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Gene · 5550

PREP: prolyl endopeptidase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PREP: prolyl endopeptidase. Genes, record 5550. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5550

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Gene

Symbol
PREP
HGNC
Name
prolyl endopeptidase
HGNC
NCBI Gene ID
5550
NCBI Gene
HGNC ID
HGNC:9358
HGNC
Ensembl
ENSG00000085377
NCBI Gene
Aliases
PE, PEP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P48147Prolyl endopeptidase71017Ensembl, GeneID, HGNC

Source UniProt

Patents29

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026062901 A2026-04-103P48147Espacenet
JP 2026035703 A2026-03-043P48147Espacenet
JP 2026004568 A2026-01-1459317P48147Espacenet
EP 4650780 A22025-11-1919787P48147Espacenet
JP 2025517970 A2025-06-1219787P48147Espacenet
JP 2025517104 A2025-06-031P48147Espacenet
JP 2025038131 A2025-03-183P48147Espacenet
EP 4517326 A22025-03-053P48147Espacenet
JP 2024503635 A2024-01-263P48147Espacenet
JP 2024503637 A2024-01-263P48147Espacenet

1 to 10 of 29

See all 29 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,282

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePREP papersNewest fiscal year
P30CA008748Cancer Center Support Grant82025
K24AG054415Mentoring Researchers in Advance Care Planning for Older Adults at Risk for Alzheimer’s Disease and Related Dementias and their Caregivers72025
P30CA013148Comprehensive Cancer Center Support Grant62025
R01DK063158Role of Transglutaminase 2 in Celiac Sprue62025
P30AG044281Improving the Telehealth Delivery of Care for Older Veterans with Cancer and Cognitive Impairment52025
R01NS038183Molecular Analysis of Hindbrain Development42025
T32HL007457Mechanisms of Hypertension and Cardiovascular Diseases42025
UL1TR001998Kentucky Center for Clinical and Translational Science42025
UL1TR002014Penn State Clinical and Translational Science Institute42025
P30AI045008Penn Center for AIDS Research32025

1 to 10 of 1,282Source NIH's project files

See all 1,282 nih grants

Papers2,494

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Patients With Pancreatitis-Related Gene Variants Showed Higher Incidence of Hyperpancreatic Enzymemia After Endoscopic Retrograde Cholangiopancreatography.DEN Open202742058267PubTator, text miningPubMed
Structure-based optimization, in vitro profiling, and ADMET prediction of Celastrol derivatives as potent prolyl endopeptidase inhibitors.Bioorg Chem202642673716PubTator, text miningPubMed
FAP-Inhibitor Homodimers with Engineered Linker-Spacer Units: Toward Optimized Radiopharmaceuticals.ACS Omega202642662658PubTator, text miningPubMed
Seed-Guided De Novo Design Expands the Structural Diversity of Antitoxin Protein Binders.bioRxiv202642620311PubTator, text miningPubMed
Bridging linguistic reasoning and biophysical reality toward peptide engineering via instruction-tuned language modeling.Bioinformatics202642608825PubTator, text miningPubMed
Perioperative pancreatic ductal adenocarcinoma care in 2025: who needs neoadjuvant?-who needs radiation?Gland Surg202642591952PubTator, text miningPubMed
Novel aspects of the renin-angiotensin-aldosterone system in septic shock.Curr Opin Physiol202642534273PubTator, text miningPubMed
A new series of FAP inhibitors for cancer imaging based on 8-substituted (4-quinolinoyl)-glycyl-2-cyanopyrrolidine.Nucl Med Biol202642526425PubTator, text miningPubMed
Identification of biallelic loss-of-function PREP variants in three individuals with syndromic intellectual disability.J Med Genet202642362369PubTator, text miningPubMed
Mass spectrometry-based proteomic profiling of human tauopathy brains suggests mitochondria-associated alterations.Front Mol Neurosci202642254865PubTator, text miningPubMed

1 to 10 of 2,494

See all 2,494 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5550

GET https://conductscience.org/api/genes/v1/5550/patents?page=2