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Gene · 5531

PPP4C: protein phosphatase 4 catalytic subunit

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PPP4C: protein phosphatase 4 catalytic subunit. Genes, record 5531. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5531

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Gene

Symbol
PPP4C
HGNC
Name
protein phosphatase 4 catalytic subunit
HGNC
NCBI Gene ID
5531
NCBI Gene
HGNC ID
HGNC:9319
HGNC
Ensembl
ENSG00000149923
NCBI Gene
Aliases
PP-X, PP4, PP4C, PPH3, PPP4, PPX
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P60510Serine/threonine-protein phosphatase 4 catalytic subunit3070Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459995P60510Espacenet
EP 4650780 A22025-11-193062P60510Espacenet
JP 2025517970 A2025-06-123062P60510Espacenet
EP 4464338 A22024-11-20183P60510Espacenet
US 11680268 B22023-06-20183P60510Espacenet
US 11446398 B22022-09-2068864P60510Espacenet
US 11446398 B22022-09-2068866P60510Espacenet
JP 2022524081 A2022-04-27171835P60510Espacenet
JP 2022524081 A2022-04-27171837P60510Espacenet
US 11078247 B22021-08-038865P60510Espacenet

1 to 10 of 31

See all 31 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,044

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePPP4C papersNewest fiscal year
R35GM119455Mechanisms of Phosphorylation Signaling by Phosphoprotein Phosphatases152025
P20GM113132The Institute for Biomolecular Targeting102025
P30CA023108Cancer Center Support Grant82025
P30CA008748Cancer Center Support Grant62025
P30CA016672Cancer Center Support Grant42025
R01GM094231COMPUTATIONAL TOOLS FOR MASS SPECTROMETRY-BASED INTERACTOME DATA32025
P01CA092584Structural Cell Biology of DNA Repair Machines22025
P30CA015704Cancer Center Support Grant22025
P30CA016087Cancer Center Support Grant22025
P30CA033572Cancer Center Support Grant22025

1 to 10 of 1,044Source NIH's project files

See all 1,044 nih grants

Papers1,401

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
PP4 deficiency drives airway epithelial senescence via the PERK-eIF2α-ATF4-p21 axis in severe asthma.Inflamm Res202642802286PubTator, text miningPubMed
An integrated single-cell and Mendelian randomization analysis of stromal features in Asherman's syndrome and endometrial cancer.Cancer Treat Res Commun202642727551PubTator, text miningPubMed
CDK2-mediated phosphorylation of TRF1 S11 facilitates DNA damage repair by remodeling telomeric chromatin.Cell Death Differ202642552398PubTator, text miningPubMed
The regulation of protein phosphatase 4 by FBXO42 is required for cancer cell survival.EMBO Rep202642448956PubTator, text miningPubMed
Holding the PP2A and PP4 protein phosphatases at bay: emerging roles of FBXO42 and CCDC6.EMBO Rep202642448955PubTator, text miningPubMed
Translating transcriptomics analysis into diagnostic workflows: clinical variant identification and interpretation in hypothesis-driven and hypothesis-free approaches.EBioMedicine202642208150PubTator, text miningPubMed
Stage-specific biomarkers in triple-negative breast cancer: Preliminary findings from bioinformatics approaches.Cancer Biomark202642206911PubTator, text miningPubMed
Advancing PCOS drug development: multi-omics discovery of key targets and repurposable compounds.Naunyn Schmiedebergs Arch Pharmacol202642171750PubTator, text miningPubMed
The characteristics and mechanism of phosphorus adsorption and release of extracellular polymeric substances in biofilms based on phosphorus recovery.Bioresour Technol202642128236PubTator, text miningPubMed
Antibiotic-driven mechanisms in endogenous partial denitrification (EPD): Nitrite accumulation, microbial adaptation, functional gene responses and resistance gene proliferation.J Hazard Mater202642096753PubTator, text miningPubMed

1 to 10 of 1,401

See all 1,401 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5531

GET https://conductscience.org/api/genes/v1/5531/patents?page=2