Gene · 5538
PPT1: palmitoyl-protein thioesterase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PPT1: palmitoyl-protein thioesterase 1. Genes, record 5538. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5538
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P50897 | Palmitoyl-protein thioesterase 1 | 306 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents124
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026515744 A | 2026-05-19 | 29 | P50897 | Espacenet |
| JP 2026067851 A | 2026-04-21 | 297 | P50897 | Espacenet |
| JP 2026511472 A | 2026-04-14 | 29 | P50897 | Espacenet |
| EP 4704920 A1 | 2026-03-11 | 136 | P50897 | Espacenet |
| JP 2026021331 A | 2026-02-10 | 4 | P50897 | Espacenet |
| JP 2026021331 A | 2026-02-10 | 20 | P50897 | Espacenet |
| EP 4683659 A2 | 2026-01-28 | 29 | P50897 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 56943 | P50897 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 56945 | P50897 | Espacenet |
| EP 4667578 A2 | 2025-12-24 | 273 | P50897 | Espacenet |
1 to 10 of 124
See all 124 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,002
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PPT1 papers | Newest fiscal year |
|---|---|---|---|
| ZIAHD000910 | Childhood Neurodegenerative Lysosomal Storage Disorders | 20 | 2025 |
| P30CA016520 | Abramson Cancer Center Support Grant | 10 | 2025 |
| R35GM119840 | Chemical biology approaches to probe signaling by protein lipidation | 7 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 6 | 2025 |
| P30AR072571 | Boston University CCCR | 5 | 2025 |
| UL1TR002345 | Washington University Institute of Clinical and Translational Sciences | 5 | 2025 |
| P30CA091842 | Cancer Center Support Grant | 4 | 2025 |
| P30DK020579 | Diabetes Research Center | 4 | 2025 |
| P50CA261608 | SPORE in Skin Cancer | 4 | 2025 |
| R01CA266404 | Resistance mechanisms to autophagy-modulating therapies | 4 | 2025 |
1 to 10 of 1,002Source NIH's project files
See all 1,002 nih grantsPapers1,803
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Intracerebroventricular repeat dose CPI-601 recombinant human palmitoyl-protein thioesterase-1 in cynomolgus monkey: safety, pharmacokinetics, and dose selection. | Mol Genet Metab | 2026 | 42641355 | PubTator, text mining | PubMed |
| Photocatalytic Golgi Proteomics Reveals Palmitoylation-Regulated Golgiphagy. | J Am Chem Soc | 2026 | 42619132 | PubTator, text mining | PubMed |
| Palmitoylation-related gene signature for immune subtyping, prognostic stratification, and immunotherapy guidance in hepatocellular carcinoma. | Transl Cancer Res | 2026 | 42591901 | PubTator, text mining | PubMed |
| [Prognostic value of palmitoyl-protein thioesterase-1 in gastric cancer and its regulatory role in tumor cell lipid metabolism]. | Nan Fang Yi Ke Da Xue Xue Bao | 2026 | 42576500 | PubTator, text mining | PubMed |
| Phenotypic and Genetic Characterization of 64 Egyptian Children With Neuronal Ceroid Lipofuscinosis. | Pediatr Neurol | 2026 | 42551284 | PubTator, text mining | PubMed |
| Palmitoylation of TK1 exacerbates osteoarthritis by promoting JNK-mediated metabolic reprogramming. | Proc Natl Acad Sci U S A | 2026 | 42546205 | PubTator, text mining | PubMed |
| ZDHHC-Mediated Protein S-Palmitoylation in Cancer: Epigenetic Interfaces, Structural Logic and Therapeutic Targeting. | Int J Med Sci | 2026 | 42524518 | PubTator, text mining | PubMed |
| Erratum to "Dual Regulation of Sprouty 4 Palmitoylation by ZDHHC7 and Palmitoyl-Protein Thioesterase 1: A Potential Therapeutic Strategy for Cisplatin-Resistant Osteosarcoma". | Research (Wash D C) | 2026 | 42517161 | PubTator, text mining | PubMed |
| The causal relationship between the palmitoylation gene ZDHHC13 and ulcerative colitis: A Mendelian randomization study implicating CD62L-monocyte AC. | Medicine (Baltimore) | 2026 | 42410861 | PubTator, text mining | PubMed |
| High-definition transcranial direct current stimulation enhances exercise-induced hypoalgesia in patients with chronic low back pain. | iScience | 2026 | 42403639 | PubTator, text mining | PubMed |
1 to 10 of 1,803
See all 1,803 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5538
GET https://conductscience.org/api/genes/v1/5538/patents?page=2