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Gene · 55553

SOX6: SRY-box transcription factor 6

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SOX6: SRY-box transcription factor 6. Genes, record 55553. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/55553

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Gene

Symbol
SOX6
HGNC
Name
SRY-box transcription factor 6
HGNC
NCBI Gene ID
55553
NCBI Gene
HGNC ID
HGNC:16421
HGNC
Ensembl
ENSG00000110693
NCBI Gene
Aliases
HSSOX6, SOXD, TOLCAS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P35712Transcription factor SOX-68280Ensembl, GeneID, HGNC

Source UniProt

Patents23

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1465436P35712Espacenet
JP 2026004568 A2026-01-1465440P35712Espacenet
EP 4641201 A22025-10-2918670P35712Espacenet
JP 2025147176 A2025-10-0615665P35712Espacenet
JP 2025517969 A2025-06-1218670P35712Espacenet
JP 2025032204 A2025-03-1136308P35712Espacenet
JP 2025028160 A2025-02-2815665P35712Espacenet
KR 1020250010750 A2025-01-2115665P35712Espacenet
EP 4461818 A22024-11-1336308P35712Espacenet
JP 2024109657 A2024-08-1415504P35712Espacenet

1 to 10 of 23

See all 23 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,650

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSOX6 papersNewest fiscal year
R01AR041398Novel Molecular Biomarkers of Bone Microarchitecture102025
P30CA008748Cancer Center Support Grant62025
R01HG003988Functionally Assessing Transcriptional Enhancers In Vivo62025
U19AG055373Trans-omics Integration of Multi-omics Studies for Osteoporosis62025
P20GM109036Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases52025
P30CA043703Case Comprehensive Cancer Center Support Grant52025
P30DK063491Diabetes Research Center (DRC)52025
P01HD084387Developmental Mechanisms of Human Idiopathic Scoliosis42025
UL1TR001863Yale Clinical and Translational Science Award42025
P01AG036675Kynurenine accumulation drives loss of muscle and bone function with aging32025

1 to 10 of 1,650Source NIH's project files

See all 1,650 nih grants

Papers2,174

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
CRISPR activation reveals SOX5/6/9 as key transcriptional regulators directing iPSC-derived cells toward a notochordal lineage.Stem Cell Reports202642660118PubTator, text miningPubMed
Integrated analysis of MYH6, MYH7, and MYH7B expression and their associated microRNAs in human end-stage heart failure.Front Cardiovasc Med202642630156PubTator, text miningPubMed
Proteomic dynamics in endochondral ossification: insights from antler tip analysis.PeerJ202642534826PubTator, text miningPubMed
Epigenetic Patterns in Musculoskeletal Disease: Methylation of DKK1, RHOJ, and SOX6 Genes in Osteoarthritis and Osteoporosis.Curr Issues Mol Biol202642510885PubTator, text miningPubMed
Shared genetic architecture of Parkinson's disease and cutaneous melanoma: Heterogeneous pleiotropy and Colocalization at the SOX6 locus.Prog Neuropsychopharmacol Biol Psychiatry202642335983PubTator, text miningPubMed
Engineering functional ventral midbrain dopaminergic neurons in human organoids through WNT modulation and bioreactor culture.Mol Psychiatry202642310192PubTator, text miningPubMed
Integrated transcriptomic and functional analysis reveals tissue-specific molecular pathology in adolescent idiopathic scoliosis.HGG Adv202642244182PubTator, text miningPubMed
Ocular Manifestations of Infectious Salmon Anaemia Virus Infection in Atlantic Salmon (Salmo salar).J Fish Dis202642226351PubTator, text miningPubMed
The Transcription Factor SOX6 Regulates Autophagy Levels Through LAMP5 to Inhibit the Development of Pituitary Adenomas.Appl Biochem Biotechnol202642012747PubTator, text miningPubMed
LncRNA PSMB8-AS1 contributes to post-infarction heart failure by aggravating myocardial injury and inflammation.Arch Biochem Biophys202641997398PubTator, text miningPubMed

1 to 10 of 2,174

See all 2,174 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/55553

GET https://conductscience.org/api/genes/v1/55553/patents?page=2