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Gene · 5499

PPP1CA: protein phosphatase 1 catalytic subunit alpha

11 sourcesgene-search-2026-11-11-0.1.0

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ConductScience Library. PPP1CA: protein phosphatase 1 catalytic subunit alpha. Genes, record 5499. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/5499

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Gene

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

Symbol
PPP1CA
HGNC
Name
protein phosphatase 1 catalytic subunit alpha
HGNC
NCBI Gene ID
5499
NCBI Gene
HGNC ID
HGNC:9281
HGNC
Ensembl
ENSG00000172531
NCBI Gene
Aliases
PP-1A, PP1A, PP1alpha, PPP1A
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P62136Serine/threonine-protein phosphatase PP1-alpha catalytic subunit33046Ensembl, GeneID, HGNC

Source UniProt

Patents62

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4805736 A22026-09-1630P62136Espacenet
JP 2026004568 A2026-01-1459829P62136Espacenet
EP 4650780 A22025-11-199822P62136Espacenet
JP 2025147176 A2025-10-0610688P62136Espacenet
JP 2025529142 A2025-09-047411P62136Espacenet
US 12371689 B22025-07-297411P62136Espacenet
JP 2025517970 A2025-06-129822P62136Espacenet
JP 2025028160 A2025-02-2810688P62136Espacenet
KR 1020250010750 A2025-01-2110688P62136Espacenet
JP 2024109657 A2024-08-1410695P62136Espacenet

1 to 10 of 62

See all 62 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,909

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal year
P30CA016672Cancer Center Support Grant112025
P30AI117970District of Columbia Center for AIDS Research92025
R35GM119455Mechanisms of Phosphorylation Signaling by Phosphoprotein Phosphatases82025
P20GM113132The Institute for Biomolecular Targeting62025
R01AI158775Development of dual inhibitors targeting the viral main protease and the host cathepsin L as SARS-CoV-2 antivirals62025
U54MD007597Howard University Research Center for Minority Health and Health Disparities62025
P01CA097132Sphingolipids in Cancer Biology and Therapy52025
P20GM113117Chemical Biology of Infectious Disease52025
P30CA023168Cancer Center Support Grant52025
T32CA009109Cancer Research Training Program: From Molecular Mechanisms to Therapeutic Strategies52025

1 to 10 of 1,909Source NIH's project files

See all 1,909 nih grants

Papers4,146

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826080PubTator, text miningPubMed
42782116PubTator, text miningPubMed
42696602PubTator, text miningPubMed
42612629PubTator, text miningPubMed
42480703PubTator, text miningPubMed
42469225PubTator, text miningPubMed
42407282PubTator, text miningPubMed
41967793PubTator, text miningPubMed
41924992PubTator, text miningPubMed
41914529PubTator, text miningPubMed

1 to 10 of 4,146

See all 4,146 papers

Sources 11

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNone stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GeneNone named. Public domain as US government information
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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