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Gene · 5498

PPOX: protoporphyrinogen oxidase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PPOX: protoporphyrinogen oxidase. Genes, record 5498. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5498

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Gene

Symbol
PPOX
HGNC
Name
protoporphyrinogen oxidase
HGNC
NCBI Gene ID
5498
NCBI Gene
HGNC ID
HGNC:9280
HGNC
Ensembl
ENSG00000143224
NCBI Gene
Aliases
PPO, V290M, VP, VPCO
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P50336Protoporphyrinogen oxidase4773Ensembl, GeneID, HGNC

Source UniProt

Patents62

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21103P50336Espacenet
JP 2026004568 A2026-01-1460389P50336Espacenet
JP 2026004568 A2026-01-1460390P50336Espacenet
JP 2025147176 A2025-10-0610679P50336Espacenet
JP 2025147176 A2025-10-0610680P50336Espacenet
JP 2025529142 A2025-09-047410P50336Espacenet
US 12371689 B22025-07-297410P50336Espacenet
JP 2025028160 A2025-02-2810679P50336Espacenet
JP 2025028160 A2025-02-2810680P50336Espacenet
KR 1020250010750 A2025-01-2110679P50336Espacenet

1 to 10 of 62

See all 62 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants345

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePPOX papersNewest fiscal year
U54DK110858Center for Iron & Heme Disorders at the University of Utah82025
P30CA008748Cancer Center Support Grant52025
R01DK074797Inter-organ signaling in heme metabolism and organismal homeostasis.32025
P30CA015704Cancer Center Support Grant22025
P30CA016672Cancer Center Support Grant22025
P30DK026743UCSF Liver Center22025
R01DK098672Regulation of Mitochondrial Function by Orphan Protein Phosphatases22025
K08DK129716Cellular Signaling Pathways in the Regulation of Fetal Hemoglobin for Treatment of Sickle Cell Disease12025
K12HD052896Child Health Research Career Development Award (CHRCDA) Program (K12)12025
K23AR079586Measuring and Understanding Light Sensitivity in Erythropoietic Protoporphyria12025

1 to 10 of 345Source NIH's project files

See all 345 nih grants

Papers1,642

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Hydrodynamic Cavitation in Juice Processing: Linking PME, PPO, and POD Responses to Physicochemical Stability and Quality Retention.Molecules202642796607PubTator, text miningPubMed
Spatiotemporal Dissection of the Infection Response to Bacterial Soft Rot in Non-heading Chinese cabbage.Plant Dis202642754990PubTator, text miningPubMed
Potential mitochondria-associated pathogenic genes in sepsis: a multi-omics Mendelian randomization study.Front Immunol202642694092PubTator, text miningPubMed
Effects of Electrolyzed Functional Water Combined with Modified Atmosphere Storage on Postharvest Quality of Arrow Bamboo Shoots.Foods202642650592PubTator, text miningPubMed
Integrated transcriptomic and metabolomic analyses reveal the regulatory network of alkaloid metabolism in blister blight-infected tea plants.Front Plant Sci202642621026PubTator, text miningPubMed
Tri-frequency ultrasonication priming enhances germination, nutritional quality and techno-functional properties of tartary buckwheat.Ultrason Sonochem202642604605PubTator, text miningPubMed
Draft Genome Assembly and Differential Expression of MpPPO1 and MpPPO2 Across Green-Fruit Development in Ecuadorian Musa paradisiaca L.Plants (Basel)202642588832PubTator, text miningPubMed
High frequency of the PPOX p.Arg168His pathogenic variant among Brazilian patients with variegate porphyria.Mol Genet Metab202642566979PubTator, text miningPubMed
Challenges in Porphyria diagnosis and management: When variegate Porphyria meets HIV.Mol Genet Metab202642566978PubTator, text miningPubMed
Molecular insights into the anti-browning effect of protocatechualdehyde.Int J Biol Macromol202642551667PubTator, text miningPubMed

1 to 10 of 1,642

See all 1,642 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5498

GET https://conductscience.org/api/genes/v1/5498/patents?page=2