMed
Genetic determinants of gestational diabetes mellitus in thai pregnant women: role of GCKR, CDKAL1, TCF7L2, NEDD1, and CMIP variants.Ann Med202642466846PubTator, text miningPubMed
Associations of maternal CDKAL1 gene with adverse offspring growth patterns.Pediatr Res202642420513PubTator, text miningPubMed
Maternal CDKAL1 polygenic risk and offspring growth trajectories beyond gestational diabetes.Pediatr Res202642243501PubTator, text miningPubMed
Converging TCF7L2 and CDKAL1 pathways in the pathogenesis of type 2 diabetes mellitus.Acta Diabetol202642223623PubTator, text miningPubMed
Treatment Target Discovery From Vasculo-Protective Phenotypes.J Lipid Atheroscler202642211154PubTator, text miningPubMed

1 to 10 of 1,409

See all 1,409 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/54901

GET https://conductscience.org/api/genes/v1/54901/patents?page=2