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Gene · 5538

PPT1: palmitoyl-protein thioesterase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PPT1: palmitoyl-protein thioesterase 1. Genes, record 5538. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5538

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Gene

Symbol
PPT1
HGNC
Name
palmitoyl-protein thioesterase 1
HGNC
NCBI Gene ID
5538
NCBI Gene
HGNC ID
HGNC:9325
HGNC
Ensembl
ENSG00000131238
NCBI Gene
Aliases
CLN1, INCL, PPT
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P50897Palmitoyl-protein thioesterase 13061Ensembl, GeneID, HGNC

Source UniProt

Patents124

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026515744 A2026-05-1929P50897Espacenet
JP 2026067851 A2026-04-21297P50897Espacenet
JP 2026511472 A2026-04-1429P50897Espacenet
EP 4704920 A12026-03-11136P50897Espacenet
JP 2026021331 A2026-02-104P50897Espacenet
JP 2026021331 A2026-02-1020P50897Espacenet
EP 4683659 A22026-01-2829P50897Espacenet
JP 2026004568 A2026-01-1456943P50897Espacenet
JP 2026004568 A2026-01-1456945P50897Espacenet
EP 4667578 A22025-12-24273P50897Espacenet

1 to 10 of 124

See all 124 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,002

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePPT1 papersNewest fiscal year
ZIAHD000910Childhood Neurodegenerative Lysosomal Storage Disorders202025
P30CA016520Abramson Cancer Center Support Grant102025
R35GM119840Chemical biology approaches to probe signaling by protein lipidation72025
P30CA010815Consolidated Basic Cancer Research Program62025
P30AR072571Boston University CCCR52025
UL1TR002345Washington University Institute of Clinical and Translational Sciences52025
P30CA091842Cancer Center Support Grant42025
P30DK020579Diabetes Research Center42025
P50CA261608SPORE in Skin Cancer42025
R01CA266404Resistance mechanisms to autophagy-modulating therapies42025

1 to 10 of 1,002Source NIH's project files

See all 1,002 nih grants

Papers1,803

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Intracerebroventricular repeat dose CPI-601 recombinant human palmitoyl-protein thioesterase-1 in cynomolgus monkey: safety, pharmacokinetics, and dose selection.Mol Genet Metab202642641355PubTator, text miningPubMed
Photocatalytic Golgi Proteomics Reveals Palmitoylation-Regulated Golgiphagy.J Am Chem Soc202642619132PubTator, text miningPubMed
Palmitoylation-related gene signature for immune subtyping, prognostic stratification, and immunotherapy guidance in hepatocellular carcinoma.Transl Cancer Res202642591901PubTator, text miningPubMed
[Prognostic value of palmitoyl-protein thioesterase-1 in gastric cancer and its regulatory role in tumor cell lipid metabolism].Nan Fang Yi Ke Da Xue Xue Bao202642576500PubTator, text miningPubMed
Phenotypic and Genetic Characterization of 64 Egyptian Children With Neuronal Ceroid Lipofuscinosis.Pediatr Neurol202642551284PubTator, text miningPubMed
Palmitoylation of TK1 exacerbates osteoarthritis by promoting JNK-mediated metabolic reprogramming.Proc Natl Acad Sci U S A202642546205PubTator, text miningPubMed
ZDHHC-Mediated Protein S-Palmitoylation in Cancer: Epigenetic Interfaces, Structural Logic and Therapeutic Targeting.Int J Med Sci202642524518PubTator, text miningPubMed
Erratum to "Dual Regulation of Sprouty 4 Palmitoylation by ZDHHC7 and Palmitoyl-Protein Thioesterase 1: A Potential Therapeutic Strategy for Cisplatin-Resistant Osteosarcoma".Research (Wash D C)202642517161PubTator, text miningPubMed
The causal relationship between the palmitoylation gene ZDHHC13 and ulcerative colitis: A Mendelian randomization study implicating CD62L-monocyte AC.Medicine (Baltimore)202642410861PubTator, text miningPubMed
High-definition transcranial direct current stimulation enhances exercise-induced hypoalgesia in patients with chronic low back pain.iScience202642403639PubTator, text miningPubMed

1 to 10 of 1,803

See all 1,803 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5538

GET https://conductscience.org/api/genes/v1/5538/patents?page=2