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Gene · 5500

PPP1CB: protein phosphatase 1 catalytic subunit beta

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PPP1CB: protein phosphatase 1 catalytic subunit beta. Genes, record 5500. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5500

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Gene

Symbol
PPP1CB
HGNC
Name
protein phosphatase 1 catalytic subunit beta
HGNC
NCBI Gene ID
5500
NCBI Gene
HGNC ID
HGNC:9282
HGNC
Ensembl
ENSG00000213639
NCBI Gene
Aliases
HEL-S-80p, MP, NSLH2, PP-1B, PP1B, PP1Cbeta, PP1Cdelta, PP1beta, PP1c, PPP1CD, PPP1beta
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P62140Serine/threonine-protein phosphatase PP1-beta catalytic subunit3270Ensembl, GeneID, HGNC

Source UniProt

Patents66

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459831P62140Espacenet
JP 2026004568 A2026-01-1459832P62140Espacenet
JP 2026004568 A2026-01-1459833P62140Espacenet
EP 4650780 A22025-11-193686P62140Espacenet
EP 4641201 A22025-10-293281P62140Espacenet
JP 2025517969 A2025-06-123281P62140Espacenet
JP 2025517970 A2025-06-123686P62140Espacenet
US 11446398 B22022-09-2068442P62140Espacenet
US 11446398 B22022-09-2068443P62140Espacenet
US 11446398 B22022-09-2068444P62140Espacenet

1 to 10 of 66

See all 66 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,061

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePPP1CB papersNewest fiscal year
P30CA008748Cancer Center Support Grant92025
P30AI117970District of Columbia Center for AIDS Research52025
P30CA016520Abramson Cancer Center Support Grant42025
P30CA016672Cancer Center Support Grant42025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control42025
P30CA036727Buffett Cancer Center Support Grant32025
P30CA046934University of Colorado Cancer Center Support Grant32025
P30CA068485Cancer Center Support Grant32025
R35GM127289Cyclin-dependent kinase control of cell-division and transcription cycles32025
U54MD007597Howard University Research Center for Minority Health and Health Disparities32025

1 to 10 of 1,061Source NIH's project files

See all 1,061 nih grants

Papers1,416

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Thoracic Aortic Disease in Genetic Syndromes Beyond Established Aortopathy Genes.medRxiv202642818859PubTator, text miningPubMed
S-palmitoylation stabilizes OGT and the OGT-PPP1CC complex.Acta Biochim Biophys Sin (Shanghai)202642784431PubTator, text miningPubMed
PPP1CB-Related Noonan Syndrome with Loose Anagen Hair: A Systematic Review.Genes (Basel)202642353762PubTator, text miningPubMed
Lipid Metabolic Rewiring During Continuous Prostate Cancer Progression Defines a Biologically Relevant Four-Gene Prognostic Signature.Biol Proced Online202642185987PubTator, text miningPubMed
Ultrasensitive non-enzymatic protein detection using proximity immunoassay with photonic resonator absorption microscopy.NPJ Biosens202642164720PubTator, text miningPubMed
A Patient With Novel PPP1CB -ALK Fusion Advanced NSCLC Achieved Long Survival From Alectinib: A Case Report.JTO Clin Res Rep202642158271PubTator, text miningPubMed
A rare RASopathy: Noonan syndrome-like disorder with loose anagen hair caused by a protein phosphatase 1 catalytic subunit beta pathogenic variant.Clin Dysmorphol202642059183PubTator, text miningPubMed
Clinical and Genetic Characterization of Noonan Syndrome in a Colombian Pediatric CohortJ Clin Res Pediatr Endocrinol202641988663PubTator, text miningPubMed
Alternative Polyadenylation Signatures Distinguish Maladaptive Right Ventricular Remodeling in Pulmonary Hypertension: Implications for RNA-Based Diagnostics and Therapeutics.Br J Biomed Sci202641799857PubTator, text miningPubMed
The CD97-PPM1G axis dampens antiviral immunity by dephosphorylating IRF7 in type I interferon pathway.PLoS Pathog202641774756PubTator, text miningPubMed

1 to 10 of 1,416

See all 1,416 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5500

GET https://conductscience.org/api/genes/v1/5500/patents?page=2