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Gene · 5530

PPP3CA: protein phosphatase 3 catalytic subunit alpha

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PPP3CA: protein phosphatase 3 catalytic subunit alpha. Genes, record 5530. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5530

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Gene

Symbol
PPP3CA
HGNC
Name
protein phosphatase 3 catalytic subunit alpha
HGNC
NCBI Gene ID
5530
NCBI Gene
HGNC ID
HGNC:9314
HGNC
Ensembl
ENSG00000138814
NCBI Gene
Aliases
ACCIID, CALN, CALNA, CALNA1, CNA1, DEE91, IECEE, IECEE1, PPP2B
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q08209Protein phosphatase 3 catalytic subunit alpha52121Ensembl, GeneID, HGNC

Source UniProt

Patents58

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1911196Q08209Espacenet
JP 2025122064 A2025-08-2065Q08209Espacenet
JP 2025107358 A2025-07-1765Q08209Espacenet
JP 2025517970 A2025-06-1211196Q08209Espacenet
EP 4491229 A22025-01-15184Q08209Espacenet
WO 2024230934 A12024-11-14309Q08209Espacenet
JP 2024123008 A2024-09-107897Q08209Espacenet
US 11708396 B22023-07-251488Q08209Espacenet
JP 2023520205 A2023-05-1665Q08209Espacenet
US 11446398 B22022-09-2068841Q08209Espacenet

1 to 10 of 58

See all 58 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
VOCLOSPORINCHEMBL5314379Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform inhibitorINHIBITOR

Source ChEMBL

Trials20

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07225387VOCLOSPORINPHASE4ClinicalTrials.gov
NCT07053891VOCLOSPORINClinicalTrials.gov
NCT06406205VOCLOSPORINPHASE3ClinicalTrials.gov
NCT05962788VOCLOSPORINPHASE3ClinicalTrials.gov
NCT05337124VOCLOSPORINClinicalTrials.gov
NCT05306873VOCLOSPORINPHASE22025-09-09ClinicalTrials.gov
NCT05288855VOCLOSPORINPHASE3ClinicalTrials.gov
NCT04147650VOCLOSPORINPHASE2/PHASE32021-12-10ClinicalTrials.gov
NCT03598036VOCLOSPORINPHASE22021-09-16ClinicalTrials.gov
NCT03597464VOCLOSPORINPHASE32022-12-14ClinicalTrials.gov

1 to 10 of 20

See all 20 trials

NIH grants956

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePPP3CA papersNewest fiscal year
R01AI040127Signal transduction and gene induction in lymphocytes32025
R35GM136243Elucidating calcineurin signaling mechanisms at membranes32025
P30AI073961Miami Center for AIDS Research22025
P30CA006973Regional Oncology Research Center22025
P30CA016672Cancer Center Support Grant22025
P30ES019776HERCULES: Exposome Research Center22025
R01HL070562Actions of Estrogen on Uterine Artery Endothelium22025
R35CA197568Lung Adenocarcinoma: From Genome Alterations to Therapeutic Discovery22025
ZIAAI001222Characterization of the cellular and molecular bases of inborn errors of immunity22025
D43TW009114Psychiatric research infrastructure for intervention and implementation in India – TEAMS12025

1 to 10 of 956Source NIH's project files

See all 956 nih grants

Papers1,159

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Analysis of Rare Coding Variation Identifies New Genetic Contributors to Schizophrenia.bioRxiv202642818077PubTator, text miningPubMed
CCN1-induced senescence and dysfunction of umbilical cord blood endothelial colony-forming cells in the pathogenesis of preeclampsia.Front Endocrinol (Lausanne)202642729181PubTator, text miningPubMed
Integrative network toxicology and single-cell analysis implicates a potential TGFBR1-centered fibroblast remodeling axis in Benzo[a]pyrene-related atrial fibrillation.Environ Int202642364542PubTator, text miningPubMed
Omics signature of new-onset mild cognitive impairment and dementia in a population-based study.Sci Rep202642303781PubTator, text miningPubMed
Identification and Regulation of Common Key Genes in COPD and AD.Comb Chem High Throughput Screen202642227493PubTator, text miningPubMed
Photosensitive infantile spasms in a preterm infant with 4q22.3-q24 deletion involving PPP3CA.Epileptic Disord202642217193PubTator, text miningPubMed
Decoding shared pathogenic networks of oxidative stress in neuropsychiatric disorders to prioritize multi-target therapeutics from natural products.Cell Biol Toxicol202642166031PubTator, text miningPubMed
Integrating Multi-omics, Mendelian Randomization, and Experimental Validation to Unveil the Role of Traditional Chinese Medicine in Postmenopausal Osteoporosis.Curr Comput Aided Drug Des202642136208PubTator, text miningPubMed
A microRNA expression signature in infant t(4;11) KMT2A::AFF1+ BCP-ALL uncovers novel therapeutic targets.Hemasphere202642038742PubTator, text miningPubMed
A Pseudokinase Catalyzes Nitrile Formation in the Biosynthesis of a Potent Marine Toxin.Angew Chem Int Ed Engl202641979219PubTator, text miningPubMed

1 to 10 of 1,159

See all 1,159 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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