Gene · 5530
PPP3CA: protein phosphatase 3 catalytic subunit alpha
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PPP3CA: protein phosphatase 3 catalytic subunit alpha. Genes, record 5530. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5530
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q08209 | Protein phosphatase 3 catalytic subunit alpha | 521 | 21 | Ensembl, GeneID, HGNC |
Source UniProt
Patents58
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 11196 | Q08209 | Espacenet |
| JP 2025122064 A | 2025-08-20 | 65 | Q08209 | Espacenet |
| JP 2025107358 A | 2025-07-17 | 65 | Q08209 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 11196 | Q08209 | Espacenet |
| EP 4491229 A2 | 2025-01-15 | 184 | Q08209 | Espacenet |
| WO 2024230934 A1 | 2024-11-14 | 309 | Q08209 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 7897 | Q08209 | Espacenet |
| US 11708396 B2 | 2023-07-25 | 1488 | Q08209 | Espacenet |
| JP 2023520205 A | 2023-05-16 | 65 | Q08209 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 68841 | Q08209 | Espacenet |
1 to 10 of 58
See all 58 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| VOCLOSPORIN | CHEMBL5314379 | Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform inhibitor | INHIBITOR |
Source ChEMBL
Trials20
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07225387 | VOCLOSPORIN | PHASE4 | ClinicalTrials.gov | |
| NCT07053891 | VOCLOSPORIN | ClinicalTrials.gov | ||
| NCT06406205 | VOCLOSPORIN | PHASE3 | ClinicalTrials.gov | |
| NCT05962788 | VOCLOSPORIN | PHASE3 | ClinicalTrials.gov | |
| NCT05337124 | VOCLOSPORIN | ClinicalTrials.gov | ||
| NCT05306873 | VOCLOSPORIN | PHASE2 | 2025-09-09 | ClinicalTrials.gov |
| NCT05288855 | VOCLOSPORIN | PHASE3 | ClinicalTrials.gov | |
| NCT04147650 | VOCLOSPORIN | PHASE2/PHASE3 | 2021-12-10 | ClinicalTrials.gov |
| NCT03598036 | VOCLOSPORIN | PHASE2 | 2021-09-16 | ClinicalTrials.gov |
| NCT03597464 | VOCLOSPORIN | PHASE3 | 2022-12-14 | ClinicalTrials.gov |
1 to 10 of 20
See all 20 trialsNIH grants956
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PPP3CA papers | Newest fiscal year |
|---|---|---|---|
| R01AI040127 | Signal transduction and gene induction in lymphocytes | 3 | 2025 |
| R35GM136243 | Elucidating calcineurin signaling mechanisms at membranes | 3 | 2025 |
| P30AI073961 | Miami Center for AIDS Research | 2 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 2 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 2 | 2025 |
| P30ES019776 | HERCULES: Exposome Research Center | 2 | 2025 |
| R01HL070562 | Actions of Estrogen on Uterine Artery Endothelium | 2 | 2025 |
| R35CA197568 | Lung Adenocarcinoma: From Genome Alterations to Therapeutic Discovery | 2 | 2025 |
| ZIAAI001222 | Characterization of the cellular and molecular bases of inborn errors of immunity | 2 | 2025 |
| D43TW009114 | Psychiatric research infrastructure for intervention and implementation in India – TEAMS | 1 | 2025 |
1 to 10 of 956Source NIH's project files
See all 956 nih grantsPapers1,159
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Analysis of Rare Coding Variation Identifies New Genetic Contributors to Schizophrenia. | bioRxiv | 2026 | 42818077 | PubTator, text mining | PubMed |
| CCN1-induced senescence and dysfunction of umbilical cord blood endothelial colony-forming cells in the pathogenesis of preeclampsia. | Front Endocrinol (Lausanne) | 2026 | 42729181 | PubTator, text mining | PubMed |
| Integrative network toxicology and single-cell analysis implicates a potential TGFBR1-centered fibroblast remodeling axis in Benzo[a]pyrene-related atrial fibrillation. | Environ Int | 2026 | 42364542 | PubTator, text mining | PubMed |
| Omics signature of new-onset mild cognitive impairment and dementia in a population-based study. | Sci Rep | 2026 | 42303781 | PubTator, text mining | PubMed |
| Identification and Regulation of Common Key Genes in COPD and AD. | Comb Chem High Throughput Screen | 2026 | 42227493 | PubTator, text mining | PubMed |
| Photosensitive infantile spasms in a preterm infant with 4q22.3-q24 deletion involving PPP3CA. | Epileptic Disord | 2026 | 42217193 | PubTator, text mining | PubMed |
| Decoding shared pathogenic networks of oxidative stress in neuropsychiatric disorders to prioritize multi-target therapeutics from natural products. | Cell Biol Toxicol | 2026 | 42166031 | PubTator, text mining | PubMed |
| Integrating Multi-omics, Mendelian Randomization, and Experimental Validation to Unveil the Role of Traditional Chinese Medicine in Postmenopausal Osteoporosis. | Curr Comput Aided Drug Des | 2026 | 42136208 | PubTator, text mining | PubMed |
| A microRNA expression signature in infant t(4;11) KMT2A::AFF1+ BCP-ALL uncovers novel therapeutic targets. | Hemasphere | 2026 | 42038742 | PubTator, text mining | PubMed |
| A Pseudokinase Catalyzes Nitrile Formation in the Biosynthesis of a Potent Marine Toxin. | Angew Chem Int Ed Engl | 2026 | 41979219 | PubTator, text mining | PubMed |
1 to 10 of 1,159
See all 1,159 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5530
GET https://conductscience.org/api/genes/v1/5530/patents?page=2