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Gene · 5518

PPP2R1A: protein phosphatase 2 scaffold subunit Aalpha

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PPP2R1A: protein phosphatase 2 scaffold subunit Aalpha. Genes, record 5518. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5518

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Gene

Symbol
PPP2R1A
HGNC
Name
protein phosphatase 2 scaffold subunit Aalpha
HGNC
NCBI Gene ID
5518
NCBI Gene
HGNC ID
HGNC:9302
HGNC
Ensembl
ENSG00000105568
NCBI Gene
Aliases
HJS2, MRD36, PP2A-Aalpha, PP2AA, PP2AAALPHA, PR65A
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P30153Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform58941Ensembl, GeneID, HGNC

Source UniProt

Patents42

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-195573P30153Espacenet
EP 4641201 A22025-10-295203P30153Espacenet
JP 2025517969 A2025-06-125203P30153Espacenet
JP 2025517970 A2025-06-125573P30153Espacenet
JP 2024123008 A2024-09-107882P30153Espacenet
JP 2023064789 A2023-05-1286P30153Espacenet
WO 2023074712 A2023-05-0432P30153Espacenet
US 11446398 B22022-09-2068695P30153Espacenet
JP 2022524081 A2022-04-27171666P30153Espacenet
US 11078247 B22021-08-038847P30153Espacenet

1 to 10 of 42

See all 42 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,381

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePPP2R1A papersNewest fiscal year
P30CA008748Cancer Center Support Grant402025
P30CA016672Cancer Center Support Grant182025
P30CA006973Regional Oncology Research Center102025
ZIAHG200338Molecular Analyses of Endometrial Cancer102025
R35GM119455Mechanisms of Phosphorylation Signaling by Phosphoprotein Phosphatases82025
UL1TR001863Yale Clinical and Translational Science Award82025
P30CA016359Cancer Center Support Grant62025
P50CA247749MSK SPORE in Genomic Instability in Breast Cancer52025
P20GM113132The Institute for Biomolecular Targeting42025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant42025

1 to 10 of 1,381Source NIH's project files

See all 1,381 nih grants

Papers1,733

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
E3 ligase RNF145 regulates airway smooth muscle cell proliferation via the PP2A-p70S6K signaling axis.J Biol Chem202642575436PubTator, text miningPubMed
Long-read, whole-genome sequencing and chemotherapy response of two patient-derived organoids from a TP53- and KRAS-mutant ovarian carcinoma.bioRxiv202642465424PubTator, text miningPubMed
SnRNA-seq and genome-wide CRISPR screening define the complete transcriptional trajectory and functional drivers of podocyte stress.Cell Mol Life Sci202642440147PubTator, text miningPubMed
The role of PPP2R1A variants in gynecologic malignancies: a paradigm shift in immuno-oncology.J Transl Med202642063097PubTator, text miningPubMed
Design and evaluation of a custom circulating tumour DNA assay to detect endometrial cancer recurrence.NPJ Precis Oncol202641872329PubTator, text miningPubMed
Phosphoethanolamine cytidylyltransferase 2 exerts an anti-tumor role in clear cell renal cell carcinoma by modulating the hippo/YAP1 signaling pathway in a PPP2R1A-dependent manner.Toxicol Appl Pharmacol202641802576PubTator, text miningPubMed
Transcriptional control of PPP2CB by YAP1 and TEAD1 mediates AMPK inhibition and mTORC1 activation in vascular smooth muscle cells.iScience202641797917PubTator, text miningPubMed
Succinylation: novel molecular mechanisms and prospects for targeted therapy in liver diseases.Front Mol Biosci202641788628PubTator, text miningPubMed
Comprehensive Genomic Profiling Across Diverse Solid Tumors: A Real-World Experience From India With FoundationOne®CDx Testing.Cureus202641717185PubTator, text miningPubMed
Molecular Landscape of Advanced Endometrial Cancer: Exploratory Analyses at Modena Cancer Center (MEMO).Int J Mol Sci202641596744PubTator, text miningPubMed

1 to 10 of 1,733

See all 1,733 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5518

GET https://conductscience.org/api/genes/v1/5518/patents?page=2