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PRF1: perforin 1

1 protein, 74 patents, 0 drugs, 0 trials, 3,547 NIH grants and 5,856 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPRF1HGNC
Nameperforin 1HGNC
NCBI Gene ID5551NCBI Gene
HGNC IDHGNC:9360HGNC
EnsemblENSG00000180644NCBI Gene
AliasesHPLH2, P1, PFPNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P14222Perforin-15550Ensembl, GeneID, HGNCUniProt

Patents 74

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026505362 A2026-02-1359P14222Espacenet
JP 2026502616 A2026-01-238P14222Espacenet
JP 2026004568 A2026-01-1457334P14222Espacenet
JP 2026004568 A2026-01-1457335P14222Espacenet
JP 2026004568 A2026-01-1457336P14222Espacenet
EP 4661884 A22025-12-1759P14222Espacenet
EP 4653467 A12025-11-268P14222Espacenet
EP 4650780 A22025-11-199271P14222Espacenet
JP 2025147176 A2025-10-0610757P14222Espacenet
JP 2025147176 A2025-10-0610758P14222Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 3547

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant602,025NIH's project files
P30CA016672Cancer Center Support Grant392,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant252,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award222,025NIH's project files
P30DK120515San Diego Digestive Diseases Research Center192,025NIH's project files
P30CA016520Abramson Cancer Center Support Grant132,025NIH's project files
P50AA011999Southern California Research Center for ALPD and Cirrhosis132,025NIH's project files
P50CA101942DF/HCC Kidney Cancer SPORE (supplement)132,025NIH's project files
R01AA024726The Role of the Intestinal Mycobiome in Alcoholic Liver Disease132,025NIH's project files
U19AI057229Understanding Influenza and SARS-CoV-2 vaccine responses, in vivo and in vitro132,025NIH's project files

Papers 5856

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42812170PubTator, text miningPubMed
42800027PubTator, text miningPubMed
42777131PubTator, text miningPubMed
42757049PubTator, text miningPubMed
42754263PubTator, text miningPubMed
42709802PubTator, text miningPubMed
42706545PubTator, text miningPubMed
42688879PubTator, text miningPubMed
42650137PubTator, text miningPubMed
42614945PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license