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Gene · 55512

SMPD3: sphingomyelin phosphodiesterase 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SMPD3: sphingomyelin phosphodiesterase 3. Genes, record 55512. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/55512

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Gene

Symbol
SMPD3
HGNC
Name
sphingomyelin phosphodiesterase 3
HGNC
NCBI Gene ID
55512
NCBI Gene
HGNC ID
HGNC:14240
HGNC
Ensembl
ENSG00000103056
NCBI Gene
Aliases
NSMASE2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NY59Sphingomyelin phosphodiesterase 36551Ensembl, GeneID, HGNC

Source UniProt

Patents24

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641202 A22025-10-2916Q9NY59Espacenet
JP 2025529142 A2025-09-044383Q9NY59Espacenet
US 12371689 B22025-07-294383Q9NY59Espacenet
KR 1020250017231 A2025-02-0416Q9NY59Espacenet
US 11446398 B22022-09-2083406Q9NY59Espacenet
US 11400116 B22022-08-024482Q9NY59Espacenet
JP 2022524081 A2022-04-27186377Q9NY59Espacenet
US 11078247 B22021-08-0310707Q9NY59Espacenet
US 11078277 B22021-08-031Q9NY59Espacenet
US 10544466 B22020-01-2811Q9NY59Espacenet

1 to 10 of 24

See all 24 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants977

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSMPD3 papersNewest fiscal year
P01CA097132Sphingolipids in Cancer Biology and Therapy252025
P30MH075673JHU Center for the Advancement of HIV Neurotherapeutics (JHU CAHN)182025
P30CA138313Medical University of South Carolina - Cancer Center Support Grant92025
R35GM118128Neutral Sphingomyelinases and Bioactive Ceramides92025
ZIABC005562Xenobiotic receptors82025
R01CA126792Autophagy and Pro-metastatic Differentiation52025
R01CA218678Ceramide Activated Protein Phosphatases52025
P30CA008748Cancer Center Support Grant42025
P30CA016672Cancer Center Support Grant42025
R01AA011431FASD Inhibition of ASPH-Notch Mediates Adolescent Cerebral White Matter Pathology-Potential Utility of Non-invasive Extracellular Vesicle Assays42025

1 to 10 of 977Source NIH's project files

See all 977 nih grants

Papers1,535

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Function of HIF-1α in Regulating Sphingolipid Metabolism and Alleviating Oxidative Stress Damage in Callosobruchus chinensis Under Hypoxia.Insects202642783271PubTator, text miningPubMed
Endometriosis pain: genes linked to inflammation distinguish symptomatic from asymptomatic disease.Mol Hum Reprod202642720599PubTator, text miningPubMed
From physical impact to biological information flow: shock wave regulation of extracellular vesicles mediated tissue repair.Front Cell Dev Biol202642682972PubTator, text miningPubMed
Host determinants of exo-rAAV production revealed by extended gene expression analysis in HEK293 cells.Mol Ther Adv202642662304PubTator, text miningPubMed
Ligand‑Based Virtual Screening Discovery of Thienopyrimidinone Derivatives as Allosteric nSMase2 Modulators and Antivirals Against West Nile Virus.ChemMedChem202642618991PubTator, text miningPubMed
Development of a FRET-Based Assay for Human Neutral Sphingomyelinase 2.Biochemistry202642610745PubTator, text miningPubMed
Extracellular Vesicles in Cardiovascular Disease: Intercellular Signaling, Liquid Biopsy Biomarkers, and Therapeutic Translation.Circ Res202642594169PubTator, text miningPubMed
Sirtuin 1 Is Required for Optimal Mammarenavirus Multiplication.bioRxiv202642539047PubTator, text miningPubMed
SMPD3 suppresses oligodendroglioma growth via dual autocrine-paracrine roles.Commun Biol202642365201PubTator, text miningPubMed
Extracellular vesicle cargo dynamics in the bone marrow microenvironment: from hematopoietic homeostasis to malignant transformation.Extracell Vesicle202642344609PubTator, text miningPubMed

1 to 10 of 1,535

See all 1,535 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/55512

GET https://conductscience.org/api/genes/v1/55512/patents?page=2