ConductScience.org, home

Gene · 554

AVPR2: arginine vasopressin receptor 2

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. AVPR2: arginine vasopressin receptor 2. Genes, record 554. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/554

On this page

Gene

Symbol
AVPR2
HGNC
Name
arginine vasopressin receptor 2
HGNC
NCBI Gene ID
554
NCBI Gene
HGNC ID
HGNC:897
HGNC
Ensembl
ENSG00000126895
NCBI Gene
Aliases
ADHR, DI1, DIR, DIR3, NDI, NDI1, V2R
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P30518Vasopressin V2 receptor37143Ensembl, GeneID, HGNC

Source UniProt

Patents53

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026062654 A2026-04-1058P30518Espacenet
JP 2026004568 A2026-01-1437811P30518Espacenet
JP 2026004568 A2026-01-1437812P30518Espacenet
WO 2025196440 A12025-09-252P30518Espacenet
JP 2025529142 A2025-09-04551P30518Espacenet
JP 2025126890 A2025-08-297P30518Espacenet
US 12371689 B22025-07-29551P30518Espacenet
JP 2025062604 A2025-04-146184P30518Espacenet
JP 2025062604 A2025-04-146185P30518Espacenet
JP 2025024198 A2025-02-199294P30518Espacenet

1 to 10 of 53

See all 53 patents

Drugs14

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ARGIPRESSIN TANNATECHEMBL2108986Vasopressin receptor agonistAGONISTChEMBL
CONIVAPTANCHEMBL1755Vasopressin V2 receptor antagonistANTAGONISTChEMBL
CONIVAPTAN HYDROCHLORIDECHEMBL1201108Vasopressin V2 receptor antagonistANTAGONISTChEMBL
DESMOPRESSINCHEMBL1429Vasopressin receptor agonistAGONISTChEMBL
DESMOPRESSIN ACETATECHEMBL1200556Vasopressin receptor agonistAGONISTChEMBL
LIXIVAPTANCHEMBL49429Vasopressin V2 receptor antagonistANTAGONISTChEMBL
LYPRESSINCHEMBL1200690Vasopressin receptor agonistAGONISTChEMBL
MOZAVAPTANCHEMBL420762Vasopressin V2 receptor antagonistANTAGONISTChEMBL
PECAVAPTANCHEMBL4594444Vasopressin V2 receptor antagonistANTAGONISTChEMBL
SATAVAPTANCHEMBL2107777Vasopressin V2 receptor antagonistANTAGONISTChEMBL

1 to 10 of 14

See all 14 drugs

Trials246

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,257

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleAVPR2 papersNewest fiscal year
R01HL016037Molecular Regulation of Cardiovascular 7 TM Receptors232025
ZIAHL001285Solute And Water Transport In Renal Epithelia142025
ZIAHL006129Computational Tools for Proteomics142025
R01DA012864Mechanisms and Cellular Function of Opioid Receptor Endocytosis102025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital72025
R01EY011500Structure-function studies of visual arrestin62025
R01HL122010Decrypting Variants of Uncertain Significance in Long-QT Syndrome62025
P51OD011132Emory National Primate Research Center52025
R01GM122798Biasing CXCR3 Signaling to Modulate the Inflammatory Response52025
R01MH054137Structure and Function of Dopamine Receptors52025

1 to 10 of 1,257Source NIH's project files

See all 1,257 nih grants

Papers2,697

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Disappearance of Posterior Pituitary Hyperintensity in Arginine Vasopressin Resistance: A Case Report.Turk Arch Pediatr202642826241PubTator, text miningPubMed
Functional characterization of genetic variants associated with rare inherited renal disorders in the Sri Lankan population.Mol Genet Genomics202642814169PubTator, text miningPubMed
Methylation Mesa define functional regulatory elements for targeted gene activation.Nat Commun202642786170PubTator, text miningPubMed
Impact of fluconazole in vasopressin 2 receptor-related congenital arginine vasopressin resistance.Kidney Int202642785711PubTator, text miningPubMed
Large-scale organoid-derived cyst cultures as a drug discovery platform for polycystic kidney disease.Kidney Int202642772449PubTator, text miningPubMed
Tolvaptan in heart failure: Contemporary evidence and a framework for precision decongestion.Heart Fail Rev202642714631PubTator, text miningPubMed
Nephrogenic Syndrome of Inappropriate Antidiuresis: Case Report and Genetic Perspectives.Nephrology (Carlton)202642685775PubTator, text miningPubMed
Universal pipeline for high-resolution GPCR structure determination.Nat Struct Mol Biol202642665663PubTator, text miningPubMed
SGLT2 inhibitors in autosomal dominant polycystic kidney disease: rationale, evidence gaps, and ongoing clinical trials.Int Urol Nephrol202642584781PubTator, text miningPubMed
X-Linked Nephrogenic Diabetes Insipidus Associated with the AVPR2 c.964C>T (p.Pro322Ser) Variant: A Family Case Series.J Clin Med202642513428PubTator, text miningPubMed

1 to 10 of 2,697

See all 2,697 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/554

GET https://conductscience.org/api/genes/v1/554/patents?page=2