Gene · 54901
CDKAL1: CDKAL1 threonylcarbamoyladenosine tRNA methylthiotransferase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CDKAL1: CDKAL1 threonylcarbamoyladenosine tRNA methylthiotransferase. Genes, record 54901. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/54901
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q5VV42 | Threonylcarbamoyladenosine tRNA methylthiotransferase | 579 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents23
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026066953 A | 2026-04-17 | 1 | Q5VV42 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 40740 | Q5VV42 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 40741 | Q5VV42 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2923 | Q5VV42 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 884 | Q5VV42 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 884 | Q5VV42 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2923 | Q5VV42 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 13481 | Q5VV42 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 13482 | Q5VV42 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 4341 | Q5VV42 | Espacenet |
1 to 10 of 23
See all 23 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,355
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CDKAL1 papers | Newest fiscal year |
|---|---|---|---|
| P30DK063491 | Diabetes Research Center (DRC) | 21 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 14 | 2025 |
| R01DK062370 | Identifying Genes for Type 2 Diabetes: FUSION | 14 | 2025 |
| ZIAHG000024 | Genetic analysis of type II diabetes | 12 | 2025 |
| R01HL086694 | From GWAS loci to blood pressure genes, variants & mechanisms - Renewal | 10 | 2025 |
| U19AG055373 | Trans-omics Integration of Multi-omics Studies for Osteoporosis | 10 | 2025 |
| P20GM109036 | Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases | 9 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 8 | 2025 |
| R01DK093757 | Genetic epidemiology of rare and regulatory variants for metabolic traits | 8 | 2025 |
| P30DK056350 | Nutrition Obesity Research Center (NORC) | 6 | 2025 |
1 to 10 of 1,355Source NIH's project files
See all 1,355 nih grantsPapers1,409
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| CDKAL1 rs7756992 polymorphism and the risk of type 2 diabetes among Moroccans: A systematic review and meta-analysis. | Semergen | 2026 | 42815414 | PubTator, text mining | PubMed |
| Association of CDKAL1 rs7754840 with gestational diabetes mellitus: a systematic review and meta-analysis. | Front Endocrinol (Lausanne) | 2026 | 42787193 | PubTator, text mining | PubMed |
| Cataract GWAS meta-analysis and multi-omics Mendelian randomisation inform disease mechanisms and candidate target prioritisation. | EBioMedicine | 2026 | 42771993 | PubTator, text mining | PubMed |
| Trans-ancestry meta-analysis of genome-wide association study identifies eight novel genetic loci in type 1 diabetes: A multi-population study. | Diabet Med | 2026 | 42594184 | PubTator, text mining | PubMed |
| Genomic and lipidomic analysis reveals lipid mediation of genetic risk in gestational diabetes. | BMC Med | 2026 | 42482087 | PubTator, text mining | PubMed |
| Genetic determinants of gestational diabetes mellitus in thai pregnant women: role of GCKR, CDKAL1, TCF7L2, NEDD1, and CMIP variants. | Ann Med | 2026 | 42466846 | PubTator, text mining | PubMed |
| Associations of maternal CDKAL1 gene with adverse offspring growth patterns. | Pediatr Res | 2026 | 42420513 | PubTator, text mining | PubMed |
| Maternal CDKAL1 polygenic risk and offspring growth trajectories beyond gestational diabetes. | Pediatr Res | 2026 | 42243501 | PubTator, text mining | PubMed |
| Converging TCF7L2 and CDKAL1 pathways in the pathogenesis of type 2 diabetes mellitus. | Acta Diabetol | 2026 | 42223623 | PubTator, text mining | PubMed |
| Treatment Target Discovery From Vasculo-Protective Phenotypes. | J Lipid Atheroscler | 2026 | 42211154 | PubTator, text mining | PubMed |
1 to 10 of 1,409
See all 1,409 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/54901
GET https://conductscience.org/api/genes/v1/54901/patents?page=2