Gene · 55512
SMPD3: sphingomyelin phosphodiesterase 3
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SMPD3: sphingomyelin phosphodiesterase 3. Genes, record 55512. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/55512
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9NY59 | Sphingomyelin phosphodiesterase 3 | 655 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents24
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4641202 A2 | 2025-10-29 | 16 | Q9NY59 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 4383 | Q9NY59 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 4383 | Q9NY59 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 16 | Q9NY59 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 83406 | Q9NY59 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 4482 | Q9NY59 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 186377 | Q9NY59 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 10707 | Q9NY59 | Espacenet |
| US 11078277 B2 | 2021-08-03 | 1 | Q9NY59 | Espacenet |
| US 10544466 B2 | 2020-01-28 | 11 | Q9NY59 | Espacenet |
1 to 10 of 24
See all 24 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants977
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SMPD3 papers | Newest fiscal year |
|---|---|---|---|
| P01CA097132 | Sphingolipids in Cancer Biology and Therapy | 25 | 2025 |
| P30MH075673 | JHU Center for the Advancement of HIV Neurotherapeutics (JHU CAHN) | 18 | 2025 |
| P30CA138313 | Medical University of South Carolina - Cancer Center Support Grant | 9 | 2025 |
| R35GM118128 | Neutral Sphingomyelinases and Bioactive Ceramides | 9 | 2025 |
| ZIABC005562 | Xenobiotic receptors | 8 | 2025 |
| R01CA126792 | Autophagy and Pro-metastatic Differentiation | 5 | 2025 |
| R01CA218678 | Ceramide Activated Protein Phosphatases | 5 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| R01AA011431 | FASD Inhibition of ASPH-Notch Mediates Adolescent Cerebral White Matter Pathology-Potential Utility of Non-invasive Extracellular Vesicle Assays | 4 | 2025 |
1 to 10 of 977Source NIH's project files
See all 977 nih grantsPapers1,535
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Function of HIF-1α in Regulating Sphingolipid Metabolism and Alleviating Oxidative Stress Damage in Callosobruchus chinensis Under Hypoxia. | Insects | 2026 | 42783271 | PubTator, text mining | PubMed |
| Endometriosis pain: genes linked to inflammation distinguish symptomatic from asymptomatic disease. | Mol Hum Reprod | 2026 | 42720599 | PubTator, text mining | PubMed |
| From physical impact to biological information flow: shock wave regulation of extracellular vesicles mediated tissue repair. | Front Cell Dev Biol | 2026 | 42682972 | PubTator, text mining | PubMed |
| Host determinants of exo-rAAV production revealed by extended gene expression analysis in HEK293 cells. | Mol Ther Adv | 2026 | 42662304 | PubTator, text mining | PubMed |
| Ligand‑Based Virtual Screening Discovery of Thienopyrimidinone Derivatives as Allosteric nSMase2 Modulators and Antivirals Against West Nile Virus. | ChemMedChem | 2026 | 42618991 | PubTator, text mining | PubMed |
| Development of a FRET-Based Assay for Human Neutral Sphingomyelinase 2. | Biochemistry | 2026 | 42610745 | PubTator, text mining | PubMed |
| Extracellular Vesicles in Cardiovascular Disease: Intercellular Signaling, Liquid Biopsy Biomarkers, and Therapeutic Translation. | Circ Res | 2026 | 42594169 | PubTator, text mining | PubMed |
| Sirtuin 1 Is Required for Optimal Mammarenavirus Multiplication. | bioRxiv | 2026 | 42539047 | PubTator, text mining | PubMed |
| SMPD3 suppresses oligodendroglioma growth via dual autocrine-paracrine roles. | Commun Biol | 2026 | 42365201 | PubTator, text mining | PubMed |
| Extracellular vesicle cargo dynamics in the bone marrow microenvironment: from hematopoietic homeostasis to malignant transformation. | Extracell Vesicle | 2026 | 42344609 | PubTator, text mining | PubMed |
1 to 10 of 1,535
See all 1,535 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/55512
GET https://conductscience.org/api/genes/v1/55512/patents?page=2