Gene · 5518
PPP2R1A: protein phosphatase 2 scaffold subunit Aalpha
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PPP2R1A: protein phosphatase 2 scaffold subunit Aalpha. Genes, record 5518. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5518
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P30153 | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform | 589 | 41 | Ensembl, GeneID, HGNC |
Source UniProt
Patents42
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 5573 | P30153 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 5203 | P30153 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 5203 | P30153 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 5573 | P30153 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 7882 | P30153 | Espacenet |
| JP 2023064789 A | 2023-05-12 | 86 | P30153 | Espacenet |
| WO 2023074712 A | 2023-05-04 | 32 | P30153 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 68695 | P30153 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 171666 | P30153 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 8847 | P30153 | Espacenet |
1 to 10 of 42
See all 42 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,381
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PPP2R1A papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 40 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 18 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 10 | 2025 |
| ZIAHG200338 | Molecular Analyses of Endometrial Cancer | 10 | 2025 |
| R35GM119455 | Mechanisms of Phosphorylation Signaling by Phosphoprotein Phosphatases | 8 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 8 | 2025 |
| P30CA016359 | Cancer Center Support Grant | 6 | 2025 |
| P50CA247749 | MSK SPORE in Genomic Instability in Breast Cancer | 5 | 2025 |
| P20GM113132 | The Institute for Biomolecular Targeting | 4 | 2025 |
| P30CA015083 | Mayo Clinic Comprehensive Cancer Center Support Grant | 4 | 2025 |
1 to 10 of 1,381Source NIH's project files
See all 1,381 nih grantsPapers1,733
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| E3 ligase RNF145 regulates airway smooth muscle cell proliferation via the PP2A-p70S6K signaling axis. | J Biol Chem | 2026 | 42575436 | PubTator, text mining | PubMed |
| Long-read, whole-genome sequencing and chemotherapy response of two patient-derived organoids from a TP53- and KRAS-mutant ovarian carcinoma. | bioRxiv | 2026 | 42465424 | PubTator, text mining | PubMed |
| SnRNA-seq and genome-wide CRISPR screening define the complete transcriptional trajectory and functional drivers of podocyte stress. | Cell Mol Life Sci | 2026 | 42440147 | PubTator, text mining | PubMed |
| The role of PPP2R1A variants in gynecologic malignancies: a paradigm shift in immuno-oncology. | J Transl Med | 2026 | 42063097 | PubTator, text mining | PubMed |
| Design and evaluation of a custom circulating tumour DNA assay to detect endometrial cancer recurrence. | NPJ Precis Oncol | 2026 | 41872329 | PubTator, text mining | PubMed |
| Phosphoethanolamine cytidylyltransferase 2 exerts an anti-tumor role in clear cell renal cell carcinoma by modulating the hippo/YAP1 signaling pathway in a PPP2R1A-dependent manner. | Toxicol Appl Pharmacol | 2026 | 41802576 | PubTator, text mining | PubMed |
| Transcriptional control of PPP2CB by YAP1 and TEAD1 mediates AMPK inhibition and mTORC1 activation in vascular smooth muscle cells. | iScience | 2026 | 41797917 | PubTator, text mining | PubMed |
| Succinylation: novel molecular mechanisms and prospects for targeted therapy in liver diseases. | Front Mol Biosci | 2026 | 41788628 | PubTator, text mining | PubMed |
| Comprehensive Genomic Profiling Across Diverse Solid Tumors: A Real-World Experience From India With FoundationOne®CDx Testing. | Cureus | 2026 | 41717185 | PubTator, text mining | PubMed |
| Molecular Landscape of Advanced Endometrial Cancer: Exploratory Analyses at Modena Cancer Center (MEMO). | Int J Mol Sci | 2026 | 41596744 | PubTator, text mining | PubMed |
1 to 10 of 1,733
See all 1,733 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5518
GET https://conductscience.org/api/genes/v1/5518/patents?page=2